Results 181 to 190 of about 16,315 (211)
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Resistance to Azole Drugs in Neurospora crassa
Experimental Mycology, 1995Neurospora crassa was susceptible to azole drugs: ketoconazole (MIC 1 microgram/ml), fluconazole (MIC 5 micrograms/ml), and SCH39304 (MIC 5 micrograms/ml). Mutants of N. crassa resistant to ketoconazole were selected and genetically characterized. The seven characterized resistance mutations represented at least four genetic loci. Some mutants, but not
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Azole-Resistant Invasive Aspergillosis: Relationship to Agriculture
Current Fungal Infection Reports, 2012Azole resistance in Aspergillus fumigatus has been increasingly reported particularly over the last decade. Two routes of acquisition are described: selection of resistance during long term azole therapy in the clinical setting, and primary acquisition of resistant isolates from the environment due to the considerable use of azole fungicides in ...
Stensvold, Christen Rune +2 more
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Molecular aspects of azole antifungal action and resistance
Drug Resistance Updates, 1999During the past three decades azole compounds have been developed as medical and agricultural agents to combat fungal diseases. During the 1980s they were introduced as orally active compounds in medicine and the number of such azole drugs is likely to expand in the near future.
David, Lamb, Diane, Kelly, Steven, Kelly
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Fungal Drug Resistance: Azoles
2009Azole antifungal agents are widely used in the clinical arena to treat a variety of fungal infections. The azoles inhibit fungal lanosterol demethylase, a key fungal enzyme in the ergosterol biosynthetic pathway, leading to an altered membrane physiology and, most frequently, a fungistatic effect.
Jose L. Lopez-Ribot, Thomas F. Patterson
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Azole resistance in Aspergillus fumigatus
Current Opinion in Infectious Diseases, 2013Reports from the end of the 2000s forced the medical community to take azole resistance in Aspergillus fumigatus into account. Not only patients with chronic aspergillus disease, who develop resistance during long-term azole treatment, but also azole-naive patients are at risk, owing to the presence of resistant strains in the environment.
Vermeulen, E., Lagrou, K., Verweij, P.E.
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Azole Resistance in Dermatophytes: Prevalence and Mechanism of Action
Journal of the American Podiatric Medical Association, 2015Azole antifungal agents (eg, fluconazole and itraconazole) have been widely used to treat superficial fungal infections caused by dermatophytes and, unlike the allylamines (such as terbinafine and naftifine), have been associated with resistance development.
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Azole resistance survey on clinical Aspergillus fumigatus isolates in Spain
Clinical Microbiology and Infection, 2021Patricia Carmen Muñoz García +2 more
exaly
Resistance to azole fungicides in the field
Biochemical Society Transactions, 1993openaire +2 more sources