Results 91 to 100 of about 902,976 (291)
Neuropilin-mediated neural crest cell guidance is essential to organise sensory neurons into segmented dorsal root ganglia [PDF]
, 2009 The peripheral nervous system (PNS) of higher vertebrates is segmented to align the spinal nerve roots with the vertebrae. This co-patterning is set up during embryogenesis, when vertebrae develop from the sclerotome layer of the metameric somites, and ...
Maden, CH +11 more
core +1 more source
Advanced Materials, EarlyView.Using a bottom‐up approach, we engineered a human neuromuscular microchip to investigate distinct adaptive responses to neural stimulation and metabolic stress. Further integration of endothelial cells revealed their critical role in modulating neuromuscular excitability, establishing a comprehensive neurovascular‐muscular model.
Jinchul Ahn +17 more
wiley +1 more source
Olfactory axon guidance: the modified rules
, 2011 The olfactory system represents a complex model for the investigation of factors that influence the guidance of sensory axon populations to specific targets in the CNS.
Henion, Timothy R. +1 more
core +1 more source
Motor axon guidance in Drosophila
Seminars in Cell & Developmental Biology, 2019 The Drosophila motor system starts to assemble during embryonic development. It is composed of 30 muscles per abdominal hemisegment and 36 motor neurons assembling into nerve branches to exit the CNS, navigate within the muscle field and finally establish specific connections with their target muscles. Several families of guidance molecules that play a
Aref, Arzan Zarin, Juan-Pablo, Labrador
openaire +4 more sources
Advanced Science, EarlyView.NeuroSuite provides a modular hardware‐software platform integrating Neuroweb and NeuroMaps to enable long‐term, in situ electrophysiological interrogation of air–liquid interface organoid slices while preserving tissue architecture. Its components can be used together or independently to capture real‐time activity, spatial network dynamics, and ...
Belquis Haider +14 more
wiley +1 more source
Molecular Neurodegeneration, 2011 Background The β-secretase, β-site amyloid precursor protein cleaving enzyme 1 (BACE1), is a prime therapeutic target for lowering cerebral β-amyloid (Aβ) levels in Alzheimer's disease (AD).
Rajapaksha Tharinda W +3 more
doaj +1 more source
Postembryonic sensory axon guidance in Drosophila
, 1999 The peripheral sensory system of the Drosophila adult has been used for the genetic analysis of axon guidance because of its accessibility for experimental manipulation and mutant screens.
García-Alonso, Luis
core +1 more source
Axon guidance in the inner ear
The International Journal of Developmental Biology, 2007 Statoacoustic ganglion (SAG) neurons send their peripheral processes to navigate into the inner ear sensory organs where they will ultimately become post-synaptic to mature hair cells. During early ear development, neuroblasts delaminate from a restricted region of the ventral otocyst and migrate to form the SAG.
Donna M, Fekete, Andrea M, Campero
openaire +3 more sources
Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV
Advanced Science, EarlyView.Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes +14 more
wiley +1 more source
NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance
Nature Communications, 2020 Robo3 is a divergent, multifunctional member of the Robo receptor family that mediates axon guidance by its ligand NELL2 instead of the canonical Slit ligands.
Joseph S. Pak +6 more
doaj +1 more source