Recent Findings in Azaphilone Pigments [PDF]
Journal of Fungi, 2021 Filamentous fungi are known to biosynthesize an extraordinary range of azaphilones pigments with structural diversity and advantages over vegetal-derived colored natural products such agile and simple cultivation in the lab, acceptance of low-cost ...
Lúcia P. S. Pimenta +3 more
doaj +5 more sources
Novel chlorinated and nitrogenated azaphilones with cytotoxic activities from the marine algal-derived fungus Chaetomium globosum 2020HZ23 [PDF]
Frontiers in Microbiology, 2023 Two novel chlorinated and nitrogenated azaphilones, namely N-butyl-2-aza-2-deoxychaetoviridin A (1) and N-hexyl-2-aza-2-deoxychaetoviridin A (2), along with a previously identified analogue, chaetoviridin A (3), were successfully obtained from Chaetomium
Zhong-Jie Gao +4 more
exaly +4 more sources
Core Steps to the Azaphilone Family of Fungal Natural Products [PDF]
ChemBioChem, Volume 22, Issue 21, Page 3027-3036, November 3, 2021., 2021 Azaphilones are a polyketide‐based family of fungal natural products with a highly oxygenated bicyclic pyrone‐quinone structure, many of which have useful and interesting bioactivities. This minireview reveals the common steps in azaphilone biosynthetic pathways to aid the use of genome mining to identify orphan azaphilone biosynthetic gene clusters ...
Katherine Williams +3 more
wiley +7 more sources
Nitrogen Enriched Solid-State Cultivation for the Overproduction of Azaphilone Red Pigments by Penicillium sclerotiorum SNB-CN111 [PDF]
Journal of Fungi, 2023 Azaphilones are microbial specialized metabolites employed as yellow, orange, red or purple pigments. In particular, yellow azaphilones react spontaneously with functionalized nitrogen groups, leading to red azaphilones.
Téo Hebra +2 more
doaj +2 more sources
Azaphilones Pigments from the Fungus Penicillium hirayamae
Colorants, 2023 The use of fungal pigments as dyes is attractive for various industries. Fungal pigments arise a strong interest because they are suitable for large-scale industrial production and have none of the drawbacks of synthetic pigments.
Coralie Pavesi +8 more
doaj +4 more sources
New azaphilones from Aspergillus neoglaber [PDF]
AMB Express, 2020 Three new azaphilones, sassafrin E (1), sassafrin F (2), and sassafrinamine A (3), were isolated from the filamentous fungus Aspergillus neoglaber. The structures of the compounds were determined by nuclear magnetic resonance spectroscopy, and were found
Thomas Isbrandt +3 more
doaj +4 more sources
Combining OSMAC, metabolomic and genomic methods for the production and annotation of halogenated azaphilones and ilicicolins in termite symbiotic fungi [PDF]
Scientific Reports, 2022 We gathered a collection of termite mutualistic strains from French Guiana to explore the metabolites of symbiotic microorganisms. Molecular networks reconstructed from a metabolomic analysis using LC–ESI–MS/MS methodology led us to identify two families
Téo Hebra +3 more
doaj +2 more sources
Substrate-Selective Catalysis Enabled Synthesis of Azaphilone Natural Products. [PDF]
ACS Cent Sci, 2023 Achieving substrate-selectivity is a central element of nature’s approach to synthesis; relying on the ability of a catalyst to discriminate, based on small structural changes, which molecules will move forward in a synthesis. This approach can be challenging to duplicate in the laboratory, but can be powerful when realized.
Wang Y +4 more
europepmc +4 more sources
New Azaphilones from the Marine-Derived Fungus Penicillium sclerotiorum E23Y-1A with Their Anti-Inflammatory and Antitumor Activities [PDF]
Marine Drugs, 2023 Nine new azaphilones, including penicilazaphilones I–N (1, 2 and 6–9), epi-geumsanol D (3) and penidioxolanes C (4) and D (5) were isolated from the culture of the marine-derived fungus Penicillium sclerotiorum E23Y-1A.
Yanbo Zeng +7 more
doaj +2 more sources
Multiformin-Type Azaphilones Prevent SARS-CoV-2 Binding to ACE2 Receptor [PDF]
Cells, 2022 Protein microarray screenings identified fungal natural products from the azaphilone family as potent inhibitors of SARS-CoV-2 spike protein binding to host ACE2 receptors.
Linda Jansen-Olliges +7 more
doaj +2 more sources