Results 111 to 120 of about 1,863 (161)
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Journal of Pharmaceutical Sciences, 1971
The synthesis of 3-amino-2-phenylazetidine and the p-chloro analog is reported. The reduction of azetidinones with diborane was investigated and found successful with N-unsubstituted systems. 3-Amino-2-phenylazetidine was found active in vitro against monoamine oxidase.
J N, Wells, O R, Tarwater
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The synthesis of 3-amino-2-phenylazetidine and the p-chloro analog is reported. The reduction of azetidinones with diborane was investigated and found successful with N-unsubstituted systems. 3-Amino-2-phenylazetidine was found active in vitro against monoamine oxidase.
J N, Wells, O R, Tarwater
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Reduction of N-substituted azetidin-2-ones to azetidines
Australian Journal of Chemistry, 1983Reduction of N-substituted azetidin-2-ones to N-substituted azetidines was accomplished rapidlyand in good yield with diborane in tetrahydrofuran and with alane in ether. The stereochemistryof the ring substituents was retained under the reaction conditions.
MB Jackson, LN Mander, TM Spotswood
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Synthesis of 2,2,4,4-tetramethyl-azetidine
Experientia, 1970La 2, 2,4,4-tetrametil-azetidina (XI), e stata preparata per la prima volta con ottime rese, a partire da 2, 2, 5, 5-tetrametil-3-pirrolidone (I), attraverso i seguenti intermedi: 1-benzoil-2, 2, 5, 5-tetrametil-3-pirrolidone (II), 1-benzoil-2, 2, 5, 5-tetrametil-3, 4-pirrolidindione (III), acido 1-benzoil-3-idrossi-2, 2, 4, 4-tetrametil-3-azetidin ...
L, Dall'Asta, A, Pedrazzoli
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Diastereoselective Preparation of Azetidines and Pyrrolidines
Organic Letters, 2010Iodine-mediated cyclization of homoallyl amines at room temperature delivered cis-2,4-azetidine through a 4-exo trig cyclization. Isomerization of iodo-azetidines to cis-pyrrolidines could be achieved by heating, with complete stereocontrol. The relative stereochemistry of the iodo-azetidines and pyrrolidines was confirmed by NMR spectroscopy and X-ray
Antonio, Feula +2 more
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Novel antibacterial azetidine lincosamides
Bioorganic & Medicinal Chemistry Letters, 2008The synthesis and evaluation of novel azetidine lincosamides 1 are described. Eleven new (3-trans-alkyl)azetidine-2-carboxylic acids were synthesized via alkylation of N-TBS-4-oxo-azetidine-2-carboxylic acid and subsequent elaboration then coupled to 7-chloro-1-methylthio-lincosamine.
Hardwin, O'Dowd +9 more
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A convenient synthesis of azetidine-2-thiones and azetidin-2-imines
Journal of the Chemical Society, Chemical Communications, 1983Azetidin-2-iminium salts, which are readily available from tertiary amides, can be easily converted into the corresponding thiones or imines.
Jacqueline Marchand-Brynaert +3 more
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N-substituted azetidines and other aspects of azetidine chemistry
1962Azetidine has been prepared and its nucleophilicity towards bromoaromatic compounds has been investigated. In this way the synthesis of a number of new N-arylazetidines has been accomplished. The infra red spectra of these azetidines, together with those of a few N-alkylazetidines, prepared from the corresponding 3-aminopropanols, have been compared ...
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A Practical Synthesis of Azetidine
Synthetic Communications, 1988Abstract A process for the preparation of kilogram quantities of distilled azetidine is described.
David H. Causey +3 more
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Four‐Component Strain‐Release‐Driven Synthesis of Functionalized Azetidines
Angewandte Chemie - International Edition, 2022Varinder Aggarwal
exaly