Results 121 to 130 of about 3,171 (179)

Azetidines of pharmacological interest

Archiv der Pharmazie, 2021
AbstractAzetidines are almost unexplored among nitrogen‐containing saturated heterocycles due to difficulties associated with their synthesis. However, over the past few years, attempts have been made by scientists to advance their synthetic feasibility.
Deepa R. Parmar, Jigar Y. Soni, Ramakrishna Guduru, Rahul H. Rayani, Rakesh V. Kusurkar, Anand G. Vala   +5 more
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Synthesis of Azetidines

Journal of Pharmaceutical Sciences, 1971
The synthesis of 3-amino-2-phenylazetidine and the p-chloro analog is reported. The reduction of azetidinones with diborane was investigated and found successful with N-unsubstituted systems. 3-Amino-2-phenylazetidine was found active in vitro against monoamine oxidase.
J N, Wells, O R, Tarwater
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Divergent Functionalizations of Azetidines and Unsaturated Azetidines

Asian Journal of Organic Chemistry, 2019
AbstractAzetidines are unusual heterocyclic motifs that comprise key components of biologically active molecules and provide desirable structural properties for drug discovery. While a variety of methods have been designed for the synthesis of azetidines, screening and optimization studies often require systematic and versatile strategies for varying ...
Tyler W. Reidl, Laura L. Anderson
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Reduction of N-substituted azetidin-2-ones to azetidines

Australian Journal of Chemistry, 1983
Reduction of N-substituted azetidin-2-ones to N-substituted azetidines was accomplished rapidlyand in good yield with diborane in tetrahydrofuran and with alane in ether. The stereochemistryof the ring substituents was retained under the reaction conditions.
MB Jackson, LN Mander, TM Spotswood
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Novel Syntheses of Azetidines and Azetidinones

Chemical Reviews, 2008
2.1.5. Electrophilic Attack on CdC 3994 2.1.6. NH Insertions in Diazo Compounds 3994 2.1.7. Pd Catalyzed Cyclizations 3994 2.2. Cyclizations by C-C Bond formation 3995 2.2.1. Nucleophilic Displacement of Halides 3995 2.2.2. Cyclizations Involving CdO Group 3995 2.3. Cycloadditions 3996 2.4. Ring Rearrangements 3997 2.4.1.
BRANDI, ALBERTO, CICCHI, STEFANO, CORDERO, FRANCA MARIA   +2 more
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Synthesis of 2,2,4,4-tetramethyl-azetidine

Experientia, 1970
La 2, 2,4,4-tetrametil-azetidina (XI), e stata preparata per la prima volta con ottime rese, a partire da 2, 2, 5, 5-tetrametil-3-pirrolidone (I), attraverso i seguenti intermedi: 1-benzoil-2, 2, 5, 5-tetrametil-3-pirrolidone (II), 1-benzoil-2, 2, 5, 5-tetrametil-3, 4-pirrolidindione (III), acido 1-benzoil-3-idrossi-2, 2, 4, 4-tetrametil-3-azetidin ...
L, Dall'Asta, A, Pedrazzoli
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Diastereoselective Preparation of Azetidines and Pyrrolidines

Organic Letters, 2010
Iodine-mediated cyclization of homoallyl amines at room temperature delivered cis-2,4-azetidine through a 4-exo trig cyclization. Isomerization of iodo-azetidines to cis-pyrrolidines could be achieved by heating, with complete stereocontrol. The relative stereochemistry of the iodo-azetidines and pyrrolidines was confirmed by NMR spectroscopy and X-ray
Antonio, Feula, Louise, Male, John S, Fossey   +2 more
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A convenient synthesis of azetidine-2-thiones and azetidin-2-imines

Journal of the Chemical Society, Chemical Communications, 1983
Azetidin-2-iminium salts, which are readily available from tertiary amides, can be easily converted into the corresponding thiones or imines.
Jacqueline Marchand-Brynaert, Manuel Moya-Portuguez, Isabelle Huber, L�on Ghosez   +3 more
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N-substituted azetidines and other aspects of azetidine chemistry

1962
Azetidine has been prepared and its nucleophilicity towards bromoaromatic compounds has been investigated. In this way the synthesis of a number of new N-arylazetidines has been accomplished. The infra red spectra of these azetidines, together with those of a few N-alkylazetidines, prepared from the corresponding 3-aminopropanols, have been compared ...
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A Practical Synthesis of Azetidine

Synthetic Communications, 1988
Abstract A process for the preparation of kilogram quantities of distilled azetidine is described.
David H. Causey, Richard P. Mays, Dwight A. Shamblee, Young S. Lo   +3 more
openaire   +1 more source