Results 111 to 120 of about 902,976 (291)

Signaling mechanisms in cortical axon growth, guidance and branching

Frontiers in Neuroanatomy, 2011
Precise wiring of cortical circuits during development depends upon axon extension, guidance and branching to appropriate targets. Motile growth cones at axon tips navigate through the nervous system by responding to molecular cues, which modulate ...
Katherine eKalil, Katherine eKalil, Li eLi, Li eLi, B.Ian eHutchins, B.Ian eHutchins   +5 more
doaj   +1 more source

Axon Guidance: Gained in Translation [PDF]

Neuron, 2018
In this issue of Neuron, Cagnetta et al. (2018) describe a novel method to identify, in an unbiased manner, newly synthesized axonal proteins in response to axon guidance cues. They find that axons stimulated by different guidance cues (Netrin-1, BDNF, and Sema3A) show distinct and common signatures.
openaire   +2 more sources

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Commissural axon guidance in the developing spinal cord: from Cajal to the present day

Neural Development, 2019
During neuronal development, the formation of neural circuits requires developing axons to traverse a diverse cellular and molecular environment to establish synaptic contacts with the appropriate postsynaptic partners.
J. D. Comer, S. Alvarez, S. J. Butler, J. A. Kaltschmidt   +3 more
doaj   +1 more source

Axon guidance by growth-rate modulation

, 2010
Guidance of axons by molecular gradients is crucial for wiring up the developing nervous system. It often is assumed that the unique signature of such guidance is immediate and biased turning of the axon tip toward orawayfrom the gradient.
G. J. Goodhill, Goodhill, G. J., D. Mortimer, Feldner, J., Vetter, I., I. Vetter, Pujic, Z., Z. Pujic, J. Feldner, Mortimer, D., A. W. Thompson, T. Vaughan, Vaughan, T., Thompson, A. W.   +13 more
core   +1 more source

RGMa and RGMb expression pattern during chicken development suggest unexpected roles for these repulsive guidance molecules in notochord formation, somitogenesis, and myogenesis [PDF]

, 2012
Background: Repulsive guidance molecules (RGM) are high-affinity ligands for the Netrin receptor Neogenin, and they are crucial for nervous system development including neural tube closure; neuronal and neural crest cell differentiation and axon guidance.
Coutinho, L., Ahmed, Mohi, Jorge, Erika Cristina, Dietrich, Susanne, Bothe, I., Ahmed, Mohi U., Coutinho, Luiz Lehmman, Ahmed, M., Bothe, Ingo, Jorge, E.   +9 more
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Regulation of subcellular dendritic synapse specificity by axon guidance cues

eLife, 2019
Neural circuit assembly occurs with subcellular precision, yet the mechanisms underlying this precision remain largely unknown. Subcellular synaptic specificity could be achieved by molecularly distinct subcellular domains that locally regulate synapse ...
Emily C Sales, Emily L Heckman, Timothy L Warren, Chris Q Doe   +3 more
doaj   +1 more source

Magnetoelectric Nanoparticle‐Based Wireless Brain–Computer Interface: Underlying Physics and Projected Technology Pathway

Advanced Science, EarlyView.
Magnetoelectric nanoparticles (MENPs) enable fully wireless, minutely invasive neuromodulation, and potentially neural recording, by converting magnetic into electric and, conversely, electric into magnetic fields, respectively, at high spatiotemporal resolution.
Elric Zhang, Max Shotbolt, Mostafa Abdel‐Mottaleb, Shawnus Chen, Victoria Andre, Jieyuan Tian, Jonathan Shulgach, Max Murphy, Brian Noga, Ping Liang, Darcy Griffin, Douglas Weber, Marta Pardo, Salvador Pane, Sakhrat Khizroev   +14 more
wiley   +1 more source

Chick PTPσ regulates the targeting of retinal axons within the optic tectum [PDF]

, 2002
Chick PTP (cPTP), also known as CRYP, is a receptor-like protein tyrosine phosphatase found on axons and growth cones. Putative ligands for cPTP are distributed within basement membranes and on glial end feet of the retina, optic nerve, and optic tectum,
Aricescu, AR, Aricescu, Alexandru, Rashid-Doubell, F, McKinnell, I, Sajnani, G, Stoker, A   +5 more
core