Results 171 to 180 of about 28,418 (220)

Effective microwave-assisted approach to 1,2,3-triazolobenzodiazepinones via tandem Ugi reaction/catalyst-free intramolecular azide-alkyne cycloaddition. [PDF]

open access: yesBeilstein J Org Chem, 2021
Mazur MO   +8 more
europepmc   +1 more source

Reactivity of 2<i>H</i>-Azirines in Copper-Catalyzed Azide-Alkyne Cycloaddition Reactions. [PDF]

open access: yesOrg Lett
Janecký L   +5 more
europepmc   +1 more source

Conditional Copper-Catalyzed Azide-Alkyne Cycloaddition by Catalyst Encapsulation. [PDF]

open access: yesAngew Chem Int Ed Engl, 2020
Brevé TG   +7 more
europepmc   +1 more source

Covalent Protein Inhibitors via Tyrosine and Tryptophan Conjugation with Cyclic Imine Mannich Electrophiles

open access: yesAngewandte Chemie, Volume 138, Issue 15, 6 April 2026.
Targeted covalent inhibitors (TCI) containing cyclic imine warheads react with tyrosine and tryptophan residues via the Mannich reaction. These cyclic imine warheads show comparable reaction kinetics to cysteine‐reactive electrophiles commonly used in TCIs.
Sijie Wang   +6 more
wiley   +2 more sources

Harnessing Methyltransferase‐Guided Targeting for Sequence‐Specific Proximity Labeling of DNA

open access: yesAngewandte Chemie, Volume 138, Issue 15, 6 April 2026.
A novel methyltransferase‐mediated approach leveraging rationally designed S‐adenosyl‐L‐methionine (SAM) analogues was developed to achieve sequence‐specific DNA labeling but in proximity to the natural transfer site, addressing key limitations of previously established methods, including ligand instability and methylation‐sensitive labeling.
Xiong Chen   +8 more
wiley   +2 more sources

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