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Biological Reviews, 1996
Axons damaged in a peripheral nerve are often able to regenerate from the site of injury along the degenerate distal segment of the nerve to reform functional synapses. Schwann cells play a central role in this process. However, in the adult mammalian central nervous system, from which Schwann cells are absent, axonal regeneration does not progress to ...
J E, Brecknell, J W, Fawcett
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Axons damaged in a peripheral nerve are often able to regenerate from the site of injury along the degenerate distal segment of the nerve to reform functional synapses. Schwann cells play a central role in this process. However, in the adult mammalian central nervous system, from which Schwann cells are absent, axonal regeneration does not progress to ...
J E, Brecknell, J W, Fawcett
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Neurological Research, 2008
To increase awareness of the advancements in nerve regeneration.Review of the literature regarding inhibitors of nerve outgrowth and presentation of potential agents that reverse the inhibition, thereby promoting nerve regeneration.The injured adult central nervous system (CNS) inhibits axon outgrowth, thereby limiting recovery from traumatic injury ...
Lynda J-S, Yang, Ronald L, Schnaar
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To increase awareness of the advancements in nerve regeneration.Review of the literature regarding inhibitors of nerve outgrowth and presentation of potential agents that reverse the inhibition, thereby promoting nerve regeneration.The injured adult central nervous system (CNS) inhibits axon outgrowth, thereby limiting recovery from traumatic injury ...
Lynda J-S, Yang, Ronald L, Schnaar
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Intrinsic heterogeneity in axon regeneration
Biochemical Society Transactions, 2022The nervous system is composed of a variety of neurons and glial cells with different morphology and functions. In the mammalian peripheral nervous system (PNS) or the lower vertebrate central nervous system (CNS), most neurons can regenerate extensively after axotomy, while the neurons in the mammalian CNS possess only limited regenerative ability ...
Xiu-Qing Fu +4 more
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Inflammation and axon regeneration
Current Opinion in Neurology, 2011The inflammatory response that accompanies neural injury involves multiple cell types and effector molecules with both positive and negative effects. Inflammation is essential for normal regeneration in the peripheral nervous system, and here we review evidence that augmenting inflammation can enhance regeneration in areas of the central nervous system
Larry I, Benowitz, Phillip G, Popovich
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Inflammation and axonal regeneration
Journal of Neurology, 1994Inflammatory cells and their products contribute to neuronal survival and axonal regeneration after injury. Following sciatic nerve transection in rats, macrophages accumulate in the corresponding dorsal root ganglion, potentially supplying neurotrophic support to nerve cell bodies, and enhancing axonal regeneration.
P M, Richardson, X, Lu
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Molecular Neurobiology
This review explores the molecular and genetic underpinnings of axonal regeneration and functional recovery post-nerve injury, emphasizing its significance in reversing neurological deficits. It presents a systematic exploration of the roles of various genes in axonal regrowth across peripheral and central nerve injuries. Initially, it highlights genes
Wenshuang Wu +7 more
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This review explores the molecular and genetic underpinnings of axonal regeneration and functional recovery post-nerve injury, emphasizing its significance in reversing neurological deficits. It presents a systematic exploration of the roles of various genes in axonal regrowth across peripheral and central nerve injuries. Initially, it highlights genes
Wenshuang Wu +7 more
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PTEN/mTOR and axon regeneration
Experimental Neurology, 2010How axon regeneration is controlled in both PNS and CNS remains elusive. Mechanistic studies of axon growth during development and axon regeneration after injury reveal the PTEN dependent molecular mechanism as a commonality. This pathway could impact the processes occurring in the neuronal soma, such as mTOR-regulated protein translation, and in the ...
Park, Kevin K. +4 more
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Axonal Regeneration Through Autologous Grafts: Does the Axonal Load Influence Regeneration?
Journal of Surgical Research, 2022Two-stage free functional muscle transfers for long-standing facial palsy can yield unpredictable results. Earlier studies have demonstrated incomplete regeneration across neurorrhaphies in native nerve and higher donor axonal counts correlating with improved outcomes but axonal count in nerve grafts have not been as thoroughly reviewed. To investigate
Jonathan I. Leckenby +4 more
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