Ancestral Sequence Reconstruction to Enable Biocatalytic Synthesis of Azaphilones. [PDF]
J Am Chem SocBiocatalysis can be powerful in organic synthesis but is often limited by enzymes' substrate scope and selectivity. Developing a biocatalytic step involves identifying an initial enzyme for the target reaction followed by optimization through rational design, directed evolution, or both.
Chiang CH +4 more
europepmc +3 more sources
Proangiogenic Azaphilones from the Marine-Derived Fungus Neopestalotiopsis sp. HN-1-6 [PDF]
Marine DrugsDeveloping novel, safe, and efficient proangiogenic drugs is an important approach for the prevention and treatment of cardiovascular diseases. In this study, 4 new compounds, including 3 azaphilones (1–3) and 1 dihydroisocoumarin (4), as well as 13 ...
Ting Feng +6 more
doaj +2 more sources
From Pigment Chemistry to Nanomaterials: Fungal Pigments as Reducing and Stabilizing Agents in Green Nanoparticle Synthesis [PDF]
MicroorganismsFungal pigments have gained attention as eco-friendly and versatile materials for green nanotechnology because of their varied chemical structures, inherent redox properties, and strong metal ion-binding capabilities. These pigments, such as polyketides,
Akshay Chavan +4 more
doaj +2 more sources
Isolation and Characterization of Antimicrobial Metabolites from the Sophora tonkinensis-Associated Fungus Penicillium sp. GDGJ-N37 [PDF]
MoleculesChemical investigation of Penicillium sp. GDGJ-N37, a Sophora tonkinensis-associated fungus, yielded two new azaphilone derivatives, N-isoamylsclerotiorinamine (1) and 7-methoxyl-N-isoamylsclerotiorinamine (2), and four known azaphilones (3–6), together ...
Lili Huang +9 more
doaj +2 more sources
Novel bioactive compounds from marine-derived endosymbiotic Penicillium fungi reported during 2020–2025 [PDF]
Natural Products and BioprospectingMarine-derived Penicillium fungus gained significant attention in recent years due to their potential as a valuable source of unique natural compounds with a wide range of chemical structures and bioactive capabilities.
Sarah A. Omran +3 more
doaj +2 more sources
Generation of Novel Natural Products by Disrupting Azaphilone Synthesis in Penicillum sclerotiorum E23Y-1A [PDF]
Marine DrugsMarine-derived filamentous fungi are a rich source of structurally diverse and biologically active natural products. However, many biosynthetic gene clusters (BGCs) in fungi remain silent under standard conditions.
Wenjun Chang +5 more
doaj +2 more sources
The Impact of the Culture Regime on the Metabolome and Anti-Phytopathogenic Activity of Marine Fungal Co-Cultures [PDF]
Marine DrugsCo-cultivation, coupled with the OSMAC approach, is considered an efficient method for expanding microbial chemical diversity through the activation of cryptic biosynthetic gene clusters (BGCs).
Mohammed Zawad Reza +2 more
doaj +2 more sources
Biosynthesis of azaphilones: a review [PDF]
Natural Product Reports, 2021 Biosynthetic pathways for azaphilones are addressed from a genomic point of view.
Coralie Pavesi +5 more
openaire +3 more sources
Metabolites, 2021 Microorganisms associated with termites are an original resource for identifying new chemical scaffolds or active metabolites. A molecular network was generated from a collection of strain extracts analyzed by liquid chromatography coupled to tandem high-
Téo Hebra +5 more
doaj +1 more source
Anti-Inflammatory Azaphilones from the Edible Alga-Derived Fungus Penicillium sclerotiorum
Marine Drugs, 2021 To discover the new medical entity from edible marine algae, our continuously natural product investigation focused on endophytes from marine macroalgae Grateloupia sp.
Hui-Chun Wang +5 more
doaj +1 more source