Results 171 to 180 of about 152,508 (309)

Bioorthogonal Click Chemistry Enables Stable Cell Attachment to Silk Fibroin Scaffolds for Tissue Engineering Applications: Proof of Concept in Neural Regeneration. [PDF]

Biomacromolecules
Quintana-Prego A, Guedan-Duran A, Guinea GV, Gomez-Rivas J, Panetsos F.   +4 more
europepmc   +1 more source

Sequential Patterning of Photoresponsive Hydrogels Directs Crypt Fission and Reveals the Role of Epithelial Curvature on Fission Symmetry

Advanced Science, EarlyView.
Deterministic crypt fission is achieved in intestinal organoids using photopatternable hydrogels with spatiotemporal control. Daughter‐crypt symmetry is shown to depend on parent‐crypt geometry and epithelial curvature, while myosin‐dependent mechanosensing links tissue shape to regenerative outcomes.
Delaney L. McNally, Kaustav Bera, Nolan R. Petrich, Alex Khang, Marilyne Coulombe, David Castillo‐Azofeifa, Ophir D. Klein, Peter J. Dempsey, Kristi S. Anseth   +8 more
wiley   +1 more source

A Water-Soluble Fluorogenic Probe to Quantify Azide Concentrations in Biologically Relevant Environments. [PDF]

Biomacromolecules
Gerrits L, Verdellen L, Peeters M, Gelderman A, Gross UJ, Shaghaghi B, Hammink R, Kouwer PHJ.   +7 more
europepmc   +1 more source

Mesenchymal Stromal Cell‐Based Cell–Drug Conjugates for the Treatment of Acute Liver Failure

Advanced Science, EarlyView.
Mesenchymal stromal cell (MSC)‐based cell‐drug conjugates are constructed by anchoring rosiglitazone‐loaded nanoparticles onto the MSC surface. Sustained rosiglitazone release enhances MSC proliferation and paracrine activity while promoting anti‐inflammatory macrophage polarization.
Tenghui Ye, Jiamin Wu, Zixin Wu, Xi Liu, Jiajia Luo, Leyi Yang, Peng Shi   +6 more
wiley   +1 more source

Assembly-formed bioorthogonal chimeric artificial receptors enable high-contrast fluorescence imaging of tumors. [PDF]

Sci Adv
Zuo J, Tan Y, Mu Z, Dong Y, Wu Y, Li Y, Yuan Y, Wang X, Dang Y, Bai L, Liang H.   +10 more
europepmc   +1 more source

Development of a Safe and Efficient Alkyl Azide Synthesis using Arylsulfonyl Azide

, 2010
x, 115 leaves : ill. ; 29 cm.Sodium azide has traditionally been used as the source of azide anion for the synthesis of alkyl azides. Besides difficulties with solubility, sodium azide is toxic, can be absorbed through the skin, and forms potentially ...
Okumu, Antony
core  

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Synthesis of Macrocyclic Structures by Intramolecular Photoclick Reaction. [PDF]

J Am Chem Soc
Sharma S, Foster P, Molnar C, Badenhorst R, Minko S, Popik VV.   +5 more
europepmc   +1 more source

Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma

Advanced Science, EarlyView.
SOX2 upregulates KAT7 in glioma stem cells, where KAT7 deposits H3K14 acetylation at the RAC2 promoter to activate RAC2 transcription. RAC2‐GTP subsequently promotes PAK1/2/3 phosphorylation, increasing tricarboxylic acid cycle flux and mitochondrial respiration to support glioblastoma malignancy.
Jilong Liu, Yanfei Sun, Yuehua Zhu, Guangjing Mu, Jiazheng Wang, Liangliang Wang, Feihu Zhao, Zhimin Zhao, Jian Wang, Ying He, Zheng Jiang, Xingang Li, Mingzhi Han, Bin Huang   +13 more
wiley   +1 more source

Tailoring stimuli-responsive copolymers <i>via</i> a universal poly(glycidyl methacrylate) modification strategy. [PDF]

RSC Adv
Heinz S, Glößner V, Gallei M.
europepmc   +1 more source