Ten Years of Tau-Targeted Immunotherapy: The Path Walked and the Roads Ahead
Frontiers in Neuroscience, 2018 Neurofibrillary pathology comprised of pathological tau protein is closely tied to a range of neurodegenerative disorders, the most common of which is Alzheimer’s disease.
Petr Novak +7 more
doaj +1 more source
The Tumor Suppressor HHEX Inhibits Axon Growth when Prematurely Expressed in Developing Central Nervous System Neurons [PDF]
, 2015 Neurons in the embryonic and peripheral nervoussystem respond to injury by activating transcriptional programs supportive of axon growth, ultimately resulting in functional recovery.
Blackmore, Murray G. +9 more
core +2 more sources
Frontiers in Aging Neuroscience, 2019 Alzheimer’s disease (AD), the most common tauopathy, is an age-dependent, progressive neurodegenerative disease. Epidemiological studies implicate the role of genetic background in the onset and progression of AD.
Tomas Smolek +11 more
doaj +1 more source
Intersection of pathological tau and microglia at the synapse
Acta Neuropathologica Communications, 2019 Tauopathies are a heterogenous class of diseases characterized by cellular accumulation of aggregated tau and include diseases such as Alzheimer’s disease (AD), progressive supranuclear palsy and chronic traumatic encephalopathy.
Thomas Vogels +2 more
doaj +1 more source
A sulfated carbohydrate epitope inhibits axon regeneration after injury [PDF]
, 2012 Chondroitin sulfate proteoglycans (CSPGs) represent a major barrier to regenerating axons in the central nervous system (CNS), but the structural diversity of their polysaccharides has hampered efforts to dissect the structure-activity relationships ...
Brown, Joshua M. +14 more
core +2 more sources
Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. [PDF]
, 2010 Topographic neuronal maps arise as a consequence of axon trajectory choice correlated with the localisation of neuronal soma, but the identity of the pathways coordinating these processes is unknown.
Kania, Artur +8 more
core +4 more sources
The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance [PDF]
, 2011 The multiprotein complexes that receive and transmit axon pathfinding cues during development are essential to circuit generation. Here, we identify and characterize the Drosophila sterile α-motif (SAM) domain-containing protein Caskin, which shares ...
Broihier, Heather T +3 more
core +2 more sources
Near-IR photometry of disk galaxies: search for nuclear isophotal twist and double bars [PDF]
, 1997 We present a near-IR, mainly H band, photometry of 72 nearby disk galaxies. The main goal of the survey was to search for isophotal twist inside their nuclear regions.
Axon, David J. +2 more
core +2 more sources
Determination of immunogenic proteins in biopharmaceuticals by UHPLC–MS amino acid analysis
BMC Chemistry, 2019 Nowadays, there is a growing interest in innovative and more efficient therapeutics—biopharmaceuticals, based on peptides or proteins. There are increased demands on quality control of such therapeutics.
Juraj Piestansky +4 more
doaj +1 more source
Axon, 2023 Axon è come una tessitura: le iscrizioni disegnano il profilo di un tema o di un contesto, e man mano che il corpus va crescendo contribuiscono ad arricchire un panorama già tratteggiato in qualche suo aspetto.
De Vido, Stefania
doaj +1 more source