Results 21 to 30 of about 304,829 (369)
Axonal transport during injury on a theoretical axon
Frontiers in Cellular Neuroscience, 2023 Neurodevelopment, plasticity, and cognition are integral with functional directional transport in neuronal axons that occurs along a unique network of discontinuous polar microtubule (MT) bundles. Axonopathies are caused by brain trauma and genetic diseases that perturb or disrupt the axon MT infrastructure and, with it, the dynamic interplay of motor ...
Soumyadeep Chandra +6 more
openaire +3 more sources
Axonal Odorant Receptors Mediate Axon Targeting [PDF]
Cell Reports, 2019 In mammals, odorant receptors not only detect odors but also define the target in the olfactory bulb, where sensory neurons project to give rise to the sensory map. The odorant receptor is expressed at the cilia, where it binds odorants, and at the axon terminal.
Claudia Lodovichi +13 more
openaire +6 more sources
Noninvasive quantification of axon radii using diffusion MRI
eLife, 2020 Axon caliber plays a crucial role in determining conduction velocity and, consequently, in the timing and synchronization of neural activation. Noninvasive measurement of axon radii could have significant impact on the understanding of healthy and ...
J. Veraart +6 more
semanticscholar +1 more source
Axon degeneration: Linking axonal bioenergetics to myelin [PDF]
Journal of Cell Biology, 2016 The mechanisms by which axonal degeneration occurs, even in the presence of apparently normal myelin sheaths, remain unknown. In this issue, Yin et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607099) study mutant mice in which proteolipid protein is replaced by the peripheral myelin protein P0 and describe a number of early axonal ...
Bogdan Beirowski +2 more
openaire +3 more sources
Advanced Engineering Materials, EarlyView., 2023 This study aims to explore the feasibility of using a structure inspired by the features of horsetail and human spine as the potential helmet liner, targeting at mitigation of acceleration‐induced injuries. A parametric study is conducted to investigate the effect of individual geometrical variables in the design, indicating its capability to reduce ...
Bing Leng +3 more
wiley +1 more source
Required growth facilitators propel axon regeneration across complete spinal cord injury
Nature, 2018 Transected axons fail to regrow across anatomically complete spinal cord injuries (SCI) in adults. Diverse molecules can partially facilitate or attenuate axon growth during development or after injury1–3, but efficient reversal of this regrowth failure ...
Mark A. Anderson +17 more
semanticscholar +1 more source
A mathematical model explains saturating axon guidance responses to molecular gradients
eLife, 2016 Correct wiring is crucial for the proper functioning of the nervous system. Molecular gradients provide critical signals to guide growth cones, which are the motile tips of developing axons, to their targets.
Huyen Nguyen +4 more
semanticscholar +1 more source
Injury-induced Cavl-expressing cells at lesion rostral side play major roles in spinal cord regeneration [PDF]
Open Biology, 2021 The extent of cellular heterogeneity involved in neuronal regeneration after spinal cord injury (SCI) remains unclear. Therefore, we established stress-responsive transgenic zebrafish embryos with SCI. As a result, we found an SCI-induced cell population,
Chih-Wei Zeng +4 more
doaj +1 more source
Modeling of interstitial branching of axonal networks [PDF]
1. J. Integr. Neurosci. 12, 1-14, (2013), 2013 A single axon can generate branches connecting with plenty synaptic targets. Process of branching is very important for making connections in central nervous system. The interstitial branching along primary axon shaft occurs during nervous system development. Growing axon makes pause in its movement and leaves active points behind its terminal. The new
arxiv +1 more source
Intersection of pathological tau and microglia at the synapse
Acta Neuropathologica Communications, 2019 Tauopathies are a heterogenous class of diseases characterized by cellular accumulation of aggregated tau and include diseases such as Alzheimer’s disease (AD), progressive supranuclear palsy and chronic traumatic encephalopathy.
Thomas Vogels +2 more
doaj +1 more source