Results 221 to 230 of about 22,992 (261)
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The role of azoles in the management of azole-resistant aspergillosis: From the bench to the bedside
Drug Resistance Updates, 2014Azole resistance is an emerging problem in Aspergillus fumigatus and is associated with a high probability of treatment failure. An azole resistance mechanism typically decreases the activity of multiple azole compounds, depending on the mutation. As alternative treatment options are limited and in some isolates the minimum inhibitory concentration ...
Seyedmousavi, S. +4 more
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Journal of Infection, 2015
Azole-resistance in Aspergillus fumigatus is emerging and is becoming an increasing problem in the management of aspergillosis. Two types of development of resistance have been described; resistance acquired during azole treatment in an individual patient and through environmental exposure to fungicides. The main molecular mechanism of azole resistance
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Azole-resistance in Aspergillus fumigatus is emerging and is becoming an increasing problem in the management of aspergillosis. Two types of development of resistance have been described; resistance acquired during azole treatment in an individual patient and through environmental exposure to fungicides. The main molecular mechanism of azole resistance
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Synthesis of N-(α-Fluorovinyl)azoles by the Reaction of Difluoroalkenes with Azoles
The Journal of Organic Chemistry, 2014AbstractA slight excess (1.2 equiv.) of difluoroalkene reacts with various N‐heterocycles to afford monosubstituted (E)‐configurated products.
Xuxue Zhang +3 more
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N-(Difluoroamino)azoles – a new class of N-substituted azoles
Mendeleev Communications, 1996AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
V. M. Vinogradov +3 more
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Clinical Infectious Diseases, 1992
The discovery of the antifungal activity of azole compounds represented an important therapeutic advance. Miconazole, ketoconazole, and fluconazole are currently commercially available, and itraconazole has undergone extensive clinical evaluation. Because of its limited activity and toxicity, miconazole has been replaced by newer agents.
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The discovery of the antifungal activity of azole compounds represented an important therapeutic advance. Miconazole, ketoconazole, and fluconazole are currently commercially available, and itraconazole has undergone extensive clinical evaluation. Because of its limited activity and toxicity, miconazole has been replaced by newer agents.
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Reaction of tetracyanoquinodimethane with azoles [PDF]
Chemistry of Heterocyclic Compounds, 1976 The reaction of tetracyanoquinodimethane (TCQD) with azoles was studied. It was found that products of 1,6 addition to the quinoid system of TCQD are formed with pyrrole, indole, and their methyl derivatives. The addition products split out HCN under the influence of UV light to give deeply colored products of replacement of one nitrile group in TCQD ...
E. V. Getmanova +3 more
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Trifluoromethanesulfonamide derivatives of azoles
Journal of Fluorine Chemistry, 2011Abstract Trifluoromethanesulfonamide-substituted azoles were synthesized by the reaction of 5-aminotetrazole, 3-amino-1,2,4-triazole and 3,5-diamine-1,2,4-triazole with trifluoromethanesulfonyl fluoride to prepare only monosubstituted compounds. All the compounds were fully characterized using ( 1 H, 19 F, 13 C) NMR spectroscopy, mass spectrometry (
Jean'ne M. Shreeve, Sonali Garg
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Médecine et Maladies Infectieuses, 1984
Resume Les premiers azoles antifongiques possedent un spectre d'activite restreint. L'etonam (R 10100) etait actif contre les dermatophytes a la fois in vitro et in vivo par application topique. Le spectre antimycosique dans le traitement topique s'est elargi avec le miconazole et le clotrimazole.
P. A. J. Janssen, J. Van Cutsem
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Resume Les premiers azoles antifongiques possedent un spectre d'activite restreint. L'etonam (R 10100) etait actif contre les dermatophytes a la fois in vitro et in vivo par application topique. Le spectre antimycosique dans le traitement topique s'est elargi avec le miconazole et le clotrimazole.
P. A. J. Janssen, J. Van Cutsem
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Energetic Azolium Azolate Salts
Inorganic Chemistry, 2005Energetic salts comprising substituted imidazolium and 1,2,4-triazolium cations and 4,5-dinitro-imidazolate and 5-nitrotetrazolate anions were synthesized and characterized. On the basis of experimentally obtained heats of combustion, the calculated heats of formation range from deltaHf(o) degrees = 80 (3) to 1071 kJ/mol (13).
Jean'ne M. Shreeve +3 more
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Synthesis of Polynuclear Nonfused Azoles
Russian Journal of Organic Chemistry, 2003AbstractFor Abstract see ChemInform Abstract in Full Text.
A. V. Rokhin +4 more
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