Results 1 to 10 of about 107,258 (321)

Azathioprine versus beta interferons for relapsing-remitting multiple sclerosis: a multicentre randomized non-inferiority trial. [PDF]

PLoS ONE, 2014
For almost three decades in many countries azathioprine has been used to treat relapsing-remitting multiple sclerosis. However its efficacy was usually considered marginal and following approval of β interferons for this indication it was no longer ...
Luca Massacesi, Irene Tramacere, Salvatore Amoroso, Mario A Battaglia, Maria Donata Benedetti, Graziella Filippini, Loredana La Mantia, Anna Repice, Alessandra Solari, Gioacchino Tedeschi, Clara Milanese   +10 more
doaj   +3 more sources

Influence of probiotics and deoxycholate on azathioprine transport in the PAMPA model: insights into pharmacomicrobiomics and interindividual variability in drug response [PDF]

Frontiers in Pharmacology
IntroductionInterindividual variability in drug response presents a major clinical challenge, necessitating a deeper understanding of contributing factors.
Maja Đanić, Nebojša Pavlović, Natalija Dedić, Dragana Zaklan, Slavica Lazarević, Bojan Stanimirov, Momir Mikov   +6 more
doaj   +2 more sources

A Case of Azathioprine Induced Severe Myelosuppression and Alopecia Totalis in IgA Nephropathy [PDF]

Childhood Kidney Diseases, 2017
Azathioprine is commonly used as immunosuppressive therapy for various inflammatory diseases including chronic glomerulonephritis. Myelosuppression is a common side effect of azathioprine, resulting in the need for dose reduction.
Jae Choon Kim, Ye Kyung Kim, Hye Sun Hyun, Eu Jin Park, Hee Gyung Kang, Il Soo Ha, Hae Il Cheong   +6 more
doaj   +1 more source

Safety and Efficacy of Azathioprine as a Second Line Therapy for Primary Immune Thrombocytopenic Purpura

Journal of Nepal Medical Association, 2016
Introduction: Immune thrombocytopenic purpura remains common blood disease in Nepal. Azathioprine is an oral immunosupressive medicine which has been used widely in various autoimmune disease and solid organ transplant patients. It is inexpensive, easily
Bishesh Sharma Poudyal, Binaya Sapkota, Gentle Sunder Shrestha, Sujan Thapalia, Bishal Gyawali, Sampurna Tuladhar   +5 more
doaj   +3 more sources

Azathioprine and 6-mercaptopurine-induced intrahepatic cholestasis of pregnancy: Case report and review of the literature

Taiwanese Journal of Obstetrics & Gynecology, 2023
Objective: Azathioprine, a prodrug of 6-mercaptopurine (6-MP), is used in the treatment of inflammatory bowel disease and may be continued during pregnancy. Acute cholestatic liver injury has been reported to occur with azathioprine.
Maya Frank Wolf, Ronen Sloma, Luiza Akria, Eli Rimon, Yifat Wiener, Michal Carmiel Haggai, Lior Lowenstein   +6 more
doaj   +1 more source

Predicted expression of genes involved in the thiopurine metabolic pathway and azathioprine discontinuation due to myelotoxicity

Clinical and Translational Science, 2022
TPMT and NUDT15 variants explain less than 25% of azathioprine‐associated myelotoxicity. There are 25 additional genes in the thiopurine pathway that could also contribute to azathioprine myelotoxicity.
Laura L. Daniel, Alyson L. Dickson, Jacy T. Zanussi, Tyne W. Miller‐Fleming, Peter S. Straub, Wei‐Qi Wei, W. Dale Plummer, William D. Dupont, Ge Liu, Prathima Anandi, Tyler S. Reese, Kelly A. Birdwell, Vivian K. Kawai, Adriana M. Hung, Nancy J. Cox, QiPing Feng, C. Michael Stein, Cecilia P. Chung   +17 more
doaj   +1 more source

Azathioprine antagonizes aberrantly elevated lipid metabolism and induces apoptosis in glioblastoma

iScience, 2021
Summary: Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor with poor survival rate. Temozolomide (TMZ) is used as standard chemotherapy to treat GBM, but a large number of patients either respond poorly and/or develop resistance ...
Hye Jin Nam, Young Eun Kim, Byoung-San Moon, Hyun Young Kim, Daeyoung Jung, Seungho Choi, Jeong Woon Jang, Do-Hyun Nam, Heeyeong Cho   +8 more
doaj   +1 more source

Use of thiopurines in inflammatory bowel disease: an update [PDF]

Intestinal Research, 2022
Inflammatory bowel disease (IBD), once considered a disease of the Western hemisphere, has emerged as a global disease. As the disease prevalence is on a steady rise, management of IBD has come under the spotlight.
Arshdeep Singh, Ramit Mahajan, Saurabh Kedia, Amit Kumar Dutta, Abhinav Anand, Charles N. Bernstein, Devendra Desai, C. Ganesh Pai, Govind Makharia, Harsh Vardhan Tevethia, Joyce WY Mak, Kirandeep Kaur, Kiran Peddi, Mukesh Kumar Ranjan, Perttu Arkkila, Rakesh Kochhar, Rupa Banerjee, Saroj Kant Sinha, Siew Chien Ng, Stephen Hanauer, Suhang Verma, Usha Dutta, Vandana Midha, Varun Mehta, Vineet Ahuja, Ajit Sood   +25 more
doaj   +1 more source

Change in hematologic indices over time in pediatric inflammatory bowel disease treated with azathioprine [PDF]

, 2010
Azathioprine leads to changes in mean corpuscular volume (MCV) and white blood cell (WBC) indices reflecting efficacy or toxicity. Understanding the interactions between bone marrow stem cells and azathioprine could highlight abnormal response patterns ...
A Timmer, AC Mackey, AG Fraser, Chris J. Taylor, CN Bernstein, CW Thomas Jr, David I. Campbell, DH Present, Dhandapani Ashok, I Tiede, J Glas, LJ Derijks, P Karran, S Al-Safi, Sally A. Connolly, Samantha J. Cordell, Sherman Soman, W Disanti, Y Masunaga   +18 more
core   +2 more sources

Azathioprine Hypersensitivity Syndrome during Treatment of Severe Interstitial Lung Disease with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis

Case Reports in Pulmonology, 2020
Azathioprine is used to treat anti-neutrophil cytoplasmic antibody- (ANCA-) associated vasculitis. Azathioprine hypersensitivity syndrome is often missed.
Eri Nakano, Tomohiko Asakawa, Mea Asou, Eri Nohara, Tomoyuki Seki, Makoto Araki   +5 more
doaj   +1 more source