Penazaphilones J–L, Three New Hydrophilic Azaphilone Pigments from Penicillium sclerotiorum cib-411 and Their Anti-Inflammatory Activity [PDF]
Molecules, 2023 Penazaphilones J–L (1–3), three new hydrophilic azaphilone pigments, as well as six known compounds, were discovered from the filamentous fungus Penicillium sclerotiorum cib-411.
Xia Zhang +5 more
doaj +2 more sources
Generation of Novel Natural Products by Disrupting Azaphilone Synthesis in Penicillum sclerotiorum E23Y-1A [PDF]
Marine DrugsMarine-derived filamentous fungi are a rich source of structurally diverse and biologically active natural products. However, many biosynthetic gene clusters (BGCs) in fungi remain silent under standard conditions.
Wenjun Chang +5 more
doaj +2 more sources
A Novel Azaphilone Muyophilone A From the Endophytic Fungus Muyocopron laterale 0307-2
Frontiers in Chemistry, 2021 Two known azaphilone derivatives, 4,6-dimethylcurvulinic acid (1) and austdiol (2), and their novel heterotrimer, muyophilone A (3), were isolated and identified from an endophytic fungus, Muyocopron laterale 0307-2.
Ke Wang, Longfei Li, Chao Yuan
exaly +3 more sources
Nitrogen Enriched Solid-State Cultivation for the Overproduction of Azaphilone Red Pigments by Penicillium sclerotiorum SNB-CN111 [PDF]
Journal of Fungi, 2023 Azaphilones are microbial specialized metabolites employed as yellow, orange, red or purple pigments. In particular, yellow azaphilones react spontaneously with functionalized nitrogen groups, leading to red azaphilones.
Téo Hebra +2 more
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Hydroxyl Radical Formation: A Key Mechanism and Regulatory Target in Monascin Photo-Degradation [PDF]
Journal of FungiMonascin, a yellow azaphilone pigment derived from Monascus fermentation, undergoes significant photo-degradation that limits its applications. This study reveals that free radical formation, particularly hydroxyl radicals (·OH) generated via H2O2 ...
Zhihan Shang +7 more
doaj +2 more sources
Cytotoxic Mechanism of Deep-Sea Fungus Chaetomium globosum YP-106 Metabolite Chaetomugilin O in Thyroid Cancer Cells [PDF]
Marine DrugsThis study investigated the potential of the deep-sea-derived fungal metabolite, chlorinated azaphilone compound chaetomugilin O, in the treatment of thyroid cancer.
Yaqin Fan +6 more
doaj +2 more sources
A New Azaphilone, Kasanosin C, from an Endophytic Talaromyces sp. T1BF
Molecules, 2010 The strain T1BF was isolated from the old bast tissue of Taxus yunnanensis and determined to be a member of Talaromyces. The extracts from the solid fermentation of Talaromycessp.
Ying Zeng, Pei-Ji Zhao, Liang-Qun Li
exaly +3 more sources
Penicilazaphilone C triggers ferroptosis in triple-negative breast cancer cells via the MDM2/p53/SLC7 A11/GPX4 pathway [PDF]
Discover OncologyPenicilazaphilone C (PAC) is a novel azaphilone isolated by our research team. While known for its antitumor properties, the potential of PAC to trigger ferroptosis in triple-negative breast cancer (TNBC) cells remains unexplored.
Hua-Tao Liang +8 more
doaj +2 more sources
Isolation and Characterization of Antimicrobial Metabolites from the Sophora tonkinensis-Associated Fungus Penicillium sp. GDGJ-N37 [PDF]
MoleculesChemical investigation of Penicillium sp. GDGJ-N37, a Sophora tonkinensis-associated fungus, yielded two new azaphilone derivatives, N-isoamylsclerotiorinamine (1) and 7-methoxyl-N-isoamylsclerotiorinamine (2), and four known azaphilones (3–6), together ...
Lili Huang +9 more
doaj +2 more sources
OSMAC-Driven Discovery of Six New Alkaloids from the Cold-Seep-Derived Fungus Talaromyces amestolkiae HDN21-0307 [PDF]
Marine DrugsSix new alkaloid compounds, including two rare aromatic nitrile compounds talaronitriles A–B (1–2), a novel oxime-functionalized azadiphilone analogue talarooxime A (3), a new phenylhydrazone alkaloid talarohydrazone E (4), and two new dipeptide ...
Xinsheng Huang +8 more
doaj +2 more sources