A sulfated carbohydrate epitope inhibits axon regeneration after injury [PDF]
, 2012 Chondroitin sulfate proteoglycans (CSPGs) represent a major barrier to regenerating axons in the central nervous system (CNS), but the structural diversity of their polysaccharides has hampered efforts to dissect the structure-activity relationships ...
Brown, Joshua M. +14 more
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Frontiers in Aging Neuroscience, 2019 Alzheimer’s disease (AD), the most common tauopathy, is an age-dependent, progressive neurodegenerative disease. Epidemiological studies implicate the role of genetic background in the onset and progression of AD.
Tomas Smolek +11 more
doaj +1 more source
Intersection of pathological tau and microglia at the synapse
Acta Neuropathologica Communications, 2019 Tauopathies are a heterogenous class of diseases characterized by cellular accumulation of aggregated tau and include diseases such as Alzheimer’s disease (AD), progressive supranuclear palsy and chronic traumatic encephalopathy.
Thomas Vogels +2 more
doaj +1 more source
The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance [PDF]
, 2011 The multiprotein complexes that receive and transmit axon pathfinding cues during development are essential to circuit generation. Here, we identify and characterize the Drosophila sterile α-motif (SAM) domain-containing protein Caskin, which shares ...
Broihier, Heather T +3 more
core +2 more sources
Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. [PDF]
, 2010 Topographic neuronal maps arise as a consequence of axon trajectory choice correlated with the localisation of neuronal soma, but the identity of the pathways coordinating these processes is unknown.
Kania, Artur +8 more
core +4 more sources
The involvement of actin, calcium channels and exocytosis proteins in somato-dendritic oxytocin and vasopressin release [PDF]
, 2012 Hypothalamic magnocellular neurons release vasopressin and oxytocin not only from their axon terminals into the blood, but also from their somata and dendrites into the extracellular space of the brain, and this can be regulated independently ...
Leng, Gareth, Ludwig, Mike, Tobin, Vicky
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Intra-axonal mechanisms driving axon regeneration
Brain Research, 2020 Traumatic injury to the peripheral and central nervous systems very often causes axotomy, where an axon loses connections with its target resulting in loss of function. The axon segments distal to the injury site lose connection with the cell body and degenerate.
Terika P, Smith +3 more
openaire +3 more sources
Determination of immunogenic proteins in biopharmaceuticals by UHPLC–MS amino acid analysis
BMC Chemistry, 2019 Nowadays, there is a growing interest in innovative and more efficient therapeutics—biopharmaceuticals, based on peptides or proteins. There are increased demands on quality control of such therapeutics.
Juraj Piestansky +4 more
doaj +1 more source
Axonal Odorant Receptors Mediate Axon Targeting [PDF]
Cell Reports, 2019 In mammals, odorant receptors not only detect odors but also define the target in the olfactory bulb, where sensory neurons project to give rise to the sensory map. The odorant receptor is expressed at the cilia, where it binds odorants, and at the axon terminal.
Zamparo, Ilaria +12 more
openaire +4 more sources
Near-IR photometry of disk galaxies: search for nuclear isophotal twist and double bars [PDF]
, 1997 We present a near-IR, mainly H band, photometry of 72 nearby disk galaxies. The main goal of the survey was to search for isophotal twist inside their nuclear regions.
Axon, David J. +2 more
core +2 more sources