Novel chlorinated and nitrogenated azaphilones with cytotoxic activities from the marine algal-derived fungus Chaetomium globosum 2020HZ23 [PDF]
Frontiers in Microbiology, 2023 Two novel chlorinated and nitrogenated azaphilones, namely N-butyl-2-aza-2-deoxychaetoviridin A (1) and N-hexyl-2-aza-2-deoxychaetoviridin A (2), along with a previously identified analogue, chaetoviridin A (3), were successfully obtained from Chaetomium
Zhong-Jie Gao +4 more
exaly +4 more sources
Nitrogen Enriched Solid-State Cultivation for the Overproduction of Azaphilone Red Pigments by Penicillium sclerotiorum SNB-CN111 [PDF]
Journal of Fungi, 2023 Azaphilones are microbial specialized metabolites employed as yellow, orange, red or purple pigments. In particular, yellow azaphilones react spontaneously with functionalized nitrogen groups, leading to red azaphilones.
Téo Hebra +2 more
doaj +2 more sources
Combining OSMAC, metabolomic and genomic methods for the production and annotation of halogenated azaphilones and ilicicolins in termite symbiotic fungi [PDF]
Scientific Reports, 2022 We gathered a collection of termite mutualistic strains from French Guiana to explore the metabolites of symbiotic microorganisms. Molecular networks reconstructed from a metabolomic analysis using LC–ESI–MS/MS methodology led us to identify two families
Téo Hebra +3 more
doaj +2 more sources
New Azaphilones from the Marine-Derived Fungus Penicillium sclerotiorum E23Y-1A with Their Anti-Inflammatory and Antitumor Activities [PDF]
Marine Drugs, 2023 Nine new azaphilones, including penicilazaphilones I–N (1, 2 and 6–9), epi-geumsanol D (3) and penidioxolanes C (4) and D (5) were isolated from the culture of the marine-derived fungus Penicillium sclerotiorum E23Y-1A.
Yanbo Zeng +7 more
doaj +2 more sources
Multiformin-Type Azaphilones Prevent SARS-CoV-2 Binding to ACE2 Receptor [PDF]
Cells, 2022 Protein microarray screenings identified fungal natural products from the azaphilone family as potent inhibitors of SARS-CoV-2 spike protein binding to host ACE2 receptors.
Linda Jansen-Olliges +7 more
doaj +2 more sources
Azaphilones produced by Penicillium maximae with their cell death-inducing activity on Adriamycin-treated cancer cell [PDF]
Genes and Environment, 2023 Background Heat shock proteins (Hsps) are overexpressed in several tumors and contribute to cell proliferation, metastasis, and anticancer drug resistance.
Takahiro Matsumoto +9 more
doaj +2 more sources
Recent Findings in Azaphilone Pigments [PDF]
Journal of Fungi, 2021 Filamentous fungi are known to biosynthesize an extraordinary range of azaphilones pigments with structural diversity and advantages over vegetal-derived colored natural products such agile and simple cultivation in the lab, acceptance of low-cost ...
Lúcia P. S. Pimenta +3 more
doaj +2 more sources
Inhibitory Effects of the Fungal Pigment Rubiginosin C on Hyphal and Biofilm Formation in Candida albicans and Candida auris [PDF]
Journal of Fungi, 2023 The two fungal human pathogens, Candida auris and Candida albicans, possess a variety of virulence mechanisms. Among them are the formation of biofilms to protect yeast against harsh conditions through the development of (pseudo)hyphae whilst also ...
Haoxuan Zeng +4 more
doaj +2 more sources
Phytotoxic Azaphilones From the Mangrove-Derived Fungus Penicillium sclerotiorum HY5 [PDF]
Frontiers in Microbiology, 2022 Mangrove is a unique marine ecosystem growing in the intertidal zone of tropical and subtropical coast, with the characteristics of hypoxia tolerance, high salinity, and high humidity.
Wei Wang +9 more
doaj +2 more sources
Bulbillosins A - E, azaphilones from Tengochaeta bulbillosa sp. nov. (Chaetomiaceae), a root endophyte of the Chinese medicinal plant Aster tataricus [PDF]
IMA FungusAster tataricus is a plant used in Traditional Chinese Medicine. From its roots, we isolated four endophytic fungi strains. After mass spectrometry analysis and subsequent molecular networking and dereplication, one of the strain’s extracts showed a ...
Diana Astrid Barrera-Adame +5 more
doaj +4 more sources