Results 21 to 30 of about 133,046 (390)

Change in hematologic indices over time in pediatric inflammatory bowel disease treated with azathioprine [PDF]

, 2010
Azathioprine leads to changes in mean corpuscular volume (MCV) and white blood cell (WBC) indices reflecting efficacy or toxicity. Understanding the interactions between bone marrow stem cells and azathioprine could highlight abnormal response patterns ...
A Timmer, AC Mackey, AG Fraser, Chris J. Taylor, CN Bernstein, CW Thomas Jr, David I. Campbell, DH Present, Dhandapani Ashok, I Tiede, J Glas, LJ Derijks, P Karran, S Al-Safi, Sally A. Connolly, Samantha J. Cordell, Sherman Soman, W Disanti, Y Masunaga   +18 more
core   +2 more sources

Posterior Reversible Encephalopathy Syndrome and Azathioprine [PDF]

, 2019
Posterior reversible encephalopathy syndrome (PRES) is a rare syndrome that presents with neurological manifestations, often associated with arterial hypertension.
Corte-Real, A, Vilas-Boas, S
core   +2 more sources

Infliximab, azathioprine, or combination therapy for Crohn's disease.

New England Journal of Medicine, 2010
BACKGROUND The comparative efficacy and safety of infliximab and azathioprine therapy alone or in combination for Crohn's disease are unknown. METHODS In this randomized, double-blind trial, we evaluated the efficacy of infliximab monotherapy ...
J. Colombel, W. Sandborn, W. Reinisch, G. Mantzaris, A. Kornbluth, D. Rachmilewitz, S. Lichtiger, G. D'Haens, R. Diamond, D. Broussard, K. Tang, C. J. van der Woude, P. Rutgeerts   +12 more
semanticscholar   +1 more source

Case report: NUDT15 polymorphism and severe azathioprine-induced myelosuppression in a young Chinese female with systematic lupus erythematosus: a case analysis and literature review

Frontiers in Pharmacology, 2023
Azathioprine is clinically used as an immunosuppressant for treating autoimmune diseases. However it has narrow therapeutic indices due to frequent myelosuppression.
Juan Gu, Yupei Lin, Yuhe Wang
doaj   +1 more source

The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature

Nature Communications, 2018
Cutaneous squamous cell carcinoma (cSCC) has a high tumour mutational burden (50 mutations per megabase DNA pair). Here, we combine whole-exome analyses from 40 primary cSCC tumours, comprising 20 well-differentiated and 20 moderately/poorly ...
G. Inman, Jun Wang, A. Nagano, L. Alexandrov, K. Purdie, Richard G. Taylor, V. Sherwood, J. Thomson, S. Hogan, L. Spender, A. South, M. Stratton, C. Chelala, C. Harwood, C. Proby, I. Leigh   +15 more
semanticscholar   +1 more source

Pediatric IBD patients show medication and disease activity dependent changes in NK cell and CD4 memory T cell populations

Frontiers in Pediatrics, 2023
ObjectivesCD4+ memory T cells facilitate long-termed adaptive immune responses while NK cells are predominately rapid effector cells with significant functions for both intestinal homeostasis and inflammation.
Angeliki Pappa, Julia Mührer, Patricia Gast, Sudheendra Hebbar Subramanyam, Kim Ohl, Moritz Muschaweck, Norbert Wagner, Tobias Wenzl, Klaus Tenbrock   +8 more
doaj   +1 more source

Prevention of thiopurine-induced early leukopenia in a Korean pediatric patient with Crohn’s disease who turned out to possess homozygous mutations in R139C [PDF]

Yeungnam University Journal of Medicine, 2020
Homozygous mutations in NUDT15 R139C are known as the major factor associated with thiopurine-induced early leukopenia, particularly in Asian patients. Therefore, NUDT15 genotyping is currently recommended before thiopurine treatment to identify patients
Jaewoan Bae, Byung-Ho Choe, Ben Kang
doaj   +1 more source

Azathioprine and 6-mercaptopurine for maintenance of surgically-induced remission in Crohn’s disease [PDF]

, 2014
Background Crohn’s disease (CD) is a chronic relapsing inflammatory condition. Many patients fail to achieve remission with medical management and require surgical interventions.
Angelberger, Angelberger, Ardizzone, Armuzzi, Armuzzi, Armuzzi, Benchimol, Bernell, Colonna, D'Haens, D'Haens, Dilger, Doherty, Ferrante, Gordon, Guyatt, Hafraoui, Hanauer, Hanauer, Herfarth, Herfarth, Higgins, Higgins, Korelitz, Manosa, Mañosa, Nos, Pitkin, Prefontaine, Regueiro, Reinisch, Reinisch, Reinisch, Reinisch, Rolfe, Rutgeerts, Savarino, Savarino, Savarino, Schünemann, Steinhart, Williams   +41 more
core   +1 more source

LB004A RANDOMIZED, CONTROLLED TRIAL OF RITUXIMAB VERSUS AZATHIOPRINE AFTER INDUCTION OF REMISSION WITH RITUXIMAB FOR PATIENTS WITH ANCA-ASSOCIATED VASCULITIS AND RELAPSING DISEASE

, 2020
Rituximab is an effective therapy for induction of remission in ANCA-associated vasculitis (AAV). However, the effect of rituximab is not sustained, and subsequent relapse rates are high, especially in patients with a history of relapse.
Rona M. Smith, D. Jayne, P. Merkel
semanticscholar   +1 more source

Neuropsychiatric Outcome of Children Born to Women With Systemic Lupus Erythematosus and Exposed in Utero to Azathioprine: A Case-Control Study

Frontiers in Pharmacology, 2020
Objective: The long-term outcome of children born to SLE mothers still represents a controversial topic in literature, with some studies reporting a possible increased prevalence of different neurologic and psychiatric diseases (NPD), including ...
Maria-Grazia Lazzaroni, Maria-Grazia Lazzaroni, Laura Andreoli, Laura Andreoli, Francesca Crisafulli, Francesca Crisafulli, Francesco Tamborini, Irene Debeni, Valentina Binda, Cecilia Nalli, Jessica Galli, Jessica Galli, Elisa Fazzi, Elisa Fazzi, Gabriella Moroni, Franco Franceschini, Franco Franceschini, Angela Tincani, Angela Tincani, Angela Tincani   +19 more
doaj   +1 more source