Influence of probiotics and deoxycholate on azathioprine transport in the PAMPA model: insights into pharmacomicrobiomics and interindividual variability in drug response. [PDF]
Front PharmacolIntroductionInterindividual variability in drug response presents a major clinical challenge, necessitating a deeper understanding of contributing factors.
Đanić M +6 more
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Azathioprine in Rheumatoid Arthritis [PDF]
BMJ, 1969 The ability of azathioprine to reduce the corticosteroid requirements of patients with severe rheumatoid arthritis was tested under double-blind conditions against placebo. After 12 months a significant mean dose reduction of 36% was achieved without undue side-effects.
Matthew Mason +5 more
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Proactive pharmacogenomics in azathioprine-treated pediatric inflammatory bowel disease at a Chinese tertiary hospital. [PDF]
Front PharmacolBackgroundDespite the emergence of numerous innovative targeted therapies for the management of pediatric inflammatory bowel disease (IBD), azathioprine continues to be a pivotal first-line therapeutic agent.
Long CY, Huang Y.
europepmc +2 more sources
Perspectives in clinical research on Azathioprine for steroid-dependent ulcerative colitis. [PDF]
Front Med (Lausanne)This study explores the application of Azathioprine in the treatment of ulcerative colitis (UC) and the challenges associated with its long-term use. While short-term studies demonstrate the efficacy of Azathioprine in steroid-dependent UC, long-term ...
Qu YT, Ding JY, Pan W, Liu FR, Dong AL.
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Azathioprine in Psoriasis [PDF]
Proceedings of the Royal Society of Medicine, 1973 D.D. MUNRO
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A Case of Azathioprine Induced Severe Myelosuppression and Alopecia Totalis in IgA Nephropathy [PDF]
Childhood Kidney Diseases, 2017 Azathioprine is commonly used as immunosuppressive therapy for various inflammatory diseases including chronic glomerulonephritis. Myelosuppression is a common side effect of azathioprine, resulting in the need for dose reduction.
Jae Choon Kim +6 more
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Journal of Nepal Medical Association, 2016 Introduction: Immune thrombocytopenic purpura remains common blood disease in Nepal. Azathioprine is an oral immunosupressive medicine which has been used widely in various autoimmune disease and solid organ transplant patients. It is inexpensive, easily
Bishesh Sharma Poudyal +5 more
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Azathioprine antagonizes aberrantly elevated lipid metabolism and induces apoptosis in glioblastoma
iScience, 2021 Summary: Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor with poor survival rate. Temozolomide (TMZ) is used as standard chemotherapy to treat GBM, but a large number of patients either respond poorly and/or develop resistance ...
Hye Jin Nam +8 more
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Azathioprine versus beta interferons for relapsing-remitting multiple sclerosis: a multicentre randomized non-inferiority trial. [PDF]
PLoS ONE, 2014 For almost three decades in many countries azathioprine has been used to treat relapsing-remitting multiple sclerosis. However its efficacy was usually considered marginal and following approval of β interferons for this indication it was no longer ...
Luca Massacesi +10 more
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Taiwanese Journal of Obstetrics & Gynecology, 2023 Objective: Azathioprine, a prodrug of 6-mercaptopurine (6-MP), is used in the treatment of inflammatory bowel disease and may be continued during pregnancy. Acute cholestatic liver injury has been reported to occur with azathioprine.
Maya Frank Wolf +6 more
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