Results 171 to 180 of about 16,315 (211)

Molecular basis of resistance to azole antifungals

Trends in Molecular Medicine, 2002
The increased incidence of invasive mycoses and the emerging problem of antifungal drug resistance has prompted investigations of the underlying molecular mechanisms, particularly for the azole compounds central to current therapy. The target site for the azoles is the ERG11 gene product, the cytochrome P450 lanosterol 14alpha-demethylase, which is ...
LUPETTI, ANTONELLA, DANESI, ROMANO, CAMPA, MARIO, M. Del Tacca, S. Kelly   +4 more
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Azole-resistant aspergillosis

Journal of Infection, 2015
Azole-resistance in Aspergillus fumigatus is emerging and is becoming an increasing problem in the management of aspergillosis. Two types of development of resistance have been described; resistance acquired during azole treatment in an individual patient and through environmental exposure to fungicides. The main molecular mechanism of azole resistance
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Molecular Detection of Resistance to Azole Components

2016
Fungal infections have increased significantly in the last few years, and their outcomes are in part complicated by the emergence of antifungal drug-resistant pathogens. Together with Candida species, the mould Aspergillus fumigatus is one of the most prevalent organisms to cause invasive fungal disease. The molecular detection of (tri)azole resistance
Posteraro, Brunella, Vella, Antonietta, De Carolis, Elena, Sanguinetti, Maurizio   +3 more
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The impact of azole resistance on aspergillosis guidelines

Annals of the New York Academy of Sciences, 2012
Azole resistance in Aspergillus species may be on the rise, with significant potential implications for the management of invasive aspergillosis. The main mechanism of azole resistance in Aspergillus fumigatus is via alterations of the target enzyme CYP51A.
Sarah P, Georgiadou, Dimitrios P, Kontoyiannis   +1 more
openaire   +2 more sources

Multi-azole resistance in Aspergillus fumigatus

International Journal of Antimicrobial Agents, 2006
Azole resistance in Aspergillus spp. is unusual. We report a patient who received long-term treatment with itraconazole and voriconazole for bilateral chronic cavitary aspergillosis with aspergillomas whose isolates of Aspergillus fumigatus developed simultaneous resistance to itraconazole and voriconazole.
Howard, Susan J., Webster, Ian, Moore, Caroline B., Gardiner, Rebecca E., Park, Steven, Perlin, David S., Denning, David W.; id_orcid 0000-0001-5626-2251   +6 more
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Azole resistance inCandida albicans

Medical Mycology, 1986
An isolate of Candida albicans from a patient with chronic mucocutaneous candidosis who relapsed during ketoconazole treatment was compared with a number of other azole-sensitive and azole-resistant isolates by tests in vitro and in three animal models of vaginal or disseminated infection.
K J, Smith, D W, Warnock, C T, Kennedy, E M, Johnson, V, Hopwood, J, Van Cutsem, H, Vanden Bossche   +6 more
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Azole Resistance in Dermatophytes

Journal of the American Podiatric Medical Association, 2016
Azole antifungal agents (eg, fluconazole and itraconazole) have been widely used to treat superficial fungal infections caused by dermatophytes and, unlike the allylamines (such as terbinafine and naftifine), have been associated with resistance development.
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Resistance of yeasts to azole-derivative antifungals

Journal of Antimicrobial Chemotherapy, 1993
There are relatively few antifungal agents available for the treatment of systemic mycoses. The incidence of these infections, particularly among the immunocompromised, has increased significantly in recent years. Amphotericin B, flucytosine and the azole-derivatives--fluconazole, itraconazole and ketoconazole--are the only drugs of value in the ...
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Azole Antifungal Resistance Today: Focus on Aspergillus

Current Infectious Disease Reports, 2011
Oral triazole therapy is well established for the treatment of invasive aspergillosis (IPA), allergic aspergillosis (ABPA), and chronic pulmonary aspergillosis (CPA), and is often long-term. Resistance to triazole azole antifungal drugs in Aspergillus fumigatus is now a major clinical problem in a number of European locations, in China, Canada and the ...
Bowyer, Paul, Moore, Caroline B., Rautemaa-Richardson, Riina; id_orcid 0000-0002-1071-6040, Denning, David W.; id_orcid 0000-0001-5626-2251, Richardson, Malcolm   +4 more
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Azole resistance mechanisms in pathogenic M. furfur.

Antimicrobial agents and chemotherapy, 2021
Malassezia are emerging fungal pathogens causing opportunistic skin and severe systemic infection. Nosocomial outbreaks are associated with azole resistance and understanding of the underlying mechanisms are limited to knowledge from other fungal species. Herein, we identified distinct antifungal susceptibility patterns in 26 Malassezia furfur isolates
Leong, Cheryl, Kit, Joel Chan Wai, Lee, Shi Mun, Lam, Yuen In, Goh, Joleen P Z, Ianiri, Giuseppe, Dawson, Thomas L   +6 more
openaire   +2 more sources