Reductive Methylation: An Alternative to Lysine → Arginine Mutagenesis
Journal of Peptide Science, Volume 32, Issue 7, July 2026.Replacing lysine with arginine, the standard genetic approach to eliminate amine reactivity, alters physicochemical properties and leaves the N terminus unprotected. Here, reductive methylation is characterized as a conservative chemical alternative. Complete dimethylation of human ribonucleases preserves thermostability, protein–protein interaction ...
Oscar J. Molina +4 more
wiley +1 more source
Critical assessment of copper-alginate hydrogel beads as recyclable and heterogeneous catalysts for aqueous azide‒alkyne cycloaddition. [PDF]
Front ChemMoglie Y +3 more
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1,1‐and 1,2‐Diborylalkenes: Preparation and Synthetic Applications
Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.In this review, we highlight recent advances in the synthesis and reactivity of 1,1‐diborylalkenes and 1,2‐diborylalkenes, along with various transformations leading to C‐C, C‐heteroatom, and multicomponent products. By providing a comprehensive and practical resource, this review aims to assist researchers in exploring the synthetic utility of 1,1 and
Jayaram Vankudoth +2 more
wiley +1 more source
Bioactive Polymeric Scaffolds: Multivalent Functionalization by Thermal Azide-Alkyne Cycloaddition with Alkynyl Dicarbamates. [PDF]
BiomacromoleculesTawara MH +6 more
europepmc +1 more source
Chemistry – A European Journal, Volume 32, Issue 23, 16 June 2026.Using kanamycin A as a model target, we developed click‐capture SELEX to identify nucleobase‐modified aptamers capable of binding small molecules in solution. This approach enables flexible incorporation of nucleobase modifications via CuAAC, allowing the chemical properties of the aptamer to be tailored to the target molecule.
Philipp Menke +5 more
wiley +1 more source
Azide-alkyne cycloaddition (click) reaction in biomass-derived solvent Cyrene<sup>TM</sup> under one-pot conditions. [PDF]
Beilstein J Org ChemMedgyesi Z, Mika LT.
europepmc +1 more source
Self‐Immolative Gels: Programmable Degradation Using Self‐Immolative Linkers and Polymers
Chemistry – A European Journal, Volume 32, Issue 23, 16 June 2026.Self‐immolative linkers and polymers undergo bond‐cleaving reaction cascades in response to specific stimuli. Their incorporation into gels can be harnessed to release cargo, induce property changes, or trigger degradation in a highly controlled manner. These functions can be employed in applications such as sensing and drug delivery.
Chuanfeng Li, Elizabeth R. Gillies
wiley +1 more source
Azide-alkyne cycloaddition reactions over cobalt (0) nanoparticles supported on CaTiO<sub>3</sub> perovskite. [PDF]
Sci RepRahimpour E +3 more
europepmc +1 more source
In Conversation With Karl Barry Sharpless
Transformative Chemistry, EarlyView.
Xiao Zhang, Chunlai Tu, Jiajia Dong
wiley +1 more source
European Journal of Organic Chemistry, Volume 29, Issue 23, 16 June 2026.1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer +6 more
wiley +1 more source