Results 151 to 160 of about 210,123 (350)

Dual Nickel/Photoredox‐Catalyzed Regio‐ and Enantioselective Alkenylation of Epoxides

Advanced Science, EarlyView.
Ni/photoredox‐catalyzed stereoconvergent cross‐electrophile coupling of racemic epoxides with alkenyl bromides is described, affording β‐alkenyl products with up to 95% ee, excellent E‐selectivity, and complete regiocontrol. These versatile intermediates enable diverse chiral synthons; mechanistic studies suggest a halide ring‐opening followed by ...
Hongyan Lan, Shengzhou Jin, Zhao‐Dong Xu, Guigen Li, Dingyi Wang   +4 more
wiley   +1 more source

Metal-free click polymerizations of activated azide and alkynes

, 2013
The Cu(i)-catalyzed azide-alkyne click polymerization has become a powerful tool for the preparation of functional polytriazoles. However, copper residues in the products could harm the performance of optoelectronic devices and be cytotoxic in biological
Sun, Jing Zhi, Wang, Jian, Li, Hongkun, Zhang, Xiao A., Wei, Qiang, Qin, Anjun, Wang, Qiang, Tang, Ben Zhong   +7 more
core   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

Symbiotic Characterization of Azide-Resistant Mutants of Rhizobium leguminosarum by trifolii [PDF]

Azide-resistant mutants of Rhizobium legumnosarum bv, trifolii strain NZPS61 were isolated. Mutations conferring azide resistance appeared at a frequency of 1.6x t0·7 on minimal media containing 25 µglml sodium azide. Two classes of mutants were observed
Corner, R, Sharma, Shashi Bhushan, Sakadevan, K   +2 more
core   +1 more source

High-Energetic Salts and Metal Complexes: Comprehensive Overview with a Focus on Use in Homemade Explosives (HME)

Molecules
Metal-containing compounds form a large and rapidly expanding group of high-energy materials. Many compounds in this class attract the attention of non-professionals, who may attempt the illegal production of explosives.
Błażej Gierczyk, Maciej Zalas, Tomasz Otłowski   +2 more
doaj   +1 more source

Spin trapping of the azide radical with nitroso compounds

, 1982
Azide radicals (N3·) are formed in aqueous solutions by the reaction of hydroxyl radicals (·OH) with azide anions (N3aq−). Azide radicals have been spin trapped with three nitroso spin traps: nitrosodurene (ND), 2,6-dideutero-3,5-dibromo-4 ...
Ajit Singh, Walter Kremers, Grant W Koroll   +2 more
core   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source

Functionalization of polyfluorene-wrapped carbon nanotubes via copper-mediated azide–alkyne cycloaddition

, 2018
Copper-mediated azide–alkyne cycloaddition enables quantitative functionalization of polymer-nanotube complexes containing azide moieties in the polymer side chains.
Darryl Fong, Grace M. Andrews, Alex Adronov   +2 more
core   +1 more source

Sequential Patterning of Photoresponsive Hydrogels Directs Crypt Fission and Reveals the Role of Epithelial Curvature on Fission Symmetry

Advanced Science, EarlyView.
Deterministic crypt fission is achieved in intestinal organoids using photopatternable hydrogels with spatiotemporal control. Daughter‐crypt symmetry is shown to depend on parent‐crypt geometry and epithelial curvature, while myosin‐dependent mechanosensing links tissue shape to regenerative outcomes.
Delaney L. McNally, Kaustav Bera, Nolan R. Petrich, Alex Khang, Marilyne Coulombe, David Castillo‐Azofeifa, Ophir D. Klein, Peter J. Dempsey, Kristi S. Anseth   +8 more
wiley   +1 more source

Mesenchymal Stromal Cell‐Based Cell–Drug Conjugates for the Treatment of Acute Liver Failure

Advanced Science, EarlyView.
Mesenchymal stromal cell (MSC)‐based cell‐drug conjugates are constructed by anchoring rosiglitazone‐loaded nanoparticles onto the MSC surface. Sustained rosiglitazone release enhances MSC proliferation and paracrine activity while promoting anti‐inflammatory macrophage polarization.
Tenghui Ye, Jiamin Wu, Zixin Wu, Xi Liu, Jiajia Luo, Leyi Yang, Peng Shi   +6 more
wiley   +1 more source