Results 171 to 180 of about 15,577 (237)

An Evaluation of Foreign Clinical Data in the Approval Reviews of Antimicrobial Medicines in Japan: Considering Ethnic and Regional Differences in Data Extrapolations in Accordance With Regulatory Circumstances

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT The approval requirements in new regions that do not require domestic clinical data and the clinical data evaluation of multi‐regional clinical trials (MRCTs) and foreign clinical trials (FCTs) in the Japanese approval review processes for antimicrobial medicines were explored.
Rumiko Shimazawa, Masayuki Ikeda
wiley   +1 more source

Diagnostic and Therapeutic Dilemmas in Recurrent Pulmonary Alveolar Proteinosis After Bilateral Lung Transplantation

open access: yesRespirology Case Reports, Volume 14, Issue 6, June 2026.
Pulmonary alveolar proteinosis (PAP) is an ultra‐rare lung disease that can recur even years after bilateral lung transplantation, as in this 73‐year‐old man whose diagnosis was delayed by PAS‐negative BAL and overlapping opportunistic infections (Nocardia, MAC, Aspergillus). Despite initially normal post‐transplant spirometry, he developed progressive
Omar Lopez   +3 more
wiley   +1 more source

Novel Therapeutics for Chronic Obstructive Pulmonary Disease: From Empirical Bronchodilation to Precision Medicine

open access: yesRespirology, Volume 31, Issue 6, Page 561-577, June 2026.
ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley   +1 more source

Real‐World Patient Characteristics and Treatment Patterns Among Patients With Interstitial Cystitis (IC)/Bladder Pain Syndrome (BPS)

open access: yesReproductive, Female and Child Health, Volume 5, Issue 2, June 2026.
ABSTRACT Objective Interstitial cystitis/bladder pain syndrome (IC/BPS) is linked to bladder and/or pelvic pain, pressure, and discomfort with urinary frequency. Despite guidelines, there is a need for better treatment options. This study analyzed patient demographics, clinical characteristics, and treatment patterns for medications and procedures in ...
Jaromir Mikl   +8 more
wiley   +1 more source

Guide for Teachers and Schools / Guía del Maestro y su Esquela [PDF]

open access: yes, 2004
Benguigui, Y, Drasbek, C, Chico, RM
core  

Nonparametric Tests for Treatment Effect Leveraging Information on Recurrent and Terminal Events and Physiological Decline

open access: yesStatistics in Medicine, Volume 45, Issue 13-14, June 2026.
ABSTRACT When evaluating treatment effects in progressive disease clinical trials, analyses of time to recurrent or terminal events largely ignore (or separately analyze) functional measures of disease progression over time. For instance, in pulmonary research settings, treatment may impact recurrent times‐to‐hospitalization, mortality and pulmonary ...
Lantian Xu, Susan Murray
wiley   +1 more source

Exposure to Systemic Antimicrobials During Pregnancy and Risk of Miscarriage: A Population‐Based Registry Study

open access: yesBJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 7, Page 1394-1404, June 2026.
ABSTRACT Objective To estimate miscarriage risk following gestational antimicrobial exposure while addressing biases that have affected previous studies. Design Population‐based cohort study. Setting Linkage of four nationwide registries: Medical Birth Registry of Norway (MBRN), Norwegian Prescribed Drug Registry (NorPD), Norwegian Patient Registry ...
Thomas Boissiere‐O'Neill   +3 more
wiley   +1 more source

Reactive Infectious Mucocutaneous Eruption (RIME): An Australian Case Series

open access: yesAustralasian Journal of Dermatology, Volume 67, Issue 4, Page 241-246, June 2026.
ABSTRACT Whilst Reactive Infectious Mucocutaneous Eruption (RIME) displays a low mortality rate, the condition results in significant morbidity and resource allocation, including prolonged hospital admission. As such, early diagnosis and optimisation of treatment is imperative.
Hamish Moore   +2 more
wiley   +1 more source

Trueness of Dental Implant Placement Using Dynamic Navigation or Non‐Guided Approach by Novice Surgeons: A Randomized, Controlled Clinical Trial

open access: yesClinical Oral Implants Research, Volume 37, Issue 6, Page 770-782, June 2026.
ABSTRACT Objectives To compare the trueness of implant placement in novice surgeons using dynamic computer‐assisted implant surgery (d‐CAIS) versus a non‐guided approach, assessing surgery time efficiency and patient‐reported outcomes, including satisfaction, postoperative pain, and quality of life. Material and Methods A double‐arm randomized clinical
Víctor Ruiz‐Romero   +5 more
wiley   +1 more source

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