Results 141 to 150 of about 2,305 (179)

The Azadirachtin Story

Angewandte Chemie International Edition, 2008
AbstractAzadirachtin has been the subject of intensive research within the scientific community ever since its isolation from the neem tree in 1968. There are now over 1000 publications relating to this natural product which cover all aspects of structural, biological and synthetic studies.
Gemma E, Veitch, Alistair, Boyer, Steven V, Ley   +2 more
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Structure and electronic properties of azadirachtin

Journal of Molecular Modeling, 2014
We performed a combined DFT and Monte Carlo (13)C NMR chemical-shift study of azadirachtin A, a triterpenoid that acts as a natural insect antifeedant. A conformational search using a Monte Carlo technique based on the RM1 semiempirical method was carried out in order to establish its preferred structure.
Elton A S, de Castro, Daniel A B, de Oliveira, Sergio A S, Farias, Ricardo, Gargano, João B L, Martins   +4 more
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Azadirachtin poisoning: a case report

Clinical Toxicology, 2010
The use of neem-based products is widespread in the Indian Subcontinent. Neem-based pesticides obtained from neem kernels are considered natural and safe. The toxic effects of ingestion and overdose of this pesticide in adults have not been described in this literature.
Ramya, Iyyadurai, V, Surekha, Sowmya, Sathyendra, Benny, Paul Wilson, K G, Gopinath   +4 more
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Asymmetric Formal Synthesis of Azadirachtin

Angewandte Chemie, 2015
AbstractAn asymmetric formal synthesis of azadirachtin, a potent insect antifeedant, was accomplished in 30 steps to Ley’s synthetic intermediate (longest linear sequence). The synthesis features: 1) rapid access to the optically active right‐hand segment starting from the known 5‐hydroxymethyl‐2‐cyclopentenone scaffold; 2) construction of the B and E ...
Naoki, Mori, Takeshi, Kitahara, Kenji, Mori, Hidenori, Watanabe   +3 more
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Azadirachtin

Zeitschrift für Angewandte Entomologie, 1984
AbstractVarious concentrations of azadirachtin, an isolate from Azadirachta indica A. Juss. were given to adults of Dysdercus koenigii F. topically and also by abdominal injections. Mortality of these bugs, provided azadirachtin by injections at 1 μg insect was nearly 50% by 7th day of treatment.
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Die Azadirachtin‐Story

Angewandte Chemie, 2008
AbstractDas Azadirachtin war Gegenstand intensiver Forschungen, seit es 1968 erstmals aus dem Niembaum isoliert wurde. Über 1000 Publikationen gibt es mittlerweile, die die strukturellen, biologischen und synthetischen Aspekte dieses Naturstoffs in allen Facetten beschreiben. In diesem Aufsatz geben wir einen Überblick über die langjährigen, weltweiten
Gemma E. Veitch, Alistair Boyer, Steven V. Ley   +2 more
openaire   +1 more source

The Synthesis of Azadirachtin: A Potent Insect Antifeedant

Chemistry – A European Journal, 2008
AbstractWe describe in full the first synthesis of the potent insect antifeedant azadirachtin through a highly convergent approach. An O‐alkylation reaction is used to unite decalin ketone and propargylic mesylate fragments, after which a Claisen rearrangement constructs the central C8C14 bond in a stereoselective fashion.
S. V. Ley, A. Abad Somovilla, J. C. Anderson, C. Ayats, R. Banteli, E. Beckmann, A. Boyer, M. G. Brasca, A. Brice, H. B. Broughton, B. J. Burke, E. Cleator, D. Craig, A. A. Denholm, R. M. Denton, T. Durand Reville, L. B. Gobbi, M. Gobel, B. L. Gray, R. B. Grossmann, C. E. Gutteridge, N. Hahn, S. L. Harding, D. C. Jennens, L. Jennens, P. J. Lovell, H. J. Lovell, M. L. de la Puente, H. C. Kolb, W. Koot, S. L. Maslen, C. F. McCusker, A. Mattes, A. R. Pape, A. Pinto, D. Santafianos, J. S. Scott, S. C. Smith, A. Q. Somers, C. D. Spilling, F. Stelzer, P. L. Toogood, R. M. Turner, G. E. Veitch, A. Wood, C. Zumbrunn   +45 more
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Azadirachtin, a scientific gold mine

Bioorganic & Medicinal Chemistry, 2009
Azadirachtin is a highly interesting compound both for its chemical structure, which required 18 years to solve, and its synthesis, which required another 22 years, and for its biological properties as a feeding deterrent for many insects and a growth disruptant for most insects and many other arthropods.
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In silico approach of azadirachtin binding with actins

Insect Biochemistry and Molecular Biology, 2007
In silico docking analysis reported here suggests that insect cellular cytoskeletal beta-actin could be the target of Azadirachtin A (Aza-the principle bioactive compound of neem seeds). The best docking energy of -40.09 kcal/mol at 8.73 A RMSD and predicted hydrogen bond between Arg210 and carboxymethyl group of Aza accompanied with seven hydrophobic ...
R, Pravin Kumar, M N, Manoj, Anil, Kush, R S, Annadurai   +3 more
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Studies Aimed at the Total Synthesis of Azadirachtin. A Modeled Connection of C-8 and C-14 in Azadirachtin

Organic Letters, 2002
[reaction: see text] Studies on the connection between the right and left segments of azadirachtin are described. The Ireland-Claisen rearrangement of Li-enolate of the modeled ester with dichlorodimethylsilane in toluene afforded the desired limonoid framework stereoselectively in good yield.
Takehiro, Fukuzaki, Satoshi, Kobayashi, Takamasa, Hibi, Yohei, Ikuma, Jun, Ishihara, Naoki, Kanoh, Akio, Murai   +6 more
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