Results 51 to 60 of about 57,333 (280)

MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon

Cell Reports, 2019
Summary: The motor protein kinesin-1 plays an important role in polarized sorting of transport vesicles to the axon. However, the mechanism by which the axonal entry of kinesin-1-dependent cargo transport is regulated remains unclear.
Xingxiu Pan, Yujie Cao, Riccardo Stucchi, Peter Jan Hooikaas, Sybren Portegies, Lena Will, Maud Martin, Anna Akhmanova, Martin Harterink, Casper C. Hoogenraad   +9 more
doaj   +1 more source

Neurofascin and Kv7.3 are delivered to somatic and axon terminal surface membranes en route to the axon initial segment

eLife, 2020
Ion channel complexes promote action potential initiation at the mammalian axon initial segment (AIS), and modulation of AIS size by recruitment or loss of proteins can influence neuron excitability.
Aniket Ghosh, Elise LV Malavasi, Diane L Sherman, Peter J Brophy   +3 more
doaj   +1 more source

Nanodiamonds-induced effects on neuronal firing of mouse hippocampal microcircuits [PDF]

, 2018
Fluorescent nanodiamonds (FND) are carbon-based nanomaterials that can efficiently incorporate optically active photoluminescent centers such as the nitrogen-vacancy complex, thus making them promising candidates as optical biolabels and drug-delivery ...
Battiato, A., Calorio, C., Carabelli, V., Carbone, E., Forneris, J., Gai, M., Gavello, D., Genovese, M., Guarina, L., Marcantoni, A., Moreva, E., Olivero, P., Picollo, F., Tchernij, S. Ditalia, Traina, P.   +14 more
core   +4 more sources

Feedback-Driven Assembly of the Axon Initial Segment [PDF]

Neuron, 2019
The axon initial segment (AIS) is a unique neuronal compartment that plays a crucial role in the generation of action potential and neuronal polarity. The assembly of the AIS requires membrane, scaffolding, and cytoskeletal proteins, including Ankyrin-G and TRIM46. How these components cooperate in AIS formation is currently poorly understood. Here, we
Fréal, Amélie, Rai, Dipti, Tas, Roderick P, Pan, Xingxiu, Katrukha, Eugene A, van de Willige, Dieudonnée, Stucchi, Riccardo, Aher, Amol, Yang, Chao, Altelaar, A F Maarten, Vocking, Karin, Post, Jan Andries, Harterink, Martin, Kapitein, Lukas C, Akhmanova, Anna, Hoogenraad, Casper C   +15 more
openaire   +7 more sources

The Role of Parvalbumin-positive Interneurons in Auditory Steady-State Response Deficits in Schizophrenia [PDF]

, 2019
© The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the ...
A.M. Lavoie, AR Woodruff, C Börgers, C-G Hahn, CA Brenner, Chi-Ming A. Chen, CL Beasley, D Vierling-Claassen, D Vierling-Claassen, David A. Lewis, David W. Volk, E Salinas, G Gonzalez-Burgos, GA Light, GP Krishnan, Hanna Thuné, Henry Markram, I Wonodi, J. Szabadics, Joshua T. Kantrowitz, JS Kwon, KM Spencer, KM Spencer, KM Spencer, L KRISTIANSEN, LS Overstreet, M Bartos, M Carlén, Monica Beneyto, Monika P. Jadi, MW Howard, N Hajos, Nadezhda V. Povysheva, P Fries, P Steullet, P Teale, Pascal Fries, R Tsuchimoto, Robin Tremblay, RY Cho, S Keros, T Hashimoto, T Mäki-Marttunen, T-U Woo, Tuomo Mäki-Marttunen, Y Kawaguchi   +45 more
core   +2 more sources

A control algorithm for autonomous optimization of extracellular recordings [PDF]

, 2006
This paper develops a control algorithm that can autonomously position an electrode so as to find and then maintain an optimal extracellular recording position.
Burdick, Joel W., Nenadic, Zoran
core   +2 more sources

Consciousness and spintronic coherence in microtubules

Communicative & Integrative Biology
Microtubules are nanoscale spintronic oscillators with memristive properties. Spintronic and memristive effects, together with some unique conditions found in the axon initial segment (AIS), allow quantum coherence to emerge spontaneously in a population
Majid Beshkar
doaj   +1 more source

Cerebellar Golgi cell models predict dendritic processing and mechanisms of synaptic plasticity.

PLoS Computational Biology, 2020
The Golgi cells are the main inhibitory interneurons of the cerebellar granular layer. Although recent works have highlighted the complexity of their dendritic organization and synaptic inputs, the mechanisms through which these neurons integrate complex
Stefano Masoli, Alessandra Ottaviani, Stefano Casali, Egidio D'Angelo   +3 more
doaj   +1 more source

Spikelets in Pyramidal Neurons: Action Potentials Initiated in the Axon Initial Segment That Do Not Activate the Soma. [PDF]

PLoS Computational Biology, 2017
Spikelets are small spike-like depolarizations that can be measured in somatic intracellular recordings. Their origin in pyramidal neurons remains controversial.
Martina Michalikova, Michiel W H Remme, Richard Kempter   +2 more
doaj   +1 more source

In vivo assembly of the axon initial segment in motor neurons [PDF]

, 2013
International audienceThe axon initial segment (AIS) is responsible for both the modulation of action potentials and the maintenance of neuronal polarity. Yet, the molecular mechanisms controlling its assembly are incompletely understood.
A Delpy, A Duflocq, A Iwakura, A Lorincz, AH Song, AL Scain, Amélie Fréal, Antonny Czarnecki, AP Barnes, B Winckler, B Zonta, Barbara Le Bras, BX Gao, C Leterrier, C Leterrier, C Nakada, CG Dotti, D Sanchez-Ponce, D Zhou, DL Sherman, E Kordeli, Erika Bullier, François Couraud, G Lemaillet, H Kuba, H Wichterle, JJ Devaux, JJ Garrido, JM Sobotzik, JM Wilson, JS Dasen, KJ Bender, KL Hedstrom, KL Hedstrom, LE Wentworth, M Bouzidi, M Komada, M Takahashi, Marc Davenne, Masayuki Komada, MH Kole, MN Rasband, MR Galiano, MS Grubb, N Alessandri-Haber, N Matsuda, N Ulfig, Pascal Legendre, Peter J. Brophy, S Arber, S Berghs, S Lacas-Gervais, S Pun, S Tait, SM Jenkins, TA Maniar, V Bernard, Y Dzhashiashvili, Y Ogawa, Y Uemoto, Z Pan   +60 more
core   +3 more sources