Results 71 to 80 of about 6,093,797 (222)

Application of Electrical Stimulation to Enhance Axon Regeneration Following Peripheral Nerve Injury

Bio-Protocol, 2023
Enhancing axon regeneration is a major focus of peripheral nerve injury research. Although peripheral axons possess a limited ability to regenerate, their functional recovery is very poor.
Supriya Wariyar, Patricia Ward
doaj   +1 more source

Charcot-Marie-Tooth 2b associated Rab7 mutations cause axon growth and guidance defects during vertebrate sensory neuron development

Neural Development, 2016
BackgroundCharcot-Marie-Tooth2b (CMT2b) is an axonal form of a human neurodegenerative disease that preferentially affects sensory neurons. CMT2b is dominantly inherited and is characterized by unusually early onset, presenting in the second or third ...
O. Y. Ponomareva, K. Eliceiri, M. Halloran   +2 more
semanticscholar   +1 more source

CSF Tau Is a Biomarker of Hippocampal Injury in Cryptogenic New‐Onset Refractory Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cryptogenic new‐onset refractory status epilepticus (cNORSE) is a devastating condition characterized by the de novo onset of status epilepticus with unclear etiology. The identification of relevant early biomarkers in cNORSE is important to elucidate pathophysiology, aid clinical decision‐making, and prognosticate outcomes in cNORSE.
Yihui Goh, Yoonhyuk Jang, Soo Jean Shin, Soo Hyun Ahn, Su Yee Mon, Yoon Hee Shin, Kon Chu, Sang Kun Lee, Soon‐Tae Lee   +8 more
wiley   +1 more source

Role of GSK3 signaling in neuronal morphogenesis

Frontiers in Molecular Neuroscience, 2011
Glycogen synthase kinase 3 (GSK3) is emerging as a key regulator of several aspects of neuronal morphogenesis including neuronal polarization, axon growth and axon branching.
Yun Tai eKim, Eun-Mi eHur, William D. Snider, Feng-Quan eZhou, Feng-Quan eZhou   +4 more
doaj   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Independent signaling by Drosophila insulin receptor for axon guidance and growth

Frontiers in Physiology, 2014
The Drosophila insulin receptor (DInR) regulates a diverse array of biological processes including growth, axon guidance, and sugar homeostasis. Growth regulation by DInR is mediated by Chico, the Drosophila homolog of vertebrate insulin-receptor ...
Caroline Rita Li, Dongyu eGuo, Leslie ePick   +2 more
doaj   +1 more source

Gene expression of axon growth promoting factors in the deer antler. [PDF]

PLoS ONE, 2010
The annual regeneration cycle of deer (Cervidae, Artiodactyla) antlers represents a unique model of epimorphic regeneration and rapid growth in adult mammals. Regenerating antlers are innervated by trigeminal sensory axons growing through the velvet, the
Wolfgang Pita-Thomas, Carmen Fernández-Martos, Mónica Yunta, Rodrigo M Maza, Rosa Navarro-Ruiz, Marcos Javier Lopez-Rodríguez, David Reigada, Manuel Nieto-Sampedro, Manuel Nieto-Diaz   +8 more
doaj   +1 more source

Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons

Scientific Reports, 2016
Leucine Zipper-bearing Kinase (LZK/MAP3K13) is a member of the mixed lineage kinase family with high sequence identity to Dual Leucine Zipper Kinase (DLK/MAP3K12). While DLK is established as a key regulator of axonal responses to injury, the role of LZK
Meifan Chen, Cédric G. Geoffroy, Hetty N. Wong, O. Tress, M. T. Nguyen, L. Holzman, Yishi Jin, B. Zheng   +7 more
semanticscholar   +1 more source

Importin 13-dependent axon diameter growth regulates conduction speeds along myelinated CNS axons

Nature Communications
Axon diameter influences the conduction properties of myelinated axons, both directly, and indirectly through effects on myelin. However, we have limited understanding of mechanisms controlling axon diameter growth in the central nervous system ...
Jenea M. Bin, Daumante Suminaite, Silvia K. Benito-Kwiecinski, Linde Kegel, Maria Rubio-Brotons, Jason J. Early, Daniel Soong, Matthew R. Livesey, Richard J. Poole, David A. Lyons   +9 more
doaj   +1 more source

A simple rule for axon outgrowth and synaptic competition generates realistic connection lengths and filling fractions [PDF]

Cerebral Cortex 2009 19(12):3001-3010, 2009
Neural connectivity at the cellular and mesoscopic level appears very specific and is presumed to arise from highly specific developmental mechanisms. However, there are general shared features of connectivity in systems as different as the networks formed by individual neurons in Caenorhabditis elegans or in rat visual cortex and the mesoscopic ...
arxiv   +1 more source