Results 91 to 100 of about 6,873 (149)

A new tri-functional azetidine compound for self-curing aqueous-based PU system [PDF]

[[abstract]]A mono-azetidine compound had been demonstrating a ring opening reaction with carboxylic acid (e.g., trimethylacetic acid, TMAA) and that resulted in an amino ester bond formation at ambient temperature.
Chen, Chen, Chen, Chen, Chen, Chen, Coogan, Huang, Huang, Lai, Lai, Lai, Ling, Shao, Wadsworth, Wadsworth, Wang, Wang, Wang   +18 more
core   +1 more source

The Nitrofuran-Warhead-Equipped Spirocyclic Azetidines Show Excellent Activity against Mycobacterium tuberculosis

Molecules
A series of 21 new 7′H-spiro[azetidine-3,5′-furo [3,4-d]pyrimidine]s substituted at the pyrimidine ring second position were synthesized. The compounds showed high antibacterial in vitro activity against M. tuberculosis.
Kristina Komarova, Lyubov Vinogradova, Alexey Lukin, Maxim Zhuravlev, Dmitry Deniskin, Mikhail Chudinov, Maxim Gureev, Marine Dogonadze, Natalia Zabolotnykh, Tatiana Vinogradova, Anastasia Lavrova, Petr Yablonskiy   +11 more
doaj   +1 more source

Recent Advances in the Synthesis of 2-Substituted Oxetanes [PDF]

, 2015
Bull, JA, Davis, O
core   +1 more source

In-silico molecular docking, ADME study of new azetidin-2-one derivatives having imidazole moiety targeting cyclooxygenase-2 Enzyme

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Background: Non-steroidal anti-inflammatory drugs re commonly used medications as anti-inflammatory, analgesic and antipyretic agents. However, they have many limitations due to the adverse effect, such as gastric irritation and gastric ulceration ...
Aya Ahmed Shakir Hasson , Monther Faisal Mahdi   +1 more
doaj   +1 more source

Recent advances in the late-stage modification of complex bioactive molecules with oxetanes and azetidines

Tetrahedron Chem
Oxetanes and azetidines have emerged as increasingly prominent motifs in medicinal chemistry, offering compact, polar frameworks that finely modulate the physicochemical properties of drug candidates.
Yuqing Wang, Dayu Tian, Hai-Jun Zhang
doaj   +1 more source

Synthesis and study of the reactivity of functionalized small-membered azaheterocyclic amino acid derivatives [PDF]

, 2012
Žukauskaitė, Asta
core   +1 more source

4″-Methyl-<i>S</i>-Adenosyl-l-Methionines Are Substrates for 4-Methylazetidinecarboxylic Acid Synthases. [PDF]

ACS Chem Biol
Nagano N, Kiuchi K, Minato A, Sato S, Moriwaki Y, Müller R, Eguchi T, Kudo F.   +7 more
europepmc   +1 more source

Discovery and Development of a Small-Molecule Inhibitor Targeting the GAS41 YEATS Domain in Nonsmall Cell Lung Cancer. [PDF]

J Med Chem
Listunov D, Winkler A, Ray J, Linhares BM, Clegg B, Weaver S, Kim E, Zari S, Park SR, Zolov SN, Chuikov S, Zhao L, Shah YM, Keshamouni VG, Grembecka J, Cierpicki T.   +15 more
europepmc   +1 more source

Discovery and Mechanism of a Diiron Enzyme in Ethylidene Azetidine Formation. [PDF]

J Am Chem Soc
Shen Y, Zheng YC, Palacios PM, Wang K, Maggiolo AO, Guo Y, Chang WC.   +6 more
europepmc   +1 more source

A Convenient Synthesis of CHF₂O-Containing Pyrrolidines and Related Compounds — Prospective Building Blocks for Drug Discovery

SynOpen
Kostiantyn Levchenko, Ivan Virstiuk, Daria Menshykova, Nazariy Pokhodylo   +3 more
doaj   +1 more source