Results 101 to 110 of about 7,788 (240)

Control of Gemcitabine Activity With Blue and Red Light

Chemistry – A European Journal, EarlyView.
Treating cancer with chemotherapy is generally associated with many side effects, which can be addressed by selectively releasing the desired drugs with visible light. Sixteen new blue light‐activatable cytostatics were introduced, with the gemcitabine derivative exhibiting ideal properties.
Nils F. Kersten, Konstantin L. Stock, Marius Hyprath, Hannah Weisser, Timo Weinrich, Dieter Steinhilber, Alexander Heckel   +6 more
wiley   +1 more source

Semi-automated screening of azobezenes for solar energy storage using extended tight binding methods

Scientific Reports
In the face of the pressing climate change crisis, Molecular Solar Thermal Energy Storage (MOST) Systems offer a promising avenue for efficient energy storage.
Karoline Schjelde, Oscar B. Obel, Andreas Erbs Hillers-Bendtsen, Kurt V. Mikkelsen   +3 more
doaj   +1 more source

Rapid Access to Photoswitchable RNA Binders: Fluorination Enhances Protein Rescue by Exon Inclusion

Chemistry – A European Journal, EarlyView.
An adaptable approach, many light‐switchable RNA binders. We report a versatile strategy for rapidly synthesizing photoswitchable RNA binders. The ligands can target SMN2 pre‐mRNA, restoring the levels of the corresponding protein by exon‐inclusion rescue.
Lei Zhang, Nemanja Djokovic, Alexander Herr, Anna Wacker, Emily Swanson Hay, Daniel Santana, Amanda E. Hargrove, Harald Schwalbe, Katarina Nikolic, Frank Abendroth, Olalla Vázquez   +10 more
wiley   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Molekulare Solarthermiespeicher—zwei Fallstudien zur Optimierung Molecular solar thermal storage—two case studies on optimization

Chemie Ingenieur Technik, EarlyView.
Molekulare Solarthermiespeicher (MOST) überführen Licht in Wärmeenergie, die zu einem späteren Zeitpunkt genutzt werden kann. Die Optimierung solcher Systeme wird von vielen Parametern bestimmt, wie hier an zwei Beispielmolekülklassen, Azobenzole und Azaborinine, gezeigt.
Sonja M. Biebl, Holger F. Bettinger, Hermann A. Wegner   +2 more
wiley   +1 more source

Directly Sunlight‐Chargeable Core‐Shell Azobenzene Fabric via Coaxial Electrospinning with Tunable Personal Thermal Management

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This work presents a leakage‐free, sunlight‐chargeable core‐shell Azo‐based textile that effectively bridges molecular photothermal storage with wearable functionality, offering a robust platform for on‐demand solar‐powered personal thermal management.
Yating Zhang, Liqi Dong, Hua Pan, Mo Zhou, Fei Zhai, Zhiping Ye, Wei Feng   +6 more
wiley   +1 more source

Anion‐Receptive Triazine‐Centered Azobenzene Trimers

European Journal of Organic Chemistry, EarlyView.
Triazine‐centered azobenzene trimers combine visible‐light switching and anion‐responsive charge‐transfer absorption in a single C3‐symmetric platform, establishing triazine scaffolds as versatile, multistimuli photoswitches for adaptive molecular and supramolecular materials.
Awatef Ayadi, Atiur Rahaman, Quentin Deborde, Valentin Magné, Orein F. Jafter, Dominik Lungerich   +5 more
wiley   +1 more source

Diarylethene‐Containing Photoswitchable Analogues of Tubulysins—Design, Synthesis, Biological, and Structural Evaluation

European Journal of Organic Chemistry, EarlyView.
Diarylethene‐containing cyclic tubulysin analogues were designed, synthesized, and evaluated as light‐responsive cytotoxic agents. One analogue showed reversible photoswitching, photoregulated tubulin polymerization inhibition, and photoform‐dependent cytotoxicity.
Anna Iampolska, Sergii Afonin, Oleg Babii, Mahri Park, Juan Estévez‐Gallego, Michel O. Steinmetz, Andrea E. Prota, Anne S. Ulrich, David R. Spring, Igor V. Komarov   +9 more
wiley   +1 more source

Enhanced CRISPR‐cas systems for genome editing and molecular diagnostics

Interdisciplinary Medicine, EarlyView.
This review systematically summarizes the major optimization strategies for CRISPR‐Cas systems, focusing on the engineering of Cas proteins, guide RNAs, reporter probes, and the incorporation of chemical additives. The aim is to enhance editing precision and diagnostic capability, thereby expanding the CRISPR system's potential for broader biomedical ...
Sheng Li, Han Li, Bojie Chen, Ling Jiang, Keyu Long, Jiaqi Lang, Xingxiang Pu, Erhu Xiong   +7 more
wiley   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source