Results 261 to 270 of about 271,555 (310)
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Biological Reviews, 1996
Axons damaged in a peripheral nerve are often able to regenerate from the site of injury along the degenerate distal segment of the nerve to reform functional synapses. Schwann cells play a central role in this process. However, in the adult mammalian central nervous system, from which Schwann cells are absent, axonal regeneration does not progress to ...
J E, Brecknell, J W, Fawcett
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Axons damaged in a peripheral nerve are often able to regenerate from the site of injury along the degenerate distal segment of the nerve to reform functional synapses. Schwann cells play a central role in this process. However, in the adult mammalian central nervous system, from which Schwann cells are absent, axonal regeneration does not progress to ...
J E, Brecknell, J W, Fawcett
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Science Signaling, 2023
Demyelination by microglia reduces the likelihood of axonal degeneration in a model of cytotoxic T cell–driven myelin perturbation.
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Demyelination by microglia reduces the likelihood of axonal degeneration in a model of cytotoxic T cell–driven myelin perturbation.
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The optic nerve head is the site of axonal transport disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucoma [PDF]
Acta Neuropathologica, 2011 The neurodegenerative disease glaucoma is characterised by the progressive death of retinal ganglion cells (RGCs) and structural damage to the optic nerve (ON).
Andreas Ebneter +2 more
exaly +3 more sources
Current Opinion in Neurobiology, 1998
For more than a century, neuroscientists have gained insight into brain function by examining its complex patterns of connectivity. To achieve this, a wide variety of axon-tracing techniques have been employed to chart the projections of neurons. New, experimentally flexible, reporter-based tracers, many of which are fusion proteins designed to target ...
C A, Callahan, S, Yoshikawa, J B, Thomas
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For more than a century, neuroscientists have gained insight into brain function by examining its complex patterns of connectivity. To achieve this, a wide variety of axon-tracing techniques have been employed to chart the projections of neurons. New, experimentally flexible, reporter-based tracers, many of which are fusion proteins designed to target ...
C A, Callahan, S, Yoshikawa, J B, Thomas
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2013
The Neuroaxonal Dystrophies (NADs) are a group of clinically and genetically heterogeneous neurodegenerative conditions. These disorders show the unique pathological feature of neuroaxonal dystrophy (NAD): axonal swelling (spheroids) localized throughout the central nervous and peripheral nervous systems.
Nardo, Nardocci, Giovanna, Zorzi
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The Neuroaxonal Dystrophies (NADs) are a group of clinically and genetically heterogeneous neurodegenerative conditions. These disorders show the unique pathological feature of neuroaxonal dystrophy (NAD): axonal swelling (spheroids) localized throughout the central nervous and peripheral nervous systems.
Nardo, Nardocci, Giovanna, Zorzi
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2007
The formidable task of accurately establishing the connections of the central nervous system appears to be conserved throughout phylogeny as most of the key molecules that mediate the formation of the nervous system are found in organisms separated by millions of years of evolutionary distance.
Strochlic, L. +3 more
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The formidable task of accurately establishing the connections of the central nervous system appears to be conserved throughout phylogeny as most of the key molecules that mediate the formation of the nervous system are found in organisms separated by millions of years of evolutionary distance.
Strochlic, L. +3 more
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Abnormalities of the axonal cytoskeleton in giant axonal neuropathy
Journal of Neurocytology, 1988Intermediate filaments accumulate abnormally in a variety of cell types in individuals with human inherited giant axonal neuropathy (GAN). A characteristic feature of this disorder is the occurrence of focal axonal enlargements filled with accumulations of neurofilaments.
M, Donaghy +3 more
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2009
Axon pathfinding is an important process in the development of the nervous system. Models have been developed which describe or attempt to explain various aspects of axon pathfinding, such as axon extension, axon turning, axon guidance, interactions between axons, retinotectal mapping, and the way in which guidance cue patterns are generated in the ...
Mortimer, D., Goodhill, G. J.
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Axon pathfinding is an important process in the development of the nervous system. Models have been developed which describe or attempt to explain various aspects of axon pathfinding, such as axon extension, axon turning, axon guidance, interactions between axons, retinotectal mapping, and the way in which guidance cue patterns are generated in the ...
Mortimer, D., Goodhill, G. J.
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Persistence of Axonal Transport in Isolated Axons of the Mouse
European Journal of Neuroscience, 1993AbstractWe have examined the hypothesis, for the case of mouse axons, that isolating an axon from its cell body will lead to a rapid failure of fast axonal transport as anterogradely moving organelles vacate the axon in a proximo‐distal direction, and retrogradely moving organelles vacate it in the opposite direction.
R S, Smith, M A, Bisby
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Fast Axonal Transport in Squid Giant Axon
Science, 1982Video-enhanced contrast-differential interference contrast microscopy has revealed new features of axonal transport in the giant axon of the squid, where no movement had been detected previously by conventional microscopy. The newly discovered dominant feature is vast numbers of "submicroscopic" particles, probably 30- to 50-nanometer vesicles and ...
R D, Allen +4 more
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