Results 1 to 10 of about 3,434 (226)

Triethylamine-Promoted Oxidative Cyclodimerization of 2H-Azirine-2-carboxylates to Pyrimidine-4,6-dicarboxylates: Experimental and DFT Study [PDF]

Molecules, 2023
An unprecedented oxidative cyclodimerization reaction of 2H-azirine-2-carboxylates to pyrimidine-4,6-dicarboxylates under heating with triethylamine in air is described. In this reaction, one azirine molecule undergoes formal cleavage across the C-C bond
Timofei N. Zakharov, Pavel A. Sakharov, Mikhail S. Novikov, Alexander F. Khlebnikov, Nikolai V. Rostovskii   +4 more
doaj   +3 more sources

5-Chloroisoxazoles: A Versatile Starting Material for the Preparation of Amides, Anhydrides, Esters, and Thioesters of 2H-Azirine-2-carboxylic Acids [PDF]

Molecules, 2022
Amides, anhydrides, esters, and thioesters of 2H-azirine-2-carboxylic acids were prepared by a rapid procedure at room temperature involving FeCl2-catalyzed isomerization of 5-chloroisoxazoles to 2H-azirine-2-carbonyl chlorides, followed by reaction with
Anastasiya V. Agafonova, Mikhail S. Novikov, Alexander F. Khlebnikov   +2 more
doaj   +3 more sources

Synthesis of 2H-azirine-2,2-dicarboxylic acids and their derivatives [PDF]

Beilstein Journal of Organic Chemistry
Methods for the preparation of 3-aryl-2H-azirine-2,2-dicarboxylic acids and their amides, esters, and azides by FeCl2-catalyzed isomerization of 3-aryl-5-chloroisoxazole-4-carbonyl chlorides into 3-aryl-2H-azirine-2,2-dicarbonyl dichlorides followed by ...
Anastasiya V. Agafonova, Mikhail S. Novikov, Alexander F. Khlebnikov   +2 more
doaj   +3 more sources

Acridine–Isoxazole and Acridine–Azirine Hybrids: Synthesis, Photochemical Transformations in the UV/Visible Radiation Boundary Region, and Anticancer Activity [PDF]

Molecules
Easy-to-handle N-hydroxyacridinecarbimidoyl chloride hydrochlorides were synthesized as convenient nitrile oxide precursors in the preparation of 3-(acridin-9/2-yl)isoxazole derivatives via 1,3-dipolar cycloaddition with terminal alkynes, 1,1 ...
Ekaterina E. Galenko, Mikhail S. Novikov, Alexander S. Bunev, Alexander F. Khlebnikov   +3 more
doaj   +3 more sources

Azirinyl-Substituted Nitrile Oxides: Generation and Use in the Synthesis of Isoxazole Containing Heterocyclic Hybrids [PDF]

Molecules
The procedure for the generation of azirinyl-substituted nitrile oxides by the reaction of 2-(diazoacetyl)-2H-azirines with tert-butyl nitrite while preserving the azirine ring has been developed.
Alexander S. Dudik, Timur O. Zanakhov, Ekaterina E. Galenko, Mikhail S. Novikov, Alexander F. Khlebnikov   +4 more
doaj   +2 more sources

3-Aryl-2H-azirines as annulation reagents in the Ni(II)-catalyzed synthesis of 1H-benzo[4,5]thieno[3,2-b]pyrroles [PDF]

Beilstein Journal of Organic Chemistry
A high-yielding method for the synthesis of 3-arylbenzo[4,5]thieno[3,2-b]pyrroles has been developed via pyrrole ring annulation to the aromatic benzo[b]thiophene system, using 3-arylazirines as a N‒C=C synthon.
Julia I. Pavlenko, Pavel A. Sakharov, Anastasiya V. Agafonova, Derenik A. Isadzhanyan, Alexander F. Khlebnikov, Mikhail S. Novikov   +5 more
doaj   +2 more sources

3-Amino-2H-azirine, Moleküle mit vielfältigen Reaktionsmöglichkeiten [PDF]

CHIMIA, 1979
3-Amino-2H-azirines, cyclic three-membered amidines with an estimated ring strain of about 200 kJ/mole, undergo a variety of reactions. Thereby, each of the azirine bonds can be broken: Thermolysis leads to the rupture of the C(2),C(3)-bond, with strong
Heinz Heimgartner
doaj   +3 more sources

Copper(II)-Catalyzed (3+2) Cycloaddition of 2H-Azirines to Six-Membered Cyclic Enols as a Route to Pyrrolo[3,2-c]quinolone, Chromeno[3,4-b]pyrrole, and Naphtho[1,8-ef]indole Scaffolds [PDF]

Molecules, 2022
A method for the [2+3] pyrroline annulation to the six-membered non-aromatic enols using 3-aryl-2H-azirines as annulation agents is developed in the current study.
Pavel A. Sakharov, Nikolai V. Rostovskii, Alexander F. Khlebnikov, Mikhail S. Novikov   +3 more
doaj   +2 more sources

Non-Aziridination Approaches to 3-Arylaziridine-2-carboxylic Acid Derivatives and 3-Aryl-(aziridin-2-yl)ketones. [PDF]

Int J Mol Sci, 2022
Funding Information: APC was covered by Riga Stradins University, Riga, Latvia. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Highly functionalized aziridines, including compounds with aromatic moieties, are attractive ...
Strumfs B, Velikijs K, Uljanovs R, Sinkarevs S, Strumfa I.   +4 more
europepmc   +3 more sources

2H-Azirines as electrophiles [PDF]

, 2011
2H-Azirines have shown an unusual potential to synthesise aziridines and other types of compounds. Many functionalized aziridines can be produced by addition of O-, S-,N-, C-nucleophiles and hydride to 2H-azirines.
Alves, M. José, Costa, Flora Teixeira e
core   +2 more sources