Results 171 to 180 of about 227,214 (300)

Organic Azides. 3. Ultrasound Synthesis of Propargyl Azide, Azidoacetonitrile and Primary Allylic Azides. [PDF]

Acta Chemica Scandinavica, 1984
Hanno Priebe, Gunner Borch, Synnøve Liaaen-Jensen, Anders Måhlén, Lars Mörch   +4 more
openaire   +1 more source

A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase

Angewandte Chemie International Edition, EarlyView.
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne, Jonathan Pettinger, Teresa Weckwerth, Andrew Purkiss, Sing Hei Lok, Louisa Penicaut, Roksana Ogrodowicz, Raveena Prema, Simone Kunzelmann, Chloe Roustan, Ganka Bineva‐Todd, Saskia Pieters, Francesca Zappacosta, Alfred E. Doherty, Isobel Oram, Christelle Soudy, Robert Quinlan, Joanna Redmond, Svend Kjaer, David House, Stephane Mouilleron, Jacob T. Bush, Benjamin Schumann   +22 more
wiley   +1 more source

On-DNA Platform Molecules Based on a Diazide Scaffold II: A Compact Diazide Platform Designed for Small-Molecule Drug Discovery. [PDF]

Int J Mol Sci
Miyachi H, Koshimizu M, Suzuki M.
europepmc   +1 more source

Single-cell heterotrophic activity in deep-ocean prokaryotic communities quantified by BONCAT and microautoradiography. [PDF]

ISME Commun
Amano C, Sintes E, Lebon N, Steiger J, Prijovic D, Reinthaler T, Obernosterer I, Bergauer K, Herndl GJ.   +8 more
europepmc   +1 more source

Ribozymes for RNA‐Catalyzed RNA Methylation and Labeling

Angewandte Chemie International Edition, EarlyView.
Ribozymes are powerful tools for site‐specific RNA modification. Their activities range from installing tags and fluorophores to generating natural RNA methylations, making them valuable tools to uncover the many functions that RNA plays in nature.
Carolin P. M. Scheitl, Claudia Höbartner   +1 more
wiley   +1 more source

The Copper-Catalyzed Azide-Alkyne Cycloaddition Reaction: Why Two Is Faster than One. [PDF]

Chemphyschem
Vermeeren P.
europepmc   +1 more source

Nano‐Gs Protein Peptidomimetics: Rational Design of Gα C‐Terminus‐Derived Peptides Mimicking Key Components of Gs‐β2AR Interactions

Angewandte Chemie International Edition, EarlyView.
G protein‐coupled receptors (GPCRs) are major therapeutic targets. Modulating GPCR activity through intracellular sites is evolving. A structure‐ and computation‐assisted approach generated small G protein‐derived peptidomimetics targeting the intracellular binding crevice of the β2 adrenergic receptor mimicking features of the full G protein.
Phuong Thu Tran, Mia Danielsen, Johanna K. S. Tiemann, Passainte Ibrahim, Søren G. F. Rasmussen, Xavier Kubiak, Hossein Batebi, Charlène Gadais, Steven Ballet, Peter W. Hildebrand, Daniel Sejer Pedersen, Jesper Mosolff Mathiesen   +11 more
wiley   +1 more source

Enabling the synthesis of multi-payload thio-antibody conjugates through the use of pyridazinediones, <i>p</i>-anisidine derivatives and various click chemistries. [PDF]

RSC Chem Biol
McMahon C, Queval CJ, Thanasi IA, Lau DHW, Howell M, Wang N, Lee MTW, Gaynord JS, Baker JR, Chudasama V.   +9 more
europepmc   +1 more source

Synthesis of [¹⁸F]rufinamide as a radiotracer for epileptic brain imaging. [PDF]

RSC Adv
Pandey V, Faheem M, Gambhir S, Dixit M.
europepmc   +1 more source

Azide-Engineered Nanocrystals Enable Direct Grafting of Conjugated Polymers via Click Chemistry. [PDF]

ACS Omega
Jin W, Jung J.
europepmc   +1 more source