Results 91 to 100 of about 1,064,643 (248)

Drosophila Tet Is Expressed in Midline Glia and Is Required for Proper Axonal Development

Frontiers in Cellular Neuroscience, 2019
Ten-Eleven Translocation (TET) proteins are important epigenetic regulators that play a key role in development and are frequently deregulated in cancer.
Joy N. Ismail, Joy N. Ismail, Shireen Badini, Shireen Badini, Felice Frey, Felice Frey, Wassim Abou-Kheir, Margret Shirinian, Margret Shirinian   +8 more
doaj   +1 more source

Signaling mechanism of the netrin-1 receptor DCC in axon guidance

Progress in Biophysics and Molecular Biology, 2015
DCC (Deleted in Colorectal Cancer) is a single-pass transmembrane protein that belongs to the immunoglobulin superfamily. It was originally identified as a prognostic tumor marker and then subsequently found to be a receptor for netrin-1. DCC plays a key
L. Finci, L. Finci, Yan Zhang, R. Meijers, Jia-huai Wang, Jia-huai Wang   +5 more
semanticscholar   +1 more source

Guidance of retinal axons in mammals

Seminars in Cell & Developmental Biology, 2019
In order to navigate through the surrounding environment many mammals, including humans, primarily rely on vision. The eye, composed of the choroid, sclera, retinal pigmented epithelium, cornea, lens, iris and retina, is the structure that receives the light and converts it into electrical impulses.
Herrera E, Erskine L, Morenilla-Palao C
openaire   +4 more sources

Bias‐Field Free Single‐Frequency CW‐ODMR of Nitrogen‐Vacancy Centers in Diamond for the Detection of Transient Electrical Signals

Advanced Materials Interfaces, EarlyView.
Simplified quantum sensing technique for the detection of short electrical signals occurring in neuronal signaling or bioinspired technologies. We demonstrate a single frequency continuous‐wave optically detected magnetic resonance (CW‐ODMR) approach to sense signals that can be as short as 0.2 ms.
João Paulo Silva, Orlando D. Cunha, Pedro Magalhães, Filipe Camarneiro, Jana B. Nieder   +4 more
wiley   +1 more source

Passive microfluidic chamber for long-term imaging of axon guidance in response to soluble gradients

Lab on a Chip, 2015
Understanding how axons are guided to target locations within the brain is of fundamental importance for neuroscience, and is a widely studied area of research. Biologists have an unmet need for reliable and easily accessible methods that generate stable,
Anne Taylor, Shalini Menon, S. Gupton
semanticscholar   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

SnapShot: Axon Guidance II

Cell, 2013
BMP SE Repulsion BMP-RIB, BMP-RII - -COFILIN, LIMK1, PI3K, SMAD1, SMAD6DRAXIN SE Repulsion DCC - - -EPHRINA GPI Repulsion EPHA ADAM10 -a2-CHIMAERIN, EPHEXIN-1, NCK1/2, RAC1, RHOA, SPAR, VAV2/3EPHRINB TM Repulsion EPHB MMP2/9 -NCK1, PAK, p120GAP, RHOA, ROCK, VAV2/3EPHATM Repulsion EPHRINA ADAM10 P75 FYNAttraction EPHRINA - RET -EPHB TM Repulsion EPHRINB
Kolodkin, Alex L., Pasterkamp, R. Jeroen
openaire   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

Advanced Science, EarlyView.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei, Jiaying Shi, Jing Xi, Yixiang Xu, Shuye Ying, Xukun Fan, Wangjialu Lu, Zhisheng Li, Menghan Li, Yu Wang, Li Cheng, Lin Yang, Lingyu Xu, Zhong Chen, Cenglin Xu, Yi Wang   +15 more
wiley   +1 more source

Revisiting Netrin-1: One Who Guides (Axons)

Frontiers in Cellular Neuroscience, 2018
Proper patterning of the nervous system requires that developing axons find appropriate postsynaptic partners; this entails microns to meters of extension through an extracellular milieu exhibiting a wide range of mechanical and chemical properties. Thus,
Nicholas P. Boyer, Stephanie L. Gupton, Stephanie L. Gupton   +2 more
doaj   +1 more source