Results 41 to 50 of about 2,606,125 (326)

Decreased anterograde transport coupled with sustained retrograde transport contributes to reduced axonal mitochondrial density in tauopathy neurons

Frontiers in Molecular Neuroscience, 2022
Mitochondria are essential organelle required for neuronal homeostasis. Mitochondria supply ATP and buffer calcium at synaptic terminals. However, the complex structural geometry of neurons poses a unique challenge in transporting mitochondria to ...
Anusruti Sabui, Mitali Biswas, Pramod Rajaram Somvanshi, Preethi Kandagiri, Madhavi Gorla, Fareed Mohammed, Prasad Tammineni   +6 more
doaj   +1 more source

C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility

Science Advances, 2019
Arginine-rich dipeptide repeats associated with ALS and FTD inhibit machinery for microtubule-based axonal cargo transport. A hexanucleotide repeat expansion in the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and ...
L. Fumagalli, Florence L. Young, S. Boeynaems, Mathias De Decker, A. Mehta, A. Swijsen, Raheem Fazal, Wenting Guo, M. Moisse, Jimmy Beckers, L. Dedeene, B. Selvaraj, T. Vandoorne, Vanesa Madan, M. van Blitterswijk, D. Raitcheva, Alexander McCampbell, K. Poesen, A. Gitler, Philipp Koch, P. Berghe, D. Thal, C. Verfaillie, S. Chandran, L. Van Den Bosch, S. Bullock, P. van Damme   +26 more
semanticscholar   +1 more source

Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement

Neurobiology of Disease, 2019
Mitochondria are crucial organelles for neurophysiology and brain mitochondrial defects constitute a characteristic of Alzheimer's disease (AD). Impaired axonal mitochondrial traffic, especially the anterograde axonal mitochondrial transport is a ...
Qi Wang, Jing Tian, Hao Chen, Heng Du, Lan Guo   +4 more
doaj   +1 more source

ATAT1-enriched vesicles promote microtubule acetylation via axonal transport

Science Advances, 2019
The axonal transport of vesicles promotes microtubule acetylation across species. Microtubules are polymerized dimers of α- and β-tubulin that underlie a broad range of cellular activities.
Aviel Even, G. Morelli, C. Scaramuzzino, Ivan Gladwyn-Ng, Romain Le Bail, Michal Shilian, Stephen Freeman, M. Magiera, A. S. Jijumon, B. Malgrange, B. Brône, Paula Dietrich, I. Dragatsis, C. Janke, F. Saudou, M. Weil, L. Nguyen   +16 more
semanticscholar   +1 more source

The evolution of the axonal transport toolkit

Traffic : the International Journal of Intracellular Transport, 2019
Neurons are highly polarized cells that critically depend on long‐range, bidirectional transport between the cell body and synapse for their function.
Sunaina Surana, David Villarroel-Campos, O. M. Lazo, E. Moretto, A. Tosolini, Elena R. Rhymes, Sandy Richter, J. Sleigh, G. Schiavo   +8 more
semanticscholar   +1 more source

LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer’s disease brains

Acta Neuropathologica Communications, 2019
Cyclin dependent kinase-5 (cdk5)/p35 is a neuronal kinase that regulates key axonal and synaptic functions but the mechanisms by which it is transported to these locations are unknown. Lemur tyrosine kinase-2 (LMTK2) is a binding partner for p35 and here
Gábor M. Mórotz, Elizabeth B. Glennon, Patricia Gomez-Suaga, Dawn H. W. Lau, Eleanor D. Robinson, Éva Sedlák, Alessio Vagnoni, Wendy Noble, Christopher C. J. Miller   +8 more
doaj   +1 more source

Unraveling axonal mechanisms of traumatic brain injury

Acta Neuropathologica Communications, 2022
Axonal swellings (AS) are one of the neuropathological hallmark of axonal injury in several disorders from trauma to neurodegeneration. Current evidence proposes a role of perturbed Ca2+ homeostasis in AS formation, involving impaired axonal transport ...
Victorio M. Pozo Devoto, Valentina Lacovich, Monica Feole, Pratiksha Bhat, Jaroslav Chovan, Maria Čarna, Isaac G. Onyango, Neda Dragišić, Martina Sűsserová, Martin E. Barrios-Llerena, Gorazd B. Stokin   +10 more
doaj   +1 more source

Internalization, axonal transport and release of fibrillar forms of alpha-synuclein.

Neurobiology of Disease, 2018
Intra-neuronal protein aggregates made of fibrillar alpha-synuclein (α-syn) are the hallmark of Parkinson's disease (PD). With time, these aggregates spread through the brain following axonal projections.
Gregor Bieri, A. Gitler, M. Brahic
semanticscholar   +1 more source

The axonal transport of mitochondria [PDF]

Journal of Cell Science, 2005
Organelle transport is vital for the development and maintenance of axons, in which the distances between sites of organelle biogenesis, function, and recycling or degradation can be vast. Movement of mitochondria in axons can serve as a general model for how all organelles move: mitochondria are easy to identify, they move along both microtubule and ...
Peter J, Hollenbeck, William M, Saxton
openaire   +4 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source