Results 61 to 70 of about 96,342 (294)

Should azithromycin be used to treat COVID-19? A rapid review

BJGP Open, 2020
Background: There are no established effective treatments for COVID-19. While novel drugs are being developed, azithromycin has been identified as a candidate treatment in the interim.
Kome Gbinigie, Kerstin Frie
doaj   +1 more source

Selection of Macrolide and Non-Macrolide Resistance with Mass Azithromycin Distribution: A Community-Randomized Trial

New England Journal of Medicine, 2020
Background Biannual mass azithromycin distributions to preschool children for 2 years have been shown to reduce childhood mortality in sub-Saharan Africa, but at the cost of amplifying macrolide resistance.
T. Doan, L. Worden, Armin Hinterwirth, Ahmed M. Arzika, Ramatou Maliki, Amza Abdou, Lina Zhong, Cindi Chen, Catherine A. Cook, E. Lebas, Kieran S. O’Brien, C. Oldenburg, E. Chow, T. Porco, M. Lipsitch, J. Keenan, T. Lietman   +16 more
semanticscholar   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Supra and subgingival application of antiseptics or antibiotics during periodontal therapy

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient ...
Elena Figuero, Jorge Serrano, Nicole Birgit Arweiler, Thorsten Mathias Auschill, Ali Gürkan, Gülnur Emingil   +5 more
wiley   +1 more source

Cardiovascular Toxicities Associated With Hydroxychloroquine and Azithromycin

Circulation, 2020
Keywords: azithromycin;cardiotoxicity;hydroxychloroquine;phamacovigilance EN azithromycin cardiotoxicity hydroxychloroquine phamacovigilance 303 305 3 07/23/20 20200721 NES 200721 Although hydroxychloroquine and azithromycin, alone or in combination ...
L. Nguyen, C. Dolladille, M. Drici, C. Fenioux, J. Alexandre, J. Mira, J. Moslehi, D. Roden, C. Funck-Brentano, J. Salem   +9 more
semanticscholar   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

British Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun, Jingrong Yang, Lei Wan, Xia Xu, Jing Wang   +4 more
wiley   +1 more source

Resistance-guided antimicrobial therapy using doxycycline-moxifloxacin and doxycycline-2.5g azithromycin for the treatment of Mycoplasma genitalium infection: efficacy and tolerability.

Clinical Infectious Diseases, 2020
BACKGROUND Macrolide-resistance in Mycoplasma genitalium (MG) exceeds 50% in many regions and quinolone-resistance is increasing. We recently reported that resistance-guided therapy (RGT) using doxycycline followed by sitafloxacin or 2.5g-azithromycin ...
Duygu Durukan, T. Read, G. Murray, Michelle Doyle, E. Chow, L. Vodstrcil, C. Fairley, I. Aguirre, E. Mokany, L. Tan, Marcus Y. Chen, C. Bradshaw   +11 more
semanticscholar   +1 more source

Root coverage using a microsurfaced acellular dermal matrix: A retrospective case series

Clinical Advances in Periodontics, EarlyView.
Abstract Background Acellular dermal matrices (ADMs) have been used for root coverage for over 25 years, yet few advancements have improved clinical outcomes or reduced complications. This case series evaluated the use of a novel microsurfaced ADM (mADM), which features a microtextured surface designed intended to promote healing and improve graft ...
Yu‐Chang Wu, Guo‐Liang Cheng, Shaun Rotenberg   +2 more
wiley   +1 more source

Sub-MICs of Azithromycin Decrease Biofilm Formation of S. suis and Increase Capsular Polysaccharide Content of S. suis

Frontiers in Microbiology, 2016
S. suis (Streptococcus suis) caused serious disease symptoms in humans and pigs. S. suis is able to form thick biofilms and this increases the difficulty of treatment.
Yanbei Yang, Jianqing Chen, Yulin Zhao, Jing-Wen Bai, Wen-Ya Ding, Yonghui Zhou, Xue-Ying Chen, Di Liu, YanHua Li   +8 more
doaj   +1 more source

Synthesis and Glycosidase Inhibition Studies of Novel Exoglycals Targeting GH3 Family Enzymes: Insights from Comparative Analysis with Macrolide Antibiotics

Chemistry – A European Journal, EarlyView.
A series of structurally diverse exoglycals was synthesized using a modified Julia‐olefination approach from sugar‐derived precursors. These glycosidase transition‐state mimics were further diversified via CuAAC chemistry to yield triazole‐conjugated analogues.
Elisa Ospanow, Oscar L. Alferez, David L. Jakeman   +2 more
wiley   +1 more source