Results 201 to 210 of about 30,341 (234)

Fungal Drug Resistance: Azoles

2009
Azole antifungal agents are widely used in the clinical arena to treat a variety of fungal infections. The azoles inhibit fungal lanosterol demethylase, a key fungal enzyme in the ergosterol biosynthetic pathway, leading to an altered membrane physiology and, most frequently, a fungistatic effect.
Jose L. Lopez-Ribot, Thomas F. Patterson
openaire   +1 more source

Azole Resistance in Dermatophytes

Journal of the American Podiatric Medical Association, 2016
Azole antifungal agents (eg, fluconazole and itraconazole) have been widely used to treat superficial fungal infections caused by dermatophytes and, unlike the allylamines (such as terbinafine and naftifine), have been associated with resistance development.
openaire   +1 more source

Molecular basis of resistance to azole antifungals

Trends in Molecular Medicine, 2002
The increased incidence of invasive mycoses and the emerging problem of antifungal drug resistance has prompted investigations of the underlying molecular mechanisms, particularly for the azole compounds central to current therapy. The target site for the azoles is the ERG11 gene product, the cytochrome P450 lanosterol 14alpha-demethylase, which is ...
LUPETTI, ANTONELLA, DANESI, ROMANO, CAMPA, MARIO, M. Del Tacca, S. Kelly   +4 more
openaire   +2 more sources

An azole-resistant isolate of Malassezia pachydermatis

Veterinary Microbiology, 2011
Canine Malassezia dermatitis (MD) is frequently treated with systemic ketoconazole (KTZ) and itaconazole (ITZ). However, the antifungal susceptibility of clinical isolates of M. pachydermatis from dogs and cats to the azoles has not been well investigated.
Misako, Nijima, Rui, Kano, Masahiko, Nagata, Atsuhiko, Hasegawa, Hiroshi, Kamata   +4 more
openaire   +2 more sources

Molecular Detection of Resistance to Azole Components

2016
Fungal infections have increased significantly in the last few years, and their outcomes are in part complicated by the emergence of antifungal drug-resistant pathogens. Together with Candida species, the mould Aspergillus fumigatus is one of the most prevalent organisms to cause invasive fungal disease. The molecular detection of (tri)azole resistance
Posteraro, Brunella, Vella, Antonietta, De Carolis, Elena, Sanguinetti, Maurizio   +3 more
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Azole resistant Aspergillus fumigatus: An emerging problem

Médecine et Maladies Infectieuses, 2013
Azole resistance has appeared recently in Aspergillus fumigatus and increased dangerously in the last decade. The main resistance mechanism is a point mutation of CYP51A, the gene encoding 14α-sterol demethylase, the target enzyme of azole antifungal drugs. This mutation can induce resistance to itraconazole alone or multi-azole resistance.
L, Lelièvre, M, Groh, C, Angebault, A-C, Maherault, E, Didier, M-E, Bougnoux   +5 more
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Antifungal drug resistance to azoles and polyenes

The Lancet Infectious Diseases, 2002
There is an increased awareness of the morbidity and mortality associated with fungal infections caused by resistant fungi in various groups of patients. Epidemiological studies have identified risk factors associated with antifungal drug resistance.
Mar, Masiá Canuto, Félix, Gutiérrez Rodero   +1 more
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Azole resistance in Aspergillus fumigatus

Current Opinion in Infectious Diseases, 2013
Reports from the end of the 2000s forced the medical community to take azole resistance in Aspergillus fumigatus into account. Not only patients with chronic aspergillus disease, who develop resistance during long-term azole treatment, but also azole-naive patients are at risk, owing to the presence of resistant strains in the environment.
Vermeulen, E., Lagrou, K., Verweij, P.E.
openaire   +3 more sources

The impact of azole resistance on aspergillosis guidelines

Annals of the New York Academy of Sciences, 2012
Azole resistance in Aspergillus species may be on the rise, with significant potential implications for the management of invasive aspergillosis. The main mechanism of azole resistance in Aspergillus fumigatus is via alterations of the target enzyme CYP51A.
Sarah P, Georgiadou, Dimitrios P, Kontoyiannis   +1 more
openaire   +2 more sources

Azole resistance in Aspergillus fumigatus- comprehensive review

Archives of Microbiology
Aspergillus fumigatus is a ubiquitous filamentous fungus commonly found in the environment. It is also an opportunistic human pathogen known to cause a range of respiratory infections, such as invasive aspergillosis, particularly in immunocompromised individuals.
Mthokozisi, Dladla, Marieka, Gyzenhout, Gert, Marias, Soumya, Ghosh   +3 more
openaire   +2 more sources