Results 61 to 70 of about 14,586 (194)

Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells

Nature Communications, 2020
Non-obstructive azoospermia affects 1% of men. Here, authors perform single-cell transcriptomic analysis of human testicular cells from healthy donors and non-obstructive azoospermia patients and find that inhibition of Wnt signaling promotes the ...
LiangYu Zhao, ChenCheng Yao, XiaoYu Xing, Tao Jing, Peng Li, ZiJue Zhu, Chao Yang, Jing Zhai, RuHui Tian, HuiXing Chen, JiaQiang Luo, NaChuan Liu, ZhiWen Deng, XiaoHan Lin, Na Li, Jing Fang, Jie Sun, ChenChen Wang, Zhi Zhou, Zheng Li   +19 more
doaj   +1 more source

Neoplastic Risk in Patients With Klinefelter Syndrome

Andrology, EarlyView.
ABSTRACT Background Besides gonadal involvement (hypogonadism, male factor infertility, and testicular hypotrophy), patients with Klinefelter syndrome (KS) may suffer from several extra‐gonadic complications, including neoplastic events. Objective The aim of this review is to summarize all major clinical evidence dealing with the association between KS
Andrea Graziani, Giuseppe Grande, Riccardo Selice, Antonella Di Mambro, Alberto Ferlin   +4 more
wiley   +1 more source

Machine Learning‐Based Prediction of Sperm Retrieval Outcomes in Patients With Klinefelter Syndrome: A Multicenter Study With External Validation

Andrology, EarlyView.
ABSTRACT Background The Klinefelter syndrome is a common genetic cause of male infertility, and testicular sperm extraction (TESE) enables sperm retrieval in a subset of affected patients. However, predicting TESE success remains challenging due to the heterogeneous clinical and endocrinological presentation of the Klinefelter syndrome.
Murat Gül, Ali Şahin, Cevahir Özer, Mesut Altan, Tansu Güdelci, Kadir Can Sahin, Mehmet Hamza Gültekin, Muhammed Arif İbis, Mesut Berkan Duran, Burak Sivaslıoğlu, Eray Hasırcı, Mert Kılıç, Ali Can Albaz, Gökhan Çeker, Gianmaria Salvio   +14 more
wiley   +1 more source

Testicular Biopsies in Adolescent and Adult Andrological Patients: The EAA Clinical Guidelines

Andrology, EarlyView.
ABSTRACT Background Histological evaluation of testicular tissue is central to the assessment of infertile men, particularly those at an increased risk of testicular germ cell tumors (TGCT). Traditionally, testicular biopsies have been used primarily for diagnostic purposes, such as the detection of germ cell neoplasia in situ (GCNIS). With advances in
Lise Aksglaede, George Kanakis, Ewa Rajpert‐De Meyts, Davor Jezek, Ferran Algaba, Gert Dohle, Jolanta Slowikowska‐Hilczer, Sabine Kliesch, Hermann M. Behre, Csilla Krausz, Dimitrios G. Goulis, Niels Jørgensen   +11 more
wiley   +1 more source

Azoospermia Due to Functional and Partial Ejaculatory Duct Obstruction: A Rare Case Report and Literature Review

American Journal of Men's Health
Ejaculatory duct obstruction (EDO) is a rare but treatable cause of male infertility. This case report describes a 28-year-old male with obstructive azoospermia. The patient came to our hospital after a fertility check-up revealed azoospermia.
Lei Zheng, Lihong Wang, Hui Jiang, Tao Jiang   +3 more
doaj   +1 more source

Sperm Mitochondrial DNA Copy Number and Nuclear DNA Methylation Across Clinical and Non‐Clinical Preconception Cohorts

Andrology, EarlyView.
ABSTRACT Background Sperm mitochondrial DNA copy number is an emerging marker of male fertility, with elevated mtDNAcn associated with poor semen quality across various populations. Sperm DNA methylation has also been previously demonstrated to be negatively correlated with semen parameters in IVF cohorts.
Savni Sawant, Karolina Nowak, Amanda L. Paskavitz, Emily Houle, Ricardo P. Bertolla, Lidia Minguez‐Alarcon, Russ Hauser, J. Richard Pilsner   +7 more
wiley   +1 more source

Clinician’s guide to the management of azoospermia induced by exogenous testosterone or anabolic–androgenic steroids

Asian Journal of Andrology
Azoospermia, defined as the absence of sperm in the ejaculate, is a well-documented consequence of exogenous testosterone (ET) and anabolic–androgenic steroid (AAS) use.
Manaf Al Hashimi, Germar-Michael Pinggera, Rupin Shah, Ashok Agarwal   +3 more
doaj   +1 more source

Obesity Is an Independent Risk Factor for Oligozoospermia, With Co‐Existing Hyperglycemia Exacerbating Risks of Asthenozoospermia and Elevated Sperm DNA Fragmentation

Andrology, EarlyView.
ABSTRACT Background Metabolic health plays a critical role in maintaining male fertility and may influence offspring health. Therefore, it is necessary to incorporate metabolic indicators into the clinical assessment of male fertility. However, the relationships between different metabolic abnormalities and semen quality remain incompletely understood.
Rubing Hu, Haijiao Zou, Qiaodan Li, Weihong Fan, Jian Xu   +4 more
wiley   +1 more source

The combined effects of swimming exercise and stem cell transplantation on the expression of CD9 and CD63 tetraspanin genes in a rat model of azoospermia

مجله علوم پزشکی فیض (پیوسته)
Background and Aim: Azoospermia, defined as the absence of sperm in semen, is a common cause of male infertility. This study aimed to determine the combined effects of swimming exercise and stem cell transplantation on the expression of CD9 and CD63 ...
Maziyar Shojaee, lida moradi, Parvin Farzanei, Bahram Abedi   +3 more
doaj  

A Study on Causes of Azoospermia in Urology Clinic of Yasuj University of Medical Sciences

Armaghane Danesh Bimonthly Journal, 2006
: Introduction & Objective: Azoospermia means no sperm in semen. It may be due to hormonal imbalance, any disorder in production of sperm, or might be due to obstruction in sperm pathway from testis till ejaculatory ducts.
SMR Rabani, A Moosavizadeh
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