Results 101 to 110 of about 224,860 (308)

Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse [PDF]

, 2012
Mice overexpressing proteolipid protein (PLP) develop a leukodystrophy-like disease involving cytotoxic, CD8+ T-lymphocytes. Here we show that these cytotoxic T-lymphocytes perturb retrograde axonal transport.
Groh Janos, Dennis Klein, Spahn, Irene, Klein Dennis, Huber, M., Spahn, I., Ip, Chi Wang, Nave, Klaus-Armin, Diem Ricarda, Groh, J., Ip Chi Wang, Huber, Marianne, Sarah K. Williams, Rudolf Martini, Martini Rudolf, Kroner, A., Janos Groh, Ip, C., Williams, S., Edgar, Julia M., Kroner Antje, Huber Marianne, Ip, C.W., Martini, Rudolf, Nave Klaus-Armin, Martini, R., Antje Kroner, Chi Wang Ip, Diem, Ricarda, Edgar Julia M., Kroner, Antje, Julia M Edgar, Williams, Sarah K., Nave, K., Marianne Huber, Julia M. Edgar, Spahn Irene, Diem, R., Klaus-Armin Nave, Ricarda Diem, Sarah K Williams, Groh, Janos, Klein, Dennis, Klein, D., Edgar, J., Edgar, J.M., Williams Sarah K., Irene Spahn   +47 more
core   +1 more source

Nose-to-brain translocation of inhaled ultrafine elongated particles: facts and mysteries

Frontiers in Toxicology
In this study, we report that inhaled nanosized elongated mineral particles (EMPs) reach the human central nervous system (CNS) via two neuronal pathways, cranial nerve I (olfactorius) and cranial nerve V (trigeminus), from deposits on the nasal mucosa ...
U. M. Graham, J. M. Pinto, J. Weuve, A. K. Dozier, R. Rogers, S. Nag, S. Nag, J. Schneider, J. Schneider, J. D. Kaufman, D. A. Bennett, D. A. Bennett, G. Oberdörster, G. Oberdörster   +13 more
doaj   +1 more source

Severity of Demyelinating and Axonal Neuropathy Mouse Models Is Modified by Genes Affecting Structure and Function of Peripheral Nodes

Cell Reports, 2017
Charcot-Marie-Tooth (CMT) disease is a clinically and genetically heterogeneous group of inherited polyneuropathies. Mutations in 80 genetic loci can cause forms of CMT, resulting in demyelination and axonal dysfunction.
Kathryn H. Morelli, Kevin L. Seburn, David G. Schroeder, Emily L. Spaulding, Loiuse A. Dionne, Gregory A. Cox, Robert W. Burgess   +6 more
doaj   +1 more source

Thermoresponsive Soft and Self‐Anchoring Cuff Electrode for Chronic Peripheral Interfaces

Advanced Functional Materials, EarlyView.
A novel thermoresponsive, soft and self‐anchoring (TSSA) cuff electrode utilizing shape memory polymers achieves autonomous, sutureless peripheral nerve fixation. Driven by thermally induced pre‐strain and tissue adhesion, the device self‐closes and softens at body temperature, successfully minimizing mechanical mismatch. This adaptive platform ensures
Seungjun Lee, Byungwook Park, Jonghee Eun, Sohee Kim, Namsun Chou   +4 more
wiley   +1 more source

Effects of cilostazol on the progression and regression of symptomatic intracranial artery stenosis: it reduces the risk of ischemic stroke

Neural Regeneration Research, 2015
OBJECTIVE: To assess the efficacy and safety of cilostazol on the progression and regression of symptomatic intracranial artery stenosis. DATA RETRIVAL: We searched the main databases for eligible trials including Medline (from 1966 to June 2014), Embase
Wenhui Zhang, Fangfang Cai, Zhongmin Wen
doaj   +1 more source

Emerging Post‐CMOS Hardware Neurons for Brain‐Inspired Computing: Devices, Circuits, and System Integration

Advanced Functional Materials, EarlyView.
The physical realization of artificial neurons is a critical challenge for energy‐efficient neuromorphic computing. This review presents a comprehensive analysis of the evolution of artificial neuron implementations from conventional CMOS to emerging post‐CMOS technologies.
Kannan Udaya Mohanan, Hocheon Yoo, Benoît H. Lessard, Ioannis Kymissis, Chang‐Hyun Kim   +4 more
wiley   +1 more source

Optic nerve hypoplasia in the fetal alcohol syndrome:a mouse model [PDF]

, 1995
Optic nerve hypoplasia is commonly observed in children affected by the fetal alcohol syndrome, and is believed to contribute to their poor visual acuity.
Dhillon, Baljean, Parson, S H, Findlater, G S, Kaufman, M H   +3 more
core  

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Studying Axon-Astrocyte Functional Interactions by 3D Two-Photon Ca2+ Imaging: A Practical Guide to Experiments and “Big Data” Analysis

Frontiers in Cellular Neuroscience, 2018
Recent advances in fast volumetric imaging have enabled rapid generation of large amounts of multi-dimensional functional data. While many computer frameworks exist for data storage and analysis of the multi-gigabyte Ca2+ imaging experiments in neurons ...
Iaroslav Savtchouk, Giovanni Carriero, Andrea Volterra   +2 more
doaj   +1 more source

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

Advanced Functional Materials, EarlyView.
This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu, Yumin Wu, Xiang Gao, Tianlu Wang, Wanting Jia, Xueying Mei, Huanzhong Ji, Zongxi Wu, Yujie Liang, Xiang Li, Kan Li, Jingyuan Li, Guangsen Zheng, Guiqing Liao, Siyong Gao   +14 more
wiley   +1 more source