Results 51 to 60 of about 56,490 (282)

MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon

Cell Reports, 2019
Summary: The motor protein kinesin-1 plays an important role in polarized sorting of transport vesicles to the axon. However, the mechanism by which the axonal entry of kinesin-1-dependent cargo transport is regulated remains unclear.
Xingxiu Pan, Yujie Cao, Riccardo Stucchi, Peter Jan Hooikaas, Sybren Portegies, Lena Will, Maud Martin, Anna Akhmanova, Martin Harterink, Casper C. Hoogenraad   +9 more
doaj   +1 more source

Neurofascin and Kv7.3 are delivered to somatic and axon terminal surface membranes en route to the axon initial segment

eLife, 2020
Ion channel complexes promote action potential initiation at the mammalian axon initial segment (AIS), and modulation of AIS size by recruitment or loss of proteins can influence neuron excitability.
Aniket Ghosh, Elise LV Malavasi, Diane L Sherman, Peter J Brophy   +3 more
doaj   +1 more source

Fast sodium channel gating supports localized and efficient axonal action potential initiation [PDF]

, 2010
Action potentials (APs) are initiated in the proximal axon of most neurons. In myelinated axons, a 50-times higher sodium channel density in the initial segment compared to the soma may account for this phenomenon.
Bischofberger, Josef, Schmidt-Hieber, Christoph   +1 more
core   +2 more sources

Feedback-Driven Assembly of the Axon Initial Segment [PDF]

Neuron, 2019
The axon initial segment (AIS) is a unique neuronal compartment that plays a crucial role in the generation of action potential and neuronal polarity. The assembly of the AIS requires membrane, scaffolding, and cytoskeletal proteins, including Ankyrin-G and TRIM46. How these components cooperate in AIS formation is currently poorly understood. Here, we
Fréal, Amélie, Rai, Dipti, Tas, Roderick P, Pan, Xingxiu, Katrukha, Eugene A, van de Willige, Dieudonnée, Stucchi, Riccardo, Aher, Amol, Yang, Chao, Altelaar, A F Maarten, Vocking, Karin, Post, Jan Andries, Harterink, Martin, Kapitein, Lukas C, Akhmanova, Anna, Hoogenraad, Casper C   +15 more
openaire   +7 more sources

Nanodiamonds-induced effects on neuronal firing of mouse hippocampal microcircuits [PDF]

, 2018
Fluorescent nanodiamonds (FND) are carbon-based nanomaterials that can efficiently incorporate optically active photoluminescent centers such as the nitrogen-vacancy complex, thus making them promising candidates as optical biolabels and drug-delivery ...
Battiato, A., Calorio, C., Carabelli, V., Carbone, E., Forneris, J., Gai, M., Gavello, D., Genovese, M., Guarina, L., Marcantoni, A., Moreva, E., Olivero, P., Picollo, F., Tchernij, S. Ditalia, Traina, P.   +14 more
core   +4 more sources

Regulation of plasma membrane expansion during axon formation [PDF]

, 2018
Here, will review current evidence regarding the signaling pathways and mechanisms underlying membrane addition at sites of active growth during axon formation.Fil: Quiroga, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas.
Bisbal, Mariano, Caceres, Alfredo Oscar, Quiroga, Santiago   +2 more
core   +1 more source

Consciousness and spintronic coherence in microtubules

Communicative & Integrative Biology
Microtubules are nanoscale spintronic oscillators with memristive properties. Spintronic and memristive effects, together with some unique conditions found in the axon initial segment (AIS), allow quantum coherence to emerge spontaneously in a population
Majid Beshkar
doaj   +1 more source

Cerebellar Golgi cell models predict dendritic processing and mechanisms of synaptic plasticity.

PLoS Computational Biology, 2020
The Golgi cells are the main inhibitory interneurons of the cerebellar granular layer. Although recent works have highlighted the complexity of their dendritic organization and synaptic inputs, the mechanisms through which these neurons integrate complex
Stefano Masoli, Alessandra Ottaviani, Stefano Casali, Egidio D'Angelo   +3 more
doaj   +1 more source

Spikelets in Pyramidal Neurons: Action Potentials Initiated in the Axon Initial Segment That Do Not Activate the Soma. [PDF]

PLoS Computational Biology, 2017
Spikelets are small spike-like depolarizations that can be measured in somatic intracellular recordings. Their origin in pyramidal neurons remains controversial.
Martina Michalikova, Michiel W H Remme, Richard Kempter   +2 more
doaj   +1 more source

Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study

EBioMedicine, 2021
Background: tinnitus is a heterogeneous condition associated with audiological and/or mental disorders. Chronic, severe tinnitus is reported in 1% of the population and it shows a relevant heritability, according to twins, adoptees and familial ...
Sana Amanat, Alvaro Gallego-Martinez, Joseph Sollini, Patricia Perez-Carpena, Juan M. Espinosa-Sanchez, Ismael Aran, Andres Soto-Varela, Angel Batuecas‐Caletrio, Barbara Canlon, Patrick May, Christopher R. Cederroth, Jose A. Lopez-Escamez   +11 more
doaj   +1 more source