Results 41 to 50 of about 911 (193)
Chemistry – A European Journal, 2020 AbstractThe diversity of azaphilones in stromatal extracts of the fungus Hypoxylon fragiforme was investigated and linked to their biosynthetic machineries by using bioinformatics. Nineteen azaphilone‐type compounds were isolated and characterized by NMR spectroscopy and mass spectrometry, and their absolute stereoconfigurations were assigned by using ...
Kevin Becker +5 more
openaire +3 more sources
Monasone Naphthoquinone Biosynthesis and Resistance in
mBio, 2020 Despite the important biological activities of natural product naphthoquinones, the biosynthetic pathways of and resistance mechanisms against such compounds remain poorly understood in fungi.
Mu Li +7 more
doaj +1 more source
Early Oxidative Transformations During the Biosynthesis of Terrein and Related Natural Products
Chemistry – A European Journal, Volume 27, Issue 46, Page 11895-11903, August 16, 2021., 2021 Heterologous expression of two related biosynthetic gene clusters from Aspergillus terreus and Roussoella sp. DLM33 confirmed a conserved flavin‐dependent monooxygenase that initiates the oxidative decarboxylation of the key intermediate (dichloro‐) 6‐hydroxymellein. Further in vitro studies imply that both pathways diverge after this initial oxidation,
Lukas Kahlert +6 more
wiley +1 more source
Enzymatic Late‐Stage Modifications: Better Late Than Never
Angewandte Chemie International Edition, Volume 60, Issue 31, Page 16824-16855, July 26, 2021., 2021 Late‐stage modification is an indispensable approach for compound diversification in synthesis. Since enzymes offer particularly powerful means for mild, catalyst‐controlled functionalisations, in recent years several novel biocatalytic methods have emerged enabling a broad array of orthogonal reactions.
Elvira Romero +7 more
wiley +1 more source
Molecules, 2012 A new azaphilonidal derivative, monapurpyridine A (MPA), has recently been isolated from the fermented products of Monascus purpureus NTU 568. The structure of MPA was elucidated by nuclear magnetic resonance (1H-NMR, 13C-NMR, COSY, HMQC, and HMBC) and ...
Tzu-Ming Pan +5 more
doaj +1 more source
, 2021 Two known azaphilone derivatives, 4,6-dimethylcurvulinic acid (1) and austdiol (2), and their novel heterotrimer, muyophilone A (3), were isolated and identified from an endophytic fungus, Muyocopron laterale 0307-2.
Longfei Li (589618) +6 more
core +1 more source
Ancestral Sequence Reconstruction to Enable Biocatalytic Synthesis of Azaphilones. [PDF]
J Am Chem SocBiocatalysis can be powerful in organic synthesis but is often limited by enzymes' substrate scope and selectivity. Developing a biocatalytic step involves identifying an initial enzyme for the target reaction followed by optimization through rational design, directed evolution, or both.
Chiang CH +4 more
europepmc +3 more sources
Table1_A Novel Azaphilone Muyophilone A From the Endophytic Fungus Muyocopron laterale 0307-2.DOCX
, 2021 Two known azaphilone derivatives, 4,6-dimethylcurvulinic acid (1) and austdiol (2), and their novel heterotrimer, muyophilone A (3), were isolated and identified from an endophytic fungus, Muyocopron laterale 0307-2.
Longfei Li (589618) +6 more
core +1 more source
, 2021 Two known azaphilone derivatives, 4,6-dimethylcurvulinic acid (1) and austdiol (2), and their novel heterotrimer, muyophilone A (3), were isolated and identified from an endophytic fungus, Muyocopron laterale 0307-2.
Longfei Li (589618) +6 more
core +1 more source
Marine Drugs, 2013 Microbial studies of the Mediterranean sponge Tethya aurantium led to the isolation of the fungus Bartalinia robillardoides strain LF550. The strain produced a number of secondary metabolites belonging to the chloroazaphilones.
Johannes F. Imhoff +5 more
doaj +1 more source