Results 71 to 80 of about 6,316,330 (345)

Required growth facilitators propel axon regeneration across complete spinal cord injury

Nature, 2018
Transected axons fail to regrow across anatomically complete spinal cord injuries (SCI) in adults. Diverse molecules can partially facilitate or attenuate axon growth during development or after injury1–3, but efficient reversal of this regrowth failure ...
Mark A. Anderson, T.M. O’Shea, J. Burda, Y. Ao, S. L. Barlatey, Alexander M. Bernstein, Jae H Kim, N. James, Alexandra Rogers, Brian Kato, A. L. Wollenberg, R. Kawaguchi, G. Coppola, Chen Wang, T. Deming, Zhigang He, G. Courtine, M. Sofroniew   +17 more
semanticscholar   +1 more source

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Syndecan Promotes Axon Regeneration by Stabilizing Growth Cone Migration

Cell Reports, 2014
Growth cones facilitate the repair of nervous system damage by providing the driving force for axon regeneration. Using single-neuron laser axotomy and in vivo time-lapse imaging, we show that syndecan, a heparan sulfate (HS) proteoglycan, is required ...
Tyson J. Edwards, Marc Hammarlund
doaj   +1 more source

Depending on its nano-spacing, ALCAM promotes cell attachment and axon growth. [PDF]

PLoS ONE, 2012
ALCAM is a member of the cell adhesion molecule (CAM) family which plays an important role during nervous system formation. We here show that the two neuron populations of developing dorsal root ganglia (DRG) display ALCAM transiently on centrally and ...
Karsten Thelen, Steffen Jaehrling, Joachim P Spatz, G Elisabeth Pollerberg   +3 more
doaj   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Independent signaling by Drosophila insulin receptor for axon guidance and growth

Frontiers in Physiology, 2014
The Drosophila insulin receptor (DInR) regulates a diverse array of biological processes including growth, axon guidance, and sugar homeostasis. Growth regulation by DInR is mediated by Chico, the Drosophila homolog of vertebrate insulin-receptor ...
Caroline Rita Li, Dongyu eGuo, Leslie ePick   +2 more
doaj   +1 more source

Increased Blood Levels of NfL, GFAP, and Placental Growth Factor After Radiotherapy to the Brain

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT In this study, we analyzed biomarkers of neuronal, glial, and vascular injury in longitudinal paired samples of blood and cerebrospinal fluid after prophylactic cranial irradiation in patients with small cell lung cancer. Neurofilament light chain protein (NfL) and glial fibrillary acidic protein (GFAP) increased in serum and cerebrospinal ...
Erik Fernström, Thomas Björk‐Eriksson, Pontus Erickson, Jan Nyman, Henrik Zetterberg, Marie Kalm   +5 more
wiley   +1 more source

Role of GSK3 signaling in neuronal morphogenesis

Frontiers in Molecular Neuroscience, 2011
Glycogen synthase kinase 3 (GSK3) is emerging as a key regulator of several aspects of neuronal morphogenesis including neuronal polarization, axon growth and axon branching.
Yun Tai eKim, Eun-Mi eHur, William D. Snider, Feng-Quan eZhou, Feng-Quan eZhou   +4 more
doaj   +1 more source

Charcot-Marie-Tooth 2b associated Rab7 mutations cause axon growth and guidance defects during vertebrate sensory neuron development

Neural Development, 2016
BackgroundCharcot-Marie-Tooth2b (CMT2b) is an axonal form of a human neurodegenerative disease that preferentially affects sensory neurons. CMT2b is dominantly inherited and is characterized by unusually early onset, presenting in the second or third ...
O. Y. Ponomareva, K. Eliceiri, M. Halloran   +2 more
semanticscholar   +1 more source

Axon guidance by growth-rate modulation [PDF]

Proceedings of the National Academy of Sciences, 2010
Guidance of axons by molecular gradients is crucial for wiring up the developing nervous system. It often is assumed that the unique signature of such guidance is immediate and biased turning of the axon tip toward or away from the gradient. However, here we show that such turning is not required for guidance.
Mortimer, Duncan, Pujic, Zac, Vaughan, Timothy, Thompson, Andrew W., Feldner, Julia, Vetter, Irina, Goodhill, Geoffrey J.   +6 more
openaire   +3 more sources