Results 301 to 310 of about 38,776 (318)

Nogo and axon regeneration

Current Opinion in Neurobiology, 2004
Nogo-A is one of several neurite growth inhibitory components present in oligodendrocytes and CNS myelin membranes. Nogo has a crucial role in restricting axonal regeneration and compensatory fibre growth in the injured adult mammalian CNS. Recent studies have shown that in vivo applications of Nogo neutralizing antibodies, peptides blocking the Nogo ...
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Regeneration of axons in tributary nerves

Brain Research, 1984
The present study tests 2 hypotheses: (1) that the numbers of axons that regenerate into a tributary nerve are in part dependent on the type of lesion used to transect the axons in the parent nerve; and (2) that the numbers of axons that regenerate will be different in different tributary nerves.
Chung Bii Jenq, Richard E. Coggeshall
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Retrograde signaling in axonal regeneration

Experimental Neurology, 2010
Neuronal regeneration in the peripheral nervous system requires mobilization of intrinsic neurite outgrowth mechanisms. This process depends on retrograde signaling between lesion site and soma to provide accurate and timely information on the nature and extent of axonal damage, and to elicit an appropriate cell body response.
Ida Rishal, Mike Fainzilber
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Genes in Axonal Regeneration

Molecular Neurobiology
This review explores the molecular and genetic underpinnings of axonal regeneration and functional recovery post-nerve injury, emphasizing its significance in reversing neurological deficits. It presents a systematic exploration of the roles of various genes in axonal regrowth across peripheral and central nerve injuries. Initially, it highlights genes
Wenshuang Wu, Jing Zhang, Yu Chen, Qianqian Chen, Qianyan Liu, Fuchao Zhang, Shiying Li, Xinghui Wang   +7 more
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Mechanisms of Axon Regeneration

2007
The inability of injured central neurons to regenerate their axons and rebuild their functional connections leads consequently to permanent loss of function following injury of central nervous system (CNS). The consequences of injury are not just a break in communication between neurons but also a cascade of events leading to neuronal degeneration and ...
Zhigang He, Jan M. Schwab
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Axonal Regeneration in Nematodes

Science Signaling, 2009
Axon regeneration in adult nematode worms has distinct signals that are independent of earlier developmental programs.
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Treatment synergy in axon regeneration

Nature Neuroscience, 2016
Injured mouse retinal ganglion cells, upon a combination of treatments, can regrow their axons along the entire optic pathway and re-establish connections with their correct brain targets. This can partially restore function.
Botond Roska, Botond Roska, Jacek Krol
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Building bridges to regenerate axons

Science, 2016
A secreted factor stimulates glia to mend spinal cord ...
Philip R. Williams, Zhigang He
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Topological aspects of axonal regeneration

Medical Hypotheses, 2003
The fibers making up any sensory system in the spinal cord come from the same cells as do the fibers in peripheral nerves yet severed nerve fibers in the adult spinal cord do not regenerate but damaged peripheral nerves - those in the extremities - do heal themselves.
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Rho Signaling and Axon Regeneration

2012
Several major advances in our understanding of axon regeneration and functional repair in the central nervous system (CNS) together with new insights about molecular signaling pathways have led to development of viable drug candidates to treat spinal cord injury. In this review, we focus on Rho, an intracellular small GTPase that is part of a family of
Alyson E. Fournier, Gino B. Ferraro, Lisa McKerracher   +2 more
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