Results 61 to 70 of about 210,123 (350)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

4-[4-(Azidomethyl)phenyl]-2,6-diphenylpyridine

IUCrData, 2019
The title compound, C24H18N4, crystallizes with three molecules in the asymmetric unit. In the crystal, weak C—H...π interactions link the molecules.
Xingwang Cheng, Yanan Du, Hui Guo, Zhiyuan Chen, Yupeng Tian   +4 more
doaj   +1 more source

Coexistence of Spin Canting and Metamagnetism in a One-Dimensional Mn(II) Compound Bridged by Alternating Double End-to-End and Double End-On Azido Ligands and the Analog Co(II) Compound

Magnetochemistry, 2021
Two new compounds of general formula [M(N3)2(dmbpy)] in which dmbpy = 5,5′-dimethyl-2,2′-bipyridine, and M = Mn(II) or Co(II), have been solvothermally synthesized and characterized structurally and magnetically.
Nesrine Benamara, Zouaoui Setifi, Chen-I Yang, Sylvain Bernès, David K. Geiger, Güneş Süheyla Kürkçüoğlu, Fatima Setifi, Jan Reedijk   +7 more
doaj   +1 more source

Tests of the Azide Method to Measure Nitrite N and O isotope ratios

, 2019
Experiments demonstrating matrix effects (sample salinity and pH) on nitrite N and O isotope ratio measurements with the azide method of McIlvin and Altabet (2005, doi:10.1021/ac050528s)
Böhlke, John Karl, Chen, Nengwang, Danielle S Boshers (7885727), Granger, Julie, Tobias, Craig R, Craig R Tobias (7885730), Julie Granger (7885724), Dan Yu (214174), Yu, Dan, John Karl Böhlke (2438818), Nengwang Chen (5211467), Boshers, Danielle S   +11 more
core   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Electrochemical vicinal oxyazidation of α-arylvinyl acetates

Beilstein Journal of Organic Chemistry, 2022
α-Azidoketones are valuable and versatile building blocks in the synthesis of various bioactive small molecules. Herein, we describe an environmentally friendly and efficient electrochemical vicinal oxyazidation protocol of α-arylvinyl acetates to afford
Yi-Lun Li, Zhaojiang Shi, Tao Shen, Ke-Yin Ye   +3 more
doaj   +1 more source

s-Triazine: A Privileged Structure for Drug Discovery and Bioconjugation

Molecules, 2021
This review provides an overview of the broad applicability of s-triazine. Our many years working with this intriguing moiety allow us to discuss its wide activity spectrum (inhibition against MAO-A and -B, anticancer/antiproliferative and antimicrobial ...
Anamika Sharma, Rotimi Sheyi, Beatriz G. de la Torre, Ayman El-Faham, Fernando Albericio   +4 more
doaj   +1 more source

azides [PDF]

, 2008
Citation: 'azides' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.A00555 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Synthesis of 4‑Tetrazolyl-Substituted 3,4-Dihydroquinazoline Derivatives with Anticancer Activity via a One-Pot Sequential Ugi-Azide/Palladium-Catalyzed Azide-Isocyanide Cross-Coupling/Cyclization Reaction

, 2022
A new one-pot preparation of 4-tetrazolyl-3,4-dihydroquinazolines has been reported. The Ugi-azide reactions of 2-azidobenzaldehydes, amines, trimethylsilyl azide, and isocyanides produced azide intermediates without separation, which were treated with ...
Zhi-Gang Zeng (847687), He-Yu Yang (13157127), Yong-Long Pang (13157139), Bo Hu (126105), Hui-Ting He (13157124), Jun Xiong (1315680), Yuan-Yuan Tao (13157136), Hai-Li Zhu (203802), Cheng-Ran Zhong (13157130), Xiao-Lei Miao (13157148), Meng-Ling Ouyang (13157133), Gang Yao (31248), Zi-Xiang Fu (13157145), Hang Shi (120167), Yang-Hong Zhang (13157142)   +14 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source