Results 71 to 80 of about 63,105 (214)

Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation

Respiratory Research, 2017
Background Azithromycin, an antibiotic used for multiple infectious disorders, exhibits anti-inflammatory effects, but the molecular basis for this activity is not well characterized.
Elizabeth A. Lendermon, Tiffany A. Coon, Joseph S. Bednash, Nathaniel M. Weathington, John F. McDyer, Rama K. Mallampalli   +5 more
doaj   +1 more source

Frontline Healthcare Professionals' Perceptions of the Duty to Care During the COVID‐19 Pandemic: A Multi‐Method Study in Mozambique

Developing World Bioethics, EarlyView.
ABSTRACT COVID‐19 intensified ethical tensions between clinicians' duty to care and self‐protection amid PPE shortages. We explored frontline healthcare professionals' perspectives in Maputo, Mozambique. Semi‐structured interviews with healthcare professionals at four hospitals (April–June 2022) were recorded in Portuguese, transcribed, and ...
Ângela Alface, Graça Salomé, Khátia Munguambe, Troy D. Moon, Esperança Sevene, Elizabeth Heitman   +5 more
wiley   +1 more source

A case of clinical and microbiological failure of azithromycin therapy in Salmonella enterica serotype Typhi despite low azithromycin MIC

International Journal of Infectious Diseases, 2017
Typhoid fever remains a serious problem in many developing countries. Due to resistance to multiple first line drugs, azithromycin has evolved as an important drug in the treatment of typhoid.
Abi Manesh, Veeraraghavan Balaji, Devanga Ragupathi Naveen Kumar, Priscilla Rupali   +3 more
doaj   +1 more source

Structure of AI Responses With Complex Patient Analysis for Patient Alternatives and Patient Modifiers

European Journal of Dental Education, EarlyView.
ABSTRACT Background Artificial intelligence (AI) is already a powerful tool that is rapidly growing within the dental sector. Reports of structure and characteristics of AI responses to patient scenarios are limited. Purpose To analyse characteristics and structure of AI responses to prompts for treatment planning alternatives and patient alternatives ...
David C Johnsen, Leonardo Marchini, Kim Vo, L Brendan Young, Shareef M Dabdoub   +4 more
wiley   +1 more source

Phase IIB, Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial of Intravenous Defibrotide for the Prevention and Treatment of Respiratory Distress and Cytokine Release Syndrome in COVID‐19

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Endothelial dysfunction is key in COVID‐19 pathogenesis. This randomized, double‐blind phase IIb trial investigated continuous intravenous infusion of defibrotide in patients hospitalized with SARS‐CoV‐2 infection and respiratory failure.
Ruben Jara Rubio, Antonio José Martinez‐Mellado, Jonathan Kiwitt‐Cárdenas, José G. Clavel, Bartolomé García‐Perez, Pedro Castro, Maribel Diaz‐Ricart, Andrés Carrillo‐Alcaraz, Amparo López‐Bernús, Enrique Bernal Morell, Aychel Roura, Sonia Marín, Francisco‐José Ruiz‐López, Elena Solana‐Martinez, Domingo Martinez‐Baño, Carlos L. Albacete Moreno, Enriqueta Andreu Soler, Adrián Tellez Santoyo, Sara Fernández Méndez, Jose A. Noguera Velasco, Iria Cebreiros Lopez, Andrés Parrilla, Alberto Espuny‐Miró, David García‐Bernal, Miguel Blanquer, Andrés Sánchez‐Salinas, Francisca Iniesta, Cristina Hernandez Garcia, Manuel Muro, Alfredo Minguela Puras, Antonio Moreno‐Docón, Alberto M. Torres‐Cantero, Maria Munoz Garcia, Manuel Serrano, Massimo Iacobelli, Carmelo Carlo‐Stella, Lee‐Jen Wei, Paul G. Richardson, José M. Moraleda   +38 more
wiley   +1 more source

Aptamer‐mediated outer membrane destabilization overcomes low permeability resistance in Pseudomonas aeruginosa

The FEBS Journal, EarlyView.
DNA aptamers, Apt 60 and Apt 173, target the BamA protein to compromise outer membrane integrity in Pseudomonas aeruginosa, making it susceptible to Azithromycin, an antibiotic that is otherwise poorly effective due to the low‐permeability membrane.
Rupany Selvam, Michelle Khai Khun Yap, Rafael Giacomazzi, Sérgio F. Sousa, Hock Siew Tan   +4 more
wiley   +1 more source

Clinical Effects of Traditional Chinese Medicine + Azithromycin in the Treatment of Mycoplasma Pneumonia

International Journal of General Medicine
Guan Zhang,1 Qian Li,2 Jing Zhang1 1Department of Infection, Taihe County Hospital of Traditional Chinese Medicine, Buyang City, Anhui Province, 236600, People’s Republic of China; 2Department of Pharmacy, Taihe County Hospital of Traditional Chinese ...
Zhang G, Li Q, Zhang J
doaj  

Azithromycin use before and during the COVID- 19 pandemic and the impact of implementing national evidence-based guidelines in Qatar

Clinical Epidemiology and Global Health
Background: Initial small, uncontrolled studies suggested a beneficial effect of azithromycin in individuals with COVID-19. However, subsequent studies have not confirmed its effectiveness. We assessed azithromycin usage before and during the pandemic in
Adeel A. Butt, Sherin Shams, Hanaa Nafady-Hego, Zain Bhutta, Atika Jabeen, Aimon B. Malik, Anil G. Thomas, Samah Saleem, Aftab M. Azad, Muna Almaslamani, Abdullatif Alkhal, Abdul-Badi Abou-Samra   +11 more
doaj   +1 more source

Legionella pneumophila pneumonia in South Eastern Sydney: diagnosis, prognosis and public health outcomes

Internal Medicine Journal, EarlyView.
Abstract Background Legionellosis causes more severe disease than other aetiologies of community‐acquired pneumonia (CAP). Early recognition and treatment of Legionella pneumonia reduce mortality. Urinary antigen testing (UAT) has facilitated rapid and reliable diagnosis of Legionella pneumonia. Aims The aims of this study were as follows: (i) identify
Sue Qian, Nickson Ning, Kelli Snyders, Misha Klingstrom, Pam Konecny, Vicky Sheppeard, Rachael Roberts, Georgia Shimmin, Robert Stevens, Richard Sullivan   +9 more
wiley   +1 more source

Longitudinal lung function trajectories in response to azithromycin therapy for chronic lung disease in children with HIV infection: a secondary analysis of the BREATHE trial

BMC Pulmonary Medicine
Background Chronic lung disease (CLD) is common among children with HIV (CWH) including in those taking antiretroviral therapy (ART). Azithromycin has both antimicrobial and anti-inflammatory effects and has been effective in improving lung function in a
Tafadzwa Madanhire, Grace McHugh, Victoria Simms, Lucky Ngwira, Carmen Gonzalez-Martinez, Robina Semphere, Brewster Moyo, Claire Calderwood, Mark Nicol, Tsitsi Bandason, Jon O. Odland, Andrea M. Rehman, Rashida A. Ferrand   +12 more
doaj   +1 more source