Results 151 to 160 of about 12,849 (199)
Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.A collection of innovative imidazo[1,2‐b]pyrazole–1,2,4‐oxadiazole–1,2,3‐triazole hybrids was conceived via the molecular hybridization of bioactive pharmacophores and produced via a CuAAC methodology. The synthesized compounds exhibited strong antibacterial and antibiofilm properties against gram‐positive bacteria.
Suresh Kumar Murahari, Kavitha Siddoju
wiley +1 more source
Synthesis and Characterization of Polymer-Drug Conjugates by Strain-Promoted Azide-Alkyne Cycloaddition-Mediated Polymerization. [PDF]
J Appl Polym SciGbadegesin OD, Adesina SK.
europepmc +1 more source
Chemistry – A European Journal, Volume 32, Issue 37, 1 October 2026.Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt +3 more
wiley +1 more source
Electrochemical Quantification of miRNA Based on Strain-Promoted Azide-Alkyne Cycloaddition Ligated Tetrahedral DNA Nanotags. [PDF]
Anal ChemMa Y, Wang T, Qu X, Yan R, Miao P.
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Target-Directed Azide-Alkyne Cycloaddition for Assembling HIV-1 TAR RNA Binding Ligands. [PDF]
Angew Chem Int Ed Engl, 2020 Paul R, Dutta D, Paul R, Dash J.
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Peptide Marriages: Modular Assembly of Multi‐Agonist Therapeutics
Chemistry – A European Journal, Volume 32, Issue 37, 1 October 2026.A modular polyethylene glycol (PEG) scaffold enables rapid assembly of dual peptide agonists using strain‐promoted azide–alkyne cycloaddition (SPAAC) and copper‐catalysed azide–alkyne cycloaddition (CuAAC). Glucagon‐like peptide‐1 (GLP‐1) and amylin agonists were combined with controlled valency, yielding low‐picomolar activity and receptor‐selective ...
Kristina A. Kostadinova +11 more
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Author Correction: Ultrasound-assisted Cu(II) Strecker-functionalized organocatalyst for green azide-alkyne cycloaddition and Ullmann reactions. [PDF]
Sci RepAghajani M, Dabiri M.
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Multifunctional Hydrogels: Rational Design and Application in Regenerative Medicine
MedComm, Volume 7, Issue 10, October 2026.Multifunctional hydrogels represent a paradigm shift in regenerative medicine, integrating rational material design with bioactive functionality to address complex tissue repair challenges. This review systematically examines the molecular engineering, structure–function relationships, and translational landscape of advanced hydrogel systems, spanning ...
Linyang Song +4 more
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Bioorthogonal Tools for Ethanolamine Lipids and Protein Conjugates
Angewandte Chemie, Volume 138, Issue 40, 28 September 2026.An alkyne‐tagged ethanolamine analog (AlkEA) enables bioorthogonal, metabolic labeling of endogenous phosphatidylethanolamine (PE) and its protein modifications. AlkEA is incorporated into PE via the Kennedy pathway, allowing CuAAC‐based visualization of PE and affinity capture of PE‐conjugated LC3, ubiquitin, and GPI‐anchored proteins.
Yuan‐Ting Cho +5 more
wiley +2 more sources