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Azole-resistant aspergillosis [PDF]
Journal of Infection, 2015 Azole-resistance in Aspergillus fumigatus is emerging and is becoming an increasing problem in the management of aspergillosis. Two types of development of resistance have been described; resistance acquired during azole treatment in an individual patient and through environmental exposure to fungicides. The main molecular mechanism of azole resistance
Warris, A.
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Synthesis of New Azolyl Azoles and Azinyl Azoles.
ChemInform, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
Balkis Al-Saleh +2 more
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The Journal of Infectious Diseases, 1990
The treatment of opportunistic infections in AIDS patients is changing rapidly as new drugs become available and new studies of old drugs are completed. I have tried to use the AIDS commentaries to keep up with these advances. Since fluconazole has just recently been approved by the US Food and Drug Administration, I asked Dr. Robert A.
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The treatment of opportunistic infections in AIDS patients is changing rapidly as new drugs become available and new studies of old drugs are completed. I have tried to use the AIDS commentaries to keep up with these advances. Since fluconazole has just recently been approved by the US Food and Drug Administration, I asked Dr. Robert A.
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Sulfonyl Azoles in the Synthesis of 3-Functionalized Azole Derivatives
The Chemical Record, 2016Sulfonyl indoles, as well as related azolyl derivatives, have been recently introduced in synthesis as stable precursors of reactive indolenine intermediates. This personal account reports on the discovery of sulfonyl azoles and their practical utilization in many synthetic processes for the preparation of functionalized 3-substituted indoles ...
PALMIERI, Alessandro, PETRINI, Marino
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Seminars in Respiratory and Critical Care Medicine, 2008
This is a comprehensive, clinically oriented review of the four commercially available triazoles: fluconazole, itraconazole, voriconazole, and posaconazole. Emphasis is placed in pharmacology, drug interactions, adverse events, antifungal activity, and the evolving perspective of their clinical use.
Dimitrios I, Zonios, John E, Bennett
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This is a comprehensive, clinically oriented review of the four commercially available triazoles: fluconazole, itraconazole, voriconazole, and posaconazole. Emphasis is placed in pharmacology, drug interactions, adverse events, antifungal activity, and the evolving perspective of their clinical use.
Dimitrios I, Zonios, John E, Bennett
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Expert Opinion on Emerging Drugs, 2005
Systemic and superficial fungal infections have progressively emerged over the past few decades as an increasing cause of human disease, especially in the immunocompromised host. Control of fungal disease has proved difficult because few risk factors are potentially preventable; the population at highest risk for fungal disease, the immunocompromised ...
Anne, Chen, Jack D, Sobel
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Systemic and superficial fungal infections have progressively emerged over the past few decades as an increasing cause of human disease, especially in the immunocompromised host. Control of fungal disease has proved difficult because few risk factors are potentially preventable; the population at highest risk for fungal disease, the immunocompromised ...
Anne, Chen, Jack D, Sobel
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2000
Abstract Systemic administration is accompanied by headache and somnolence in 10% of cases. Acute toxic psychosis with confusion, hallucinations, and delusions is rarely described with each agent (1,2). Intrathecal administration is associ ated with arachnoiditis, without ischemic myelopathy (3). The azole antifungal
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Abstract Systemic administration is accompanied by headache and somnolence in 10% of cases. Acute toxic psychosis with confusion, hallucinations, and delusions is rarely described with each agent (1,2). Intrathecal administration is associ ated with arachnoiditis, without ischemic myelopathy (3). The azole antifungal
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Clinical Infectious Diseases, 1992
The discovery of the antifungal activity of azole compounds represented an important therapeutic advance. Miconazole, ketoconazole, and fluconazole are currently commercially available, and itraconazole has undergone extensive clinical evaluation. Because of its limited activity and toxicity, miconazole has been replaced by newer agents.
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The discovery of the antifungal activity of azole compounds represented an important therapeutic advance. Miconazole, ketoconazole, and fluconazole are currently commercially available, and itraconazole has undergone extensive clinical evaluation. Because of its limited activity and toxicity, miconazole has been replaced by newer agents.
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Synthesis of N-(α-Fluorovinyl)azoles by the Reaction of Difluoroalkenes with Azoles
The Journal of Organic Chemistry, 2014A mild and versatile method for the construction of C-N bonds by the reaction of (2,2-difluorovinyl)arenes with various N-H-containing heterocycles in the presence of K3PO4 has been developed. The reaction proceeded efficiently at room temperature (25 °C) affording the (E)-N-α-fluorovinyl derivatives of azoles 3 in good to excellent yields with ...
Yang, Xiong +3 more
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