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Azole Resistance in Candida glabrata
Current Infectious Disease Reports, 2016Candida infections have increased due to the growth and expansion of susceptible patient populations. The azole fluconazole is the most widely prescribed antifungal, but rising rates of clinical resistance among Candida glabrata isolates have greatly limited its utility.
Sarah Whaley +2 more
exaly +3 more sources
Emergence of Azole Resistance in Aspergillus
Seminars in Respiratory and Critical Care Medicine, 2015Resistance to the azole antifungals itraconazole, voriconazole, and posaconazole in Aspergillus species is a growing concern. This is especially alarming for A. fumigatus, where acquired resistance has been documented in patients with invasive disease caused by this species that were exposed to these agents, as well as in azole-naive individuals.
Nathan Wiederhold
exaly +3 more sources
Multi-azole resistance in Aspergillus fumigatus
International Journal of Antimicrobial Agents, 2006Azole resistance in Aspergillus spp. is unusual. We report a patient who received long-term treatment with itraconazole and voriconazole for bilateral chronic cavitary aspergillosis with aspergillomas whose isolates of Aspergillus fumigatus developed simultaneous resistance to itraconazole and voriconazole.
David Denning +2 more
exaly +3 more sources
Assessment of Azole Resistance in Healthcare Facilities
2021Azole resistance among fungal species has been increasing worldwide in recent years, representing a public health concern in the management of fungal infections. The complex environment of healthcare facilities, where microbial agents, including fungal contamination, are present must be controlled in order to protect susceptible patients. In this study,
Caetano, Liliana Aranha +2 more
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Molecular basis of resistance to azole antifungals
Trends in Molecular Medicine, 2002The increased incidence of invasive mycoses and the emerging problem of antifungal drug resistance has prompted investigations of the underlying molecular mechanisms, particularly for the azole compounds central to current therapy. The target site for the azoles is the ERG11 gene product, the cytochrome P450 lanosterol 14alpha-demethylase, which is ...
LUPETTI, ANTONELLA +4 more
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An azole-resistant isolate of Malassezia pachydermatis
Veterinary Microbiology, 2011Canine Malassezia dermatitis (MD) is frequently treated with systemic ketoconazole (KTZ) and itaconazole (ITZ). However, the antifungal susceptibility of clinical isolates of M. pachydermatis from dogs and cats to the azoles has not been well investigated.
Misako, Nijima +4 more
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Azole resistance inCandida albicans
Medical Mycology, 1984Two isolates of Candida albicans from chronic mucocutaneous candidosis patients who initially responded to ketoconazole treatment but who later relapsed, have shown an abnormal response to ketoconazole in four out of five systems in vitro and in three animal models of vaginal or systemic infection. They have also shown abnormal resistance to inhibition
J F, Ryley +2 more
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Journal of Infection, 2015
Azole-resistance in Aspergillus fumigatus is emerging and is becoming an increasing problem in the management of aspergillosis. Two types of development of resistance have been described; resistance acquired during azole treatment in an individual patient and through environmental exposure to fungicides. The main molecular mechanism of azole resistance
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Azole-resistance in Aspergillus fumigatus is emerging and is becoming an increasing problem in the management of aspergillosis. Two types of development of resistance have been described; resistance acquired during azole treatment in an individual patient and through environmental exposure to fungicides. The main molecular mechanism of azole resistance
openaire +2 more sources
The impact of azole resistance on aspergillosis guidelines
Annals of the New York Academy of Sciences, 2012Azole resistance in Aspergillus species may be on the rise, with significant potential implications for the management of invasive aspergillosis. The main mechanism of azole resistance in Aspergillus fumigatus is via alterations of the target enzyme CYP51A.
Sarah P, Georgiadou +1 more
openaire +2 more sources
Molecular Detection of Resistance to Azole Components
2016Fungal infections have increased significantly in the last few years, and their outcomes are in part complicated by the emergence of antifungal drug-resistant pathogens. Together with Candida species, the mould Aspergillus fumigatus is one of the most prevalent organisms to cause invasive fungal disease. The molecular detection of (tri)azole resistance
Posteraro, Brunella +3 more
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