Results 31 to 40 of about 2,606,125 (326)
Cyclophilin D deficiency rescues axonal mitochondrial transport in Alzheimer's neurons. [PDF]
PLoS ONE, 2013 Normal axonal mitochondrial transport and function is essential for the maintenance of synaptic function. Abnormal mitochondrial motility and mitochondrial dysfunction within axons are critical for amyloid β (Aβ)-induced synaptic stress and the loss of ...
Lan Guo +6 more
doaj +1 more source
Axonal Transport and Mitochondrial Function in Neurons
Frontiers in Cellular Neuroscience, 2019 The complex and elaborate architecture of a neuron poses a great challenge to the cellular machinery which localizes proteins and organelles, such as mitochondria, to necessary locations.
Amrita Mandal, Catherine M. Drerup
semanticscholar +1 more source
Axonal Transport Enables Neuron-to-Neuron Propagation of Human Coronavirus OC43
Journal of Virology, 2018 Coronaviruses may invade the CNS, disseminate, and participate in the induction of neurological diseases. Their neuropathogenicity is being increasingly recognized in humans, and the presence and persistence of human coronaviruses (HCoV) in human brains ...
M. Dubé +5 more
semanticscholar +1 more source
CRMP/UNC-33 organizes microtubule bundles for KIF5-mediated mitochondrial distribution to axon.
PLoS Genetics, 2021 Neurons are highly specialized cells with polarized cellular processes and subcellular domains. As vital organelles for neuronal functions, mitochondria are distributed by microtubule-based transport systems.
Ying-Chun Chen +3 more
doaj +1 more source
Impaired axonal transport in motor neurons correlates with clinical prion disease. [PDF]
PLoS Pathogens, 2009 Prion diseases are fatal neurodegenerative disorders causing motor dysfunctions, dementia and neuropathological changes such as spongiosis, astroglyosis and neuronal loss. The chain of events leading to the clinical disease and the role of distinct brain
Vladimir Ermolayev +7 more
doaj +1 more source
Neurobiology of Disease, 2017 Many neurodegenerative diseases are characterized by deficiencies in neuronal axonal transport, a process in which cellular cargo is shuttled with the aid of molecular motors from the cell body to axonal termini and back along microtubules (MTs).
Kurt R. Brunden +4 more
doaj +1 more source
Nature NeuroscienceIn neurons, RNA granules are transported along the axon for local translation away from the soma. Recent studies indicate that some of this transport involves hitchhiking of RNA granules on lysosome-related vesicles.
Raffaella De Pace +9 more
semanticscholar +1 more source
HDAC6 inhibition reverses axonal transport defects in motor neurons derived from FUS-ALS patients
Nature Communications, 2017 Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder due to selective loss of motor neurons (MNs). Mutations in the fused in sarcoma (FUS) gene can cause both juvenile and late onset ALS.
Wenting Guo +25 more
semanticscholar +1 more source
Profiling Axonal mRNA Transport [PDF]
, 2011 The importance of mRNA localization and localized protein synthesis to spatially modulate protein levels in distinct subcellular domains has increasingly been recognized in recent years. Axonal and dendritic processes of neurons represent separate functional domains of the cell that have shown the capacity to autonomously respond to extracellular ...
Dianna E, Willis, Jeffery L, Twiss
openaire +2 more sources
Acta Neuropathologica Communications, 2019 Damage to axonal transport is an early pathogenic event in Alzheimer’s disease. The amyloid precursor protein (APP) is a key axonal transport cargo since disruption to APP transport promotes amyloidogenic processing of APP.
Gábor M. Mórotz +9 more
doaj +1 more source