Results 121 to 130 of about 5,133 (208)

Discovery and Development of a Small-Molecule Inhibitor Targeting the GAS41 YEATS Domain in Nonsmall Cell Lung Cancer. [PDF]

J Med Chem
Listunov D, Winkler A, Ray J, Linhares BM, Clegg B, Weaver S, Kim E, Zari S, Park SR, Zolov SN, Chuikov S, Zhao L, Shah YM, Keshamouni VG, Grembecka J, Cierpicki T.   +15 more
europepmc   +1 more source

Structural and mechanistic insights into azetidine-associated αKG-NHFe enzyme OkaE with multifunctional catalysis. [PDF]

Nat Commun
Wang X, Yu J, Liu T, Zhang X, Ju M, Xie Z, Naowarojna N, Ping L, Dong Y, Gong B, Xie Y, Nie Y, Hsiang T, Wu R, Zhang L, Liu P, Zhu G, Yan W, Liu X.   +18 more
europepmc   +1 more source

Discovery and Mechanism of a Diiron Enzyme in Ethylidene Azetidine Formation. [PDF]

J Am Chem Soc
Shen Y, Zheng YC, Palacios PM, Wang K, Maggiolo AO, Guo Y, Chang WC.   +6 more
europepmc   +1 more source

Optimization Leading to a Potent and Selective Cbl‑b Inactive-State Inhibitor That Demonstrated <i>In Vivo</i> Efficacy. [PDF]

ACS Med Chem Lett
Liang J, Lambrecht MJ, Huestis MP, Zhu B, Barton LM, Castanedo GM, Ung PM, Larouche-Gauthier R, Jakalian A, Leclerc JP, Yadav A, Haghshenas P, Aubert-Nicol S, Ismaili H, Zhao L, Leblanc M, de Almeida H, Wang Q, Garner T, Tan S, Prangley MS, Pang J, Murray JM, Yu C, Hsu PL, Rutz S, Ishizuka I, Huang H, Gao C, Chen M, Mutter-Rottmayer L, Kakiuchi-Kiyota S, Leung DH, Kou P, Bao L, Wang X.   +35 more
europepmc   +1 more source

Design, synthesis, and biological evaluation of novel 3-oxo-2,3-dihydropyridazine derivatives as interleukin-2-inducible T-cell kinase (ITK) inhibitors. [PDF]

RSC Adv
Tangallapalli S, Gundla R, Paidikondala K, Gurská S, Rampeesa NK, Anugu SR, Džubák P, Hajdúch M, Das V, Katari NK.   +9 more
europepmc   +1 more source

Enantioselective Alkyne-Mediated Aldehyde Allylation of Alcohol Proelectrophiles Using RuHCl(CO)(PPh₃)₃ as Precatalyst. [PDF]

Org Lett
Evarts MM, Nguyen TN, Krische MJ.
europepmc   +1 more source

In Situ Construction of Imidazopyridinium Fluorescent Labels for Bioconjugation. [PDF]

Angew Chem Int Ed Engl
Du D, Albert L, Weitzel M, Eijsink LE, Cotroneo ER, Marzin D, Opazo F, Simeth NA.   +7 more
europepmc   +1 more source

Covalent pan-TEAD inhibitors block YAP activity and demonstrate brain penetrance in a Hippo-dependent cancer model. [PDF]

Nat Commun
Hagenbeek TJ, Zbieg J, Smith R, Paul S, Gerosa L, Torrini C, Guarnaccia AD, Ong C, Lacap JA, Ning M, Sodir NM, Hafner M, Tremblay J, Hawley J, Chan B, Verma VA, Beveridge RE, Hsu PL, Ulas G, Wang L, Nonomiya J, Chen S, Pham V, Webster J, Preston J, Hung J, Eastham J, Dunlap D, Lee W, Beroza P, Nayyar N, Martin S, Lin E, Weng J, Foster SA, Shanahan F, Fong R, Boenig G, Di Lello P, Kubala MH, Hunsaker T, Ravichandran M, Saenz-Lopez Larrocha P, Lau J, An L, Levy E, Lorenzo MN, Lill JR, Modrusan ZD, Chen YC, Yao X, Brastianos PK, Maddalo D, Dey A.   +53 more
europepmc   +1 more source

A 5-Azetidinyl BODIPY-Olaparib Conjugate for PARP-Targeted Nuclear and Orthotopic Oral Tumor Imaging. [PDF]

ChemMedChem
Yan K, Qi H, Dong X, Zhao W.
europepmc   +1 more source

Greener deprotection pathways: microwave assisted aqueous deprotection of <i>N</i>-Boc amines. [PDF]

RSC Adv
Vidal-Núñez J, Morales-Guerrero S, Ratjen L, Schott E, Zacconi FC.   +4 more
europepmc   +1 more source