Results 271 to 280 of about 210,849 (318)

Axonal dystrophies

2013
The Neuroaxonal Dystrophies (NADs) are a group of clinically and genetically heterogeneous neurodegenerative conditions. These disorders show the unique pathological feature of neuroaxonal dystrophy (NAD): axonal swelling (spheroids) localized throughout the central nervous and peripheral nervous systems.
Nardo, Nardocci, Giovanna, Zorzi
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Persistence of Axonal Transport in Isolated Axons of the Mouse

European Journal of Neuroscience, 1993
AbstractWe have examined the hypothesis, for the case of mouse axons, that isolating an axon from its cell body will lead to a rapid failure of fast axonal transport as anterogradely moving organelles vacate the axon in a proximo‐distal direction, and retrogradely moving organelles vacate it in the opposite direction.
R S, Smith, M A, Bisby
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Axonal transport of lipid in goldfish optic axons

Neurochemical Research, 1978
After injection of labeled glycerol, choline, or serine into the eye of goldfish, labeled lipids were axonally transported along the optic nerve to the optic tectum. Although the different precursors were presumably incorporated into somewhat different lipid populations, all three were approximately equally effective in labeling the lipids transported ...
J R, Currie, B, Grafstein, M H, Whitnall, R, Alpert   +3 more
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Axon Pathfinding

2007
The formidable task of accurately establishing the connections of the central nervous system appears to be conserved throughout phylogeny as most of the key molecules that mediate the formation of the nervous system are found in organisms separated by millions of years of evolutionary distance.
Strochlic, L., Weinl, C., Piper, M., Holt, C. E.   +3 more
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Abnormalities of the axonal cytoskeleton in giant axonal neuropathy

Journal of Neurocytology, 1988
Intermediate filaments accumulate abnormally in a variety of cell types in individuals with human inherited giant axonal neuropathy (GAN). A characteristic feature of this disorder is the occurrence of focal axonal enlargements filled with accumulations of neurofilaments.
M, Donaghy, R H, King, P K, Thomas, J M, Workman   +3 more
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Fast Axonal Transport in Squid Giant Axon

Science, 1982
Video-enhanced contrast-differential interference contrast microscopy has revealed new features of axonal transport in the giant axon of the squid, where no movement had been detected previously by conventional microscopy. The newly discovered dominant feature is vast numbers of "submicroscopic" particles, probably 30- to 50-nanometer vesicles and ...
R D, Allen, J, Metuzals, I, Tasaki, S T, Brady, S P, Gilbert   +4 more
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Axonal oscillations in developing mammalian nerve axons

Physical Review E, 2005
We study neuronal spike propagation in a developing myelinated axon in various stages of its development through detailed computational modeling. Recently, a form of bursting (axonal bursting), has been reported in axons in developing nerves in the absence of potassium channels.
Shangyou, Zeng, Peter, Jung
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Axon-to-axon transmission in tullidora (buckthorn) neuropathy

Experimental Neurology, 1984
Oral administration of ether extracts of the tullidora ( Karwinskia humboldtiana ) fruit, which contains an identified neurotoxin, produced flaccid hind limb paralysis in cats after a latency of 4 to 7 weeks. Acute experiments were conducted after the paralysis was evident. Spinal roots of lumbar and sacral segments were transected as close as possible
A, Hernández-Cruz, E J, Muñoz-Martínez   +1 more
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Axon Resealing Following Transection Takes Longer in Central Axons Than in Peripheral Axons: Implications for Axonal Regeneration

Experimental Neurology, 2001
Injury to axons in the CNS leads to little regenerative repair and loss of function. Conversely, injury to axons in the PNS results in vigorous regrowth of severed axons, usually with restoration of function. This difference is generally attributed to a CNS environment that either cannot support or actively inhibits regeneration and/or a failure of CNS
F A, Ahmed, N A, Ingoglia, S C, Sharma
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Dynamic Condition of Protein in Axons and Axon Terminals

1971
Radioautographic studies performed with labeled amino acids visualize the complexity of the dynamic state of protein in nerve endings. One protein fraction, at least, is replaced at a rate of 4% per day. On the one hand, the loss of used protein in presynaptic axon terminals seems to be balanced by the arrival of new migratory proteins, synthesized in ...
B, Droz, H L, Koenig
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