Results 91 to 100 of about 104,244 (349)

Plexin B3 guides axons to cross the midline in vivo

Frontiers in Cellular Neuroscience
During the development of neural circuits, axons are guided by a variety of molecular cues to navigate through the brain and establish precise connections with correct partners at the right time and place. Many axon guidance cues have been identified and
Zhi-Zhi Liu, Zhi-Zhi Liu, Zhi-Zhi Liu, Zhi-Zhi Liu, Ling-Yan Liu, Ling-Yan Liu, Ling-Yan Liu, Ling-Yan Liu, Lou-Yin Zhu, Lou-Yin Zhu, Jian Zhu, Jian Zhu, Jia-Yu Luo, Jia-Yu Luo, Jia-Yu Luo, Jia-Yu Luo, Ye-Fan Wang, Ye-Fan Wang, Hong A. Xu, Hong A. Xu, Hong A. Xu, Hong A. Xu   +21 more
doaj   +1 more source

A Self‐Curling Si3N4‐Biofunctionalized Nerve Wrap for Suture‐Free Peripheral Nerve Repair with Multimodal Regenerative Bioregulation

Advanced Functional Materials, EarlyView.
Si3N4‐enhanced bioactive nanostructured adhesive wrap enables rapid conduit formation in wet environments, simplifying surgical procedures. Incorporated Si3N4 undergoes controlled hydrolysis within nanofibers, multi‐directionally modulating the peripheral nerve repair microenvironment for effective suture‐free repair.
Pengchao Ma, Yihao Liu, Bowen Ren, Chun‐Yi Yang, Xiaobin Luo, Peilun Hu, Jia Yang, Zheng Cao, Keya Mao, Jianheng Liu, Xiumei Wang   +10 more
wiley   +1 more source

The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb

Molecular Neurodegeneration, 2011
Background The β-secretase, β-site amyloid precursor protein cleaving enzyme 1 (BACE1), is a prime therapeutic target for lowering cerebral β-amyloid (Aβ) levels in Alzheimer's disease (AD).
Rajapaksha Tharinda W, Eimer William A, Bozza Thomas C, Vassar Robert   +3 more
doaj   +1 more source

DIP-2 suppresses ectopic neurite sprouting and axonal regeneration in mature neurons. [PDF]

, 2019
Neuronal morphology and circuitry established during early development must often be maintained over the entirety of animal lifespans. Compared with neuronal development, the mechanisms that maintain mature neuronal structures and architecture are little
Andrew D. Chisholm, Antonio Colavita, Carr, Chalfie, Chen, Chen, Chen, Coleman, Dickinson, Emoto, Finn, Hammarlund, Hayashi, Jan, Lee, Li, Li, Matter, Mukhopadhyay, Nathaniel Noblett, Nitta, Ouchi, Pan, Sanchez-Alvarez, Schmelz, Seungmee Park, Stephane Flibotte, Tank, Thorvaldsdóttir, Tony Roenspies, Toth, Wu, Yan, Yishi Jin, Zhang, Zhao Hua Ding, Zilu Wu   +36 more
core   +1 more source

Peptide Sequencing With Single Acid Resolution Using a Sub‐Nanometer Diameter Pore

Advanced Functional Materials, EarlyView.
To sequence a single molecule of Aβ1−42–sodium dodecyl sulfate (SDS), the aggregate is forced through a sub‐nanopore 0.4 nm in diameter spanning a 4.0 nm thick membrane. The figure is a visual molecular dynamics (VMD) snapshot depicting the translocation of Aβ1−42–SDS through the pore; only the peptide, the SDS, the Na+ (yellow/green) and Cl− (cyan ...
Apurba Paul, Archith Rayabharam, Lisa Almonte, Eveline Rigo, Joshy Joseph, Ashutosh Kumar, Zhuxin Dong, Narayana Aluru, Gregory Timp   +8 more
wiley   +1 more source

Role of Netrin-1 Signaling in Nerve Regeneration. [PDF]

, 2017
Netrin-1 was the first axon guidance molecule to be discovered in vertebrates and has a strong chemotropic function for axonal guidance, cell migration, morphogenesis and angiogenesis.
Cajal, Cajal, Cajal, David Parkinson, Jaminet, Ke, Lai Wing Sun, Lehmann, Manitt, Nakashiba, Tsukamoto, Xin-Peng Dun   +11 more
core   +3 more sources

A Van der Waals Optoelectronic Synapse with Tunable Positive and Negative Post‐Synaptic Current for Highly Accurate Spiking Neural Networks

Advanced Functional Materials, EarlyView.
A van der Waals optoelectronic synaptic device based on a ReS2/WSe2 heterostructure and oxygen‐treated h‐BN is presented, which enables both positive and negative PSCs through photocarrier polarity reversal. Bidirectional plasticity arises from gate‐tunable band bending and charge trapping‐induced quasi‐doping.
Hyejin Yoon, Soeun Park, Yeong Kwon Kim, Juhwan Baek, Ki Han Kim, Seongil Yun, Hyeonchang Son, Jeongeun Choi, Byung Chul Jang, Dong‐Ho Kang   +9 more
wiley   +1 more source

Drosophila Tet Is Expressed in Midline Glia and Is Required for Proper Axonal Development

Frontiers in Cellular Neuroscience, 2019
Ten-Eleven Translocation (TET) proteins are important epigenetic regulators that play a key role in development and are frequently deregulated in cancer.
Joy N. Ismail, Joy N. Ismail, Shireen Badini, Shireen Badini, Felice Frey, Felice Frey, Wassim Abou-Kheir, Margret Shirinian, Margret Shirinian   +8 more
doaj   +1 more source

NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance

Nature Communications, 2020
Robo3 is a divergent, multifunctional member of the Robo receptor family that mediates axon guidance by its ligand NELL2 instead of the canonical Slit ligands.
Joseph S. Pak, Zachary J. DeLoughery, Jing Wang, Nischal Acharya, Yeonwoo Park, Alexander Jaworski, Engin Özkan   +6 more
doaj   +1 more source

SnapShot: Axon Guidance II

Cell, 2013
BMP SE Repulsion BMP-RIB, BMP-RII - -COFILIN, LIMK1, PI3K, SMAD1, SMAD6DRAXIN SE Repulsion DCC - - -EPHRINA GPI Repulsion EPHA ADAM10 -a2-CHIMAERIN, EPHEXIN-1, NCK1/2, RAC1, RHOA, SPAR, VAV2/3EPHRINB TM Repulsion EPHB MMP2/9 -NCK1, PAK, p120GAP, RHOA, ROCK, VAV2/3EPHATM Repulsion EPHRINA ADAM10 P75 FYNAttraction EPHRINA - RET -EPHB TM Repulsion EPHRINB
Kolodkin, Alex L., Pasterkamp, R. Jeroen
openaire   +2 more sources