Results 91 to 100 of about 105,575 (349)

Labyrinthine Turing Pattern Formation in the Cerebral Cortex [PDF]

, 2002
I propose that the labyrinthine patterns of the cortices of mammalian brains may be formed by a Turing instability of interacting axonal guidance species acting together with the mechanical strain imposed by the interconnecting axons.Comment: See home ...
BAIER, BARD, CARTWRIGHT, CASTETS, DICKSTEIN, DOBYNS, ERNST, FITZHUGH, FITZHUGH, GOLDSTEIN, GOODHILL, GOODWIN, GRIFFIN, HENTSCHEL, JUDD, JULYAN H.E. CARTWRIGHT, KAUFFMAN, KOCH, KONDO, MEINHARDT, MURATOV, MURRAY, MURRAY, NAGUMO, ODELL, OSTER, OUYANG, RAGHAVAN, RAKIC, RAMÓN Y CAJAL, RICHMAN, SCANNELL, SEUL, TESSIER-LAVIGNE, TODD, TURING, VAN DER POL, VAN ESSEN, WATZL, WITELSON, ZHENG, ZILLES   +41 more
core   +3 more sources

Microfluidic control of axonal guidance [PDF]

Scientific Reports, 2014
The precision of axonal pathfinding and the accurate formation of functional neural circuitry are crucial for an organism during development as well as during adult central and peripheral nerve regeneration. While chemical cues are believed to be primarily responsible for axonal pathfinding, we hypothesize that forces due to localized fluid flow may ...
Gu, Ling, Black, Bryan, Ordonez, Simon, Mondal, Argha, Jain, Ankur, Mohanty, Samarendra   +5 more
openaire   +2 more sources

Region‐to‐Region Unidirectional Connection In Vitro Brain Model for Studying Directional Propagation of Neuropathologies

Advanced Functional Materials, EarlyView.
A unidirectional cerebral organoid–organoid neural circuit is established using a microfluidic platform, enabling controlled directional propagation of electrical signals, neuroinflammatory cues, and neurodegenerative disease–related proteins between spatially separated organoids.
Kyeong Seob Hwang, Hui‐Wen Liu, Hyogeun Shin, Hyun Wook Kang, Minjin Kang, Jongbaeg Kim, Il‐Joo Cho, Nakwon Choi, Seok Chung, Hong Nam Kim   +9 more
wiley   +1 more source

Plexin B3 guides axons to cross the midline in vivo

Frontiers in Cellular Neuroscience
During the development of neural circuits, axons are guided by a variety of molecular cues to navigate through the brain and establish precise connections with correct partners at the right time and place. Many axon guidance cues have been identified and
Zhi-Zhi Liu, Zhi-Zhi Liu, Zhi-Zhi Liu, Zhi-Zhi Liu, Ling-Yan Liu, Ling-Yan Liu, Ling-Yan Liu, Ling-Yan Liu, Lou-Yin Zhu, Lou-Yin Zhu, Jian Zhu, Jian Zhu, Jia-Yu Luo, Jia-Yu Luo, Jia-Yu Luo, Jia-Yu Luo, Ye-Fan Wang, Ye-Fan Wang, Hong A. Xu, Hong A. Xu, Hong A. Xu, Hong A. Xu   +21 more
doaj   +1 more source

Common variation near ROBO2 is associated with expressive vocabulary in infancy [PDF]

, 2014
Twin studies suggest that expressive vocabulary at ~24 months is modestly heritable. However, the genes influencing this early linguistic phenotype are unknown. Here we conduct a genome-wide screen and follow-up study of expressive vocabulary in toddlers
Ang, Qi W., Cents, Rolieke A. M., Dale, Philip S., Davis, Oliver S. P., Evans, David M., Golding, Jean, Haworth, Claire M. A., Hofman, A., Jaddoe, Vincent Wilfred Vishal-Kapoor, Jarvelin, Marjo-Riitta, Kemp, John P., Meaburn, Emma L., Miller, Laura, O’Reilly, Paul F., Pennell, Craig E., Pillas, Demetris, Plomin, Robert, Price, Tom S., Ring, Susan M., Rivadeneira, Fernando, Rodriguez, Alina, Roulstone, Susan, Smith, George Davey, St Pourcain, Beate, Tiemeier, Henning, Timpson, Nicholas J., Velders, F. P., Verhulst, F. C., Warrington, Nicole M., Whitehouse, Andrew J. O., Wren, Yvonne, Yliherva, Anneli   +31 more
core   +9 more sources

A Van der Waals Optoelectronic Synapse with Tunable Positive and Negative Post‐Synaptic Current for Highly Accurate Spiking Neural Networks

Advanced Functional Materials, EarlyView.
A van der Waals optoelectronic synaptic device based on a ReS2/WSe2 heterostructure and oxygen‐treated h‐BN is presented, which enables both positive and negative PSCs through photocarrier polarity reversal. Bidirectional plasticity arises from gate‐tunable band bending and charge trapping‐induced quasi‐doping.
Hyejin Yoon, Soeun Park, Yeong Kwon Kim, Juhwan Baek, Ki Han Kim, Seongil Yun, Hyeonchang Son, Jeongeun Choi, Byung Chul Jang, Dong‐Ho Kang   +9 more
wiley   +1 more source

The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb

Molecular Neurodegeneration, 2011
Background The β-secretase, β-site amyloid precursor protein cleaving enzyme 1 (BACE1), is a prime therapeutic target for lowering cerebral β-amyloid (Aβ) levels in Alzheimer's disease (AD).
Rajapaksha Tharinda W, Eimer William A, Bozza Thomas C, Vassar Robert   +3 more
doaj   +1 more source

Astrocyte‐Guided Maturation of Neural Constructs in a Modular Biosynthetic Hydrogel for Biohybrid Neurotechnologies

Advanced Functional Materials, EarlyView.
A modular biosynthetic PVA–gelatin hydrogel crosslinked via visible‐light thiol‐ene chemistry is engineered as a coating for neural electrodes. Optimizing matrix composition and mechanical properties enables the hydrogel to support astrocytic populations that guide neural differentiation and functional maturation.
Martina Genta, Sofia Peressotti, Roberto Portillo‐Lara, Josef Goding, Rylie Green   +4 more
wiley   +1 more source

Drosophila Tet Is Expressed in Midline Glia and Is Required for Proper Axonal Development

Frontiers in Cellular Neuroscience, 2019
Ten-Eleven Translocation (TET) proteins are important epigenetic regulators that play a key role in development and are frequently deregulated in cancer.
Joy N. Ismail, Joy N. Ismail, Shireen Badini, Shireen Badini, Felice Frey, Felice Frey, Wassim Abou-Kheir, Margret Shirinian, Margret Shirinian   +8 more
doaj   +1 more source

A simple rule for axon outgrowth and synaptic competition generates realistic connection lengths and filling fractions [PDF]

, 2009
Neural connectivity at the cellular and mesoscopic level appears very specific and is presumed to arise from highly specific developmental mechanisms.
Achacoso, Amirikian, Arjen van Ooyen, Baruch, Binzegger, Borisyuk, Braitenberg, Butz, Cabelli, Carmichael, Chklovskii, Choe, Claus C. Hilgetag, Costa, Costa, Crepel, Easter, Felleman, Hellwig, Hellwig, Hilgetag, Hume, Kaiser, Kaiser, Kaiser, Kaiser, Kalisman, Kaufman, Kisvarday, Kötter, LaMantia, Lewis, Lohmann, Lohof, Marcus Kaiser, McGuire, Murray, Nisbach, Purves, Rakic, Rakic, Rakic, Rakic, Rakic, Samsonovich, Sanes, Sperry, Sporns, Stepanyants, Stephan, Stephan, Tarui, Uylings, van Ooyen, van Ooyen, van Ooyen, van Ooyen, van Ooyen, van Ooyen A, Verhage, Watts, Wen, White, Wiesel, Yamamoto   +64 more
core   +2 more sources