Results 31 to 40 of about 122,498 (328)

Axonal Transport: A Constrained System [PDF]

Journal of Neurology and Neuromedicine, 2017
Long-distance intracellular axonal transport is predominantly microtubule-based, and its impairment is linked to neurodegeneration. Here we review recent theoretical and experimental evidence that suggest that near the axon boundaries (walls), the effective viscosity can become large enough to impede cargo transport in small (but not large) caliber ...
Yu, Clare C, Reddy, Babu JN, Wortman, Juliana C, Gross, Steven P   +3 more
openaire   +5 more sources

Impaired axonal transport in motor neurons correlates with clinical prion disease. [PDF]

PLoS Pathogens, 2009
Prion diseases are fatal neurodegenerative disorders causing motor dysfunctions, dementia and neuropathological changes such as spongiosis, astroglyosis and neuronal loss. The chain of events leading to the clinical disease and the role of distinct brain
Vladimir Ermolayev, Toni Cathomen, Julia Merk, Mike Friedrich, Wolfgang Härtig, Gregory S Harms, Michael A Klein, Eckhard Flechsig   +7 more
doaj   +1 more source

A Gate Keeper for Axonal Transport [PDF]

Cell, 2009
The axon and dendritic arbor of neurons require different sets of membrane proteins to carry out their functions. In this issue, Song et al. (2009) describe how a cytoplasmic diffusion barrier in the axon initial segment of rat hippocampal neurons ensures that only axonal (and not dendritic) membrane proteins enter the axon.
Lily Yeh Jan, Shaohua Xiao
openaire   +3 more sources

Decreased anterograde transport coupled with sustained retrograde transport contributes to reduced axonal mitochondrial density in tauopathy neurons

Frontiers in Molecular Neuroscience, 2022
Mitochondria are essential organelle required for neuronal homeostasis. Mitochondria supply ATP and buffer calcium at synaptic terminals. However, the complex structural geometry of neurons poses a unique challenge in transporting mitochondria to ...
Anusruti Sabui, Mitali Biswas, Pramod Rajaram Somvanshi, Preethi Kandagiri, Madhavi Gorla, Fareed Mohammed, Prasad Tammineni   +6 more
doaj   +1 more source

SNTF immunostaining reveals previously undetected axonal pathology in traumatic brain injury [PDF]

, 2015
Diffuse axonal injury (DAI) is a common feature of severe traumatic brain injury (TBI) and may also be a predominant pathology in mild TBI or “concussion”.
Cullen, D. Kacy, Johnson, Victoria E., Siman, Robert, Smith, Douglas H., Stewart, William, Weber, Maura T.   +5 more
core   +1 more source

Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer’s disease and regulates axonal transport and processing of the amyloid precursor protein

Acta Neuropathologica Communications, 2019
Damage to axonal transport is an early pathogenic event in Alzheimer’s disease. The amyloid precursor protein (APP) is a key axonal transport cargo since disruption to APP transport promotes amyloidogenic processing of APP.
Gábor M. Mórotz, Elizabeth B. Glennon, Jenny Greig, Dawn H. W. Lau, Nishita Bhembre, Francesca Mattedi, Nadine Muschalik, Wendy Noble, Alessio Vagnoni, Christopher C. J. Miller   +9 more
doaj   +1 more source

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations [PDF]

, 2014
​Leucine-rich repeat kinase 2 (​LRRK2) mutations are the most common genetic cause of Parkinson’s disease. ​LRRK2 is a multifunctional protein affecting many cellular processes and has been described to bind microtubules.
A Weihofen, A Zimprich, AB West, AB West, AR Saha, BM Law, C d’Ydewalle, C d’Ydewalle, C Hubbert, C Kim, C Paisan-Ruiz, C Simoes-Pires, CH Lin, CM Southwood, D Cartelli, D MacLeod, E Greggio, E Hu, ED Plowey, EM Valente, F Gillardon, F Gillardon, G Dietzl, G Morfini, GM Morotz, I Taes, J Alegre-Abarrategui, J Simon-Sanchez, JC Greene, JM Taymans, JP Dompierre, JS Akella, JS Kim-Han, KJ De Vos, KJ De Vos, KJ De Vos, KJ De Vos, KV Butler, L Guo, L Parisiadou, LR Kett, M Caesar, M Jaleel, M Meulener, ML Kuznicki, MR Cookson, N Dzamko, N Govindarajan, N Kalebic, NA Reed, PA Lewis, Q Cai, S Ackerley, S Chen, S Liu, SB Lee, SJ Haggarty, T Kitada, T Shida, TF Outeiro, V Daniels, W Satake, WP Gilks, X Li, X Wang, Y Chu, Y Imai, Z Liu   +67 more
core   +2 more sources

The evolution of the axonal transport toolkit [PDF]

Traffic, 2019
AbstractNeurons are highly polarized cells that critically depend on long‐range, bidirectional transport between the cell body and synapse for their function. This continual and highly coordinated trafficking process, which takes place via the axon, has fascinated researchers since the early 20th century.
James N. Sleigh, James N. Sleigh, David Villarroel-Campos, Edoardo Moretto, Sandy Richter, Elena R. Rhymes, Giampietro Schiavo, Giampietro Schiavo, Oscar M. Lazo, Oscar M. Lazo, Sunaina Surana, Andrew P. Tosolini   +11 more
openaire   +3 more sources

Axonal transport defects are a common phenotype in Drosophila models of ALS [PDF]

, 2016
Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motor neurons resulting in a catastrophic loss of motor function. Current therapies are severely limited owing to a poor mechanistic understanding of the pathobiology ...
Alexander J. Whitworth, Honda, Katie R. Baldwin, Victoria L. Hewitt, Vinay K. Godena, Zinszner   +5 more
core   +1 more source

Diffuse axonal injury and oxidative stress: A comprehensive review [PDF]

, 2017
Traumatic brain injury (TBI) is one of the worldâ\u80\u99s leading causes of morbidity and mortality among young individuals. TBI applies powerful rotational and translational forces to the brain parenchyma, which results in a traumatic diffuse axonal ...
Cerretani, Daniela, Fiaschi, Anna Ida, Fineschi, Vittorio, Fraschetti, Flavia, Frati, Alessandro, Frati, Paola, Gatto, Vittorio, La Russa, Raffaele, Pesce, Alessandro, Pinchi, Enrica, Santurro, Alessandro   +10 more
core   +4 more sources