Results 211 to 220 of about 30,341 (234)
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Molecular aspects of azole antifungal action and resistance
Drug Resistance Updates, 1999During the past three decades azole compounds have been developed as medical and agricultural agents to combat fungal diseases. During the 1980s they were introduced as orally active compounds in medicine and the number of such azole drugs is likely to expand in the near future.
David, Lamb, Diane, Kelly, Steven, Kelly
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Resistance of yeasts to azole-derivative antifungals
Journal of Antimicrobial Chemotherapy, 1993There are relatively few antifungal agents available for the treatment of systemic mycoses. The incidence of these infections, particularly among the immunocompromised, has increased significantly in recent years. Amphotericin B, flucytosine and the azole-derivatives--fluconazole, itraconazole and ketoconazole--are the only drugs of value in the ...
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Resistance to Azole Drugs in Neurospora crassa
Experimental Mycology, 1995Neurospora crassa was susceptible to azole drugs: ketoconazole (MIC 1 microgram/ml), fluconazole (MIC 5 micrograms/ml), and SCH39304 (MIC 5 micrograms/ml). Mutants of N. crassa resistant to ketoconazole were selected and genetically characterized. The seven characterized resistance mutations represented at least four genetic loci. Some mutants, but not
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Antibiotic resistance in the patient with cancer: Escalating challenges and paths forward
Ca-A Cancer Journal for Clinicians, 2021Amila K Nanayakkara, Kevin Outterson
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Azole resistance survey on clinical Aspergillus fumigatus isolates in Spain
Clinical Microbiology and Infection, 2021Pilar Escribano Martos +2 more
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Multi-azole resistance in aspergillus
European Infectious Disease, 2011Azole resistance in Aspergillus has emerged since 2007, especially in northern Europe. Patients with untreatable infection are becoming more frequent. The link between azole fungicides in agriculture is compelling, but not proven. Environmental isolates which are resistant tend to have one marker mutation, whereas isolates arising during therapy have ...
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The rapid emergence of antifungal-resistant human-pathogenic fungi
Nature Reviews Microbiology, 2023Shawn R Lockhart +2 more
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