Results 41 to 50 of about 806 (182)
, 2022 Monascus fermented rice, also known as red yeast rice, exhibits a broad spectrum of biological activities due to its chemical constituents, such as monacolins and azaphilone pigments.
Busaba Yongsmith (11866495) +5 more
core +1 more source
European Journal of Organic Chemistry, Volume 2021, Issue 36, Page 5094-5103, September 24, 2021., 2021 Rubiginosins Z‐W, novel azaphilone pigments from stromata of Hypoxylon rubiginosum and H. texense, were isolated. Extensive HRMS, NMR, and ECD analysis revealed their stereochemistry and yielded missing configurations of known congeners. Unlike the related H. fragiforme, H. rubiginosum and H.
Kevin Becker +3 more
wiley +1 more source
Multiformin-Type Azaphilones Prevent SARS-CoV-2 Binding to ACE2 Receptor
, 2023 Protein microarray screenings identified fungal natural products from the azaphilone family as potent inhibitors of SARS-CoV-2 spike protein binding to host ACE2 receptors.
Jansen-Olliges, Linda +7 more
core +2 more sources
Early Oxidative Transformations During the Biosynthesis of Terrein and Related Natural Products
Chemistry – A European Journal, Volume 27, Issue 46, Page 11895-11903, August 16, 2021., 2021 Heterologous expression of two related biosynthetic gene clusters from Aspergillus terreus and Roussoella sp. DLM33 confirmed a conserved flavin‐dependent monooxygenase that initiates the oxidative decarboxylation of the key intermediate (dichloro‐) 6‐hydroxymellein. Further in vitro studies imply that both pathways diverge after this initial oxidation,
Lukas Kahlert +6 more
wiley +1 more source
Ancestral Sequence Reconstruction to Enable Biocatalytic Synthesis of Azaphilones. [PDF]
J Am Chem SocBiocatalysis can be powerful in organic synthesis but is often limited by enzymes' substrate scope and selectivity. Developing a biocatalytic step involves identifying an initial enzyme for the target reaction followed by optimization through rational design, directed evolution, or both.
Chiang CH +4 more
europepmc +3 more sources
Enzymatic Late‐Stage Modifications: Better Late Than Never
Angewandte Chemie International Edition, Volume 60, Issue 31, Page 16824-16855, July 26, 2021., 2021 Late‐stage modification is an indispensable approach for compound diversification in synthesis. Since enzymes offer particularly powerful means for mild, catalyst‐controlled functionalisations, in recent years several novel biocatalytic methods have emerged enabling a broad array of orthogonal reactions.
Elvira Romero +7 more
wiley +1 more source
Substrate-Selective Catalysis Enabled Synthesis of Azaphilone Natural Products. [PDF]
ACS Cent Sci, 2023 Achieving substrate-selectivity is a central element of nature's approach to synthesis. By relying on the ability of a catalyst to discriminate between components in a mixture, control can be exerted over which molecules will move forward in a synthesis.
Wang Y +4 more
europepmc +4 more sources
Systematic Metabolic Engineering for the Production of Azaphilones in Monascus purpureus HJ11
, 2022 Fungal azaphilones have attracted considerable interest as they exhibit great potential in food and pharmacological industries. However, there is a severe bottleneck in the low production in wild strains and the ability to genetically engineer azaphilone-
Xuetuan Wei (3749068) +13 more
core +1 more source
Frontiers in Microbiology, 2022 Five new chloro-azaphilones, chaetofanixins A–E (1–5), and five known analogs (6–10) were isolated and identified from the hadal trench-derived fungus Chaetomium globosum YP-106.
Yaqin Fan +8 more
doaj +1 more source
Journal of Fungi, 2021 Monascus species are asexually or sexually reproduced homothallic fungi that can produce a red colorant, specifically the so-called red yeast rice or Anka, which is used as a food ingredient in Asia. Traditional experiences of using Monascus for treating
Ho-Cheng Wu +5 more
doaj +1 more source