Results 161 to 170 of about 911 (193)

Azaphilones from the Endophyte Diaporthe sp. and Their Toxicity

Chemistry & Biodiversity, 2022
AbstractChemotherapy and targeted therapies are increasingly used as conventional means to control tumor growth and prolong survival. Patient treated with anti‐neoplastic agents experience severe side effects, especially those cytotoxic chemotherapies. Exploring chemo agents with less side effects is the hot spot of anticancer research.
Fangfang Huang, Xiao Lin, Quanyi Lu
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Asymmetric Synthesis of (‐)‐Mitorubrin and Related Azaphilone Natural Products

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Jianglong, Zhu, John A, Porco
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Antimicrobial Azaphilones from the FungusHypoxylon multiforme

Planta Medica, 2005
Four new azaphilones named multiformins A - D together with a known compound 4 : 5:4':5'-tetrahydroxy-1 : 1'-binaphthyl were isolated from the methanolic stromatal extract of the xylariaceous ascomycete Hypoxylon multiforme. Their absolute structures were characterised by 2D-NMR, UV, IR, mass and CD spectroscopy.
Dang Ngoc, Quang, Toshihiro, Hashimoto, Marc, Stadler, Niko, Radulović, Yoshinori, Asakawa   +4 more
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Fungal Azaphilone Pigments as Promising Natural Colorants

Микробиология, 2023
Abstract—Microscopic fungi form and excrete numerous and diverse secondary metabolites, including pigments of various colors, which may be used as an alternative to chemical and plant colorants used in industry. Azaphilone compounds, first discovered in fungi of the genus Monascus, are among the promising classes of fungal pigments. The review analyzes
T. V. Antipova, V. P. Zhelifonova, K. V. Zaitsev, M. B. Vainshtein   +3 more
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Cytotoxic azaphilone alkaloids from Chaetomium globosum TY1

Bioorganic & Medicinal Chemistry Letters, 2013
Three novel azaphilone alkaloids, namely chaetomugilides A-C (1-3), together with three related compounds (4-6) were isolated from the methanol extract of Chaetomium globosum TY1, an endophytic fungus isolated from Ginkgo biloba. Their structures were elucidated on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis ...
Xiang, Li, Ye, Tian, Sheng-Xiang, Yang, Ya-Mei, Zhang, Jian-Chun, Qin   +4 more
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Unique processes yielding pure azaphilones in Talaromyces atroroseus

Applied Microbiology and Biotechnology, 2019
Azaphilones are a class of fungal pigments, reported mostly in association with Monascus species. In Asian countries, they are used as food colourants under the name of "red yeast rice" and their production process is well described. One major limitation of current production techniques of azaphilones is that they always occur in a mixture of yellow ...
Gerit, Tolborg, Anders S R, Ødum, Thomas, Isbrandt, Thomas Ostenfeld, Larsen, Mhairi, Workman   +4 more
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Cytotoxic and Antimalarial Azaphilones from Chaetomium longirostre

Journal of Natural Products, 2011
Four new azaphilones named longirostrerones A-D (1-4) and three known sterols, ergosteryl palmitate, ergosterol, and ergosterol peroxide, have been isolated from ethyl acetate extract of the fungus Chaetomium longirostre. These structures were determined by 1D and 2D NMR, IR, UV, MS, and CD spectroscopy.
Natcha, Panthama, Somdej, Kanokmedhakul, Kwanjai, Kanokmedhakul, Kasem, Soytong   +3 more
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Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors

Bioorganic & Medicinal Chemistry, 2010
A series of mold metabolites of Ascomycetes, structurally belonging to the class of azaphilones, were found to inhibit the heat shock protein Hsp90. In particular, bulgarialactone B was tested for its binding to Hsp90 using surface plasmon resonance and limited proteolysis assays and for its effects on Hsp90 client proteins expression in a series of ...
Loana, Musso, Sabrina, Dallavalle, Lucio, Merlini, Adriana, Bava, Gianluca, Nasini, Sergio, Penco, Giuseppe, Giannini, Chiara, Giommarelli, Andrea, De Cesare, Valentina, Zuco, Loredana, Vesci, Claudio, Pisano, Massimo, Castorina, Ferdinando, Milazzo, Maria Luisa, Cervoni, Fabrizio, Dal Piaz, Nunziatina, De Tommasi, Franco, Zunino   +17 more
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Phomoeuphorbins A–D, azaphilones from the fungus Phomopsis euphorbiae

Phytochemistry, 2008
Four azaphilones, named phomoeuphorbins A-D (1-4) were isolated from cultures of Phomopsis euphorbiae, an endophytic fungus isolated from Trewia nudiflora. Structures of 1-4 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. Phomoeuphorbins A and C exhibited very weak inhibitory activities
Bu-Zhu, Yu, Gao-Hong, Zhang, Zhi-Zhi, Du, Yong-Tang, Zheng, Jian-Chu, Xu, Xiao-Dong, Luo   +5 more
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Chaetoglobosins and azaphilones from Chaetomium globosum associated with Apostichopus japonicus

Applied Microbiology and Biotechnology, 2020
Increasing attention has recently been focused on complex symbiotic associations, for instance coral and its symbionts. Sea cucumber, harboring diverse fungi, has also attracted more and more attention for their functional diversity. Here, secondary metabolites produced by Chaetomium globosum associated with sea cucumber, Apostichopus japonicus, were ...
Jun Qi, Lan Jiang, Peipei Zhao, Haiyan Chen, Xiaopeng Jia, Liya Zhao, Huanqin Dai, Jiansen Hu, Changheng Liu, Sang Hee Shim, Xuekui Xia, Lixin Zhang   +11 more
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