Results 141 to 150 of about 50,714 (254)

Axon guidance genes modulate neurotoxicity of ALS-associated UBQLN2. [PDF]

Elife, 2023
Kim SH, Nichols KD, Anderson EN, Liu Y, Ramesh N, Jia W, Kuerbis CJ, Scalf M, Smith LM, Pandey UB, Tibbetts RS.   +10 more
europepmc   +1 more source

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

FGF-Mediated Axon Guidance: Role of Downstream Signaling Pathways in Cytoskeletal Control. [PDF]

Cells
Li J, Gao H, Liu F.
europepmc   +1 more source

An Innervated Human Skin Equivalent that Electrically Encodes Mechanical and Thermal Stimuli

Advanced Science, EarlyView.
An innervated human skin equivalent is integrated with high‐density microelectrode arrays to reveal how engineered free nerve ending–like structures translate touch and temperature into electrical codes. Mechanical indentation and thermal stimulation engage the engineered somatosensory circuitry and evoke distinct firing and waveform signatures ...
Daniele Bellantoni, Costantino Casale, Marika Sperduti, Nevio L. Tagliamonte, Giorgia Imparato, Loredana Zollo, Paolo A. Netti   +6 more
wiley   +1 more source

Axon guidance cue SLIT2 regulates the murine skeletal stem cell niche through sympathetic innervation. [PDF]

J Clin Invest
Wu Z, Li N, Luo Z, Chen Z, He X, Han J, Lin X, Shi F, Huang H, Shi B, Li Y, Wang X, Meng L, Zhang D, Chen L, Zhou D, Cheng W, Greenblatt MB, Xu R.   +18 more
europepmc   +1 more source

A tug of war between DCC and ROBO1 signaling during commissural axon guidance. [PDF]

Cell Rep, 2023
Dailey-Krempel B, Martin AL, Jo HN, Junge HJ, Chen Z.   +4 more
europepmc   +1 more source

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

Mex3a-dependent post-transcriptional silencing ensures olfactory receptor diversity and axon guidance specificity. [PDF]

Cell Rep
Duffié R, Shayya H, Escamilla Del Arenal M, Wang M, Kahiapo J, Ugurbil A, Keskin A, Clowney F, Bashkirova EV, Pourmorady AD, Schieren I, Avila HI, Berchowitz LE, Barriga FM, Batlle E, Jovanovic M, Lomvardas S.   +16 more
europepmc   +1 more source

Regulation of Axon Guidance by Slit2 and Netrin-1 Signaling in the Lacrimal Gland of Aqp5 Knockout Mice. [PDF]

Invest Ophthalmol Vis Sci, 2023
Bai Y, Di G, Ge H, Li B, Zhang K, Zhang D, Wang D, Chen P.   +7 more
europepmc   +1 more source

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

Advanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li, Na Qiu, Chao Zhou, Andrew Ni, Ping Sun, Jia‐Jun Liu, Xin‐Lei Huang, Tian‐Qing Xiong, Yu‐Chi Zhang, Hai‐Zhou Liu, Xiao‐Tao Xu, Rui Wang, Shi‐Qing Zhang, Yu‐Xin Zhang, Silvia Liu, C. Edward Dixon, Jun Chen, Ke‐Jie Yin   +17 more
wiley   +1 more source