Results 81 to 90 of about 14,478 (190)

Semen Cryopreservation in Testicular Cancer: Before or After Orchidectomy?

Andrology, Volume 14, Issue 5, Page 1272-1281, July 2026.
ABSTRACT Background Fertility preservation in patients with testicular cancer remains a clinical priority, yet the optimal timing for sperm cryopreservation—before or after orchidectomy—remains a matter of debate. Objectives The aim of this study was to determine the optimal timing for semen cryopreservation and the best‐quality sample for ART.
Alessandra Buonacquisto, Carlotta Pozza, Gaia Cicolani, Anna Chiara Conflitti, Luisa Caponecchia, Serena Bianchini, Enrico Delli Paoli, Marta Tenuta, Daniele Gianfrilli, Andrea M. Isidori, Francesco Lombardo, Francesco Pallotti, Donatella Paoli   +12 more
wiley   +1 more source

Intracytoplasmic sperm injection with fresh versus cryopreserved testicular sperm in azoospermic patients

Middle East Fertility Society Journal, 2019
Background The purpose of this study is to compare the outcome of intracytoplasmic sperm injection (ICSI) using fresh sperm versus frozen-thawed sperm in both obstructed and non-obstructed azoospermias.
Kani M. Falah
doaj   +1 more source

Trends in Semen Quality: A Contrasting Perspective From a Single‐Centre Review in Ireland

Andrology, Volume 14, Issue 5, Page 1164-1171, July 2026.
ABSTRACT Introduction Male factor contributes up to half of infertility cases and reports of a global decline in semen quality raise concern for the future of male reproductive health. However, fertility trends can vary by region and population. Interpreting local patterns is crucial for understanding the true trajectory of male fertility.
Ciara Nolan, Hayley Jackson, Aisling Looney, Jennifer Cullinane, Louise E. Glover, David Crosby, Cathy Allen   +6 more
wiley   +1 more source

Clinical Challenges in Transition to Adult Care for Young People With Endocrinopathies

Clinical Endocrinology, Volume 105, Issue 1, Page 14-21, July 2026.
ABSTRACT The complexity of transition of pediatric patients to adult care is well recognized, with a multidisciplinary approach widely agreed to be essential. Despite extensive existing literature in this area, practical guidance as to the management of specific medical aspects and how to address these with patients and families is lacking, with little
Margaret Zacharin, Quynh‐Nhu Nguyen
wiley   +1 more source

Diagnostic yield of OCT3/4 reflex testing in testicular biopsy

Histopathology, Volume 89, Issue 1, Page 136-143, July 2026.
GCNIS detection frequency was 48/3353 (1.4%) testicular biopsies from 42/1870 (2.2%) men who underwent testicular biopsy with or without testicular sperm extraction (TESE). OCT3/4 was particularly helpful for detecting interstitial seminoma, GCNIS coexisting with mature spermatogenesis, and focal GCNIS.
Roselyne Choiniere, Willem PA Boellaard, Geert JLH van Leenders   +2 more
wiley   +1 more source

Varicocelectomy Restores Spermatogenesis in Fontan‐Associated Varicocele: A Two‐Case Series

IJU Case Reports, Volume 9, Issue 4, July 2026.
ABSTRACT Introduction Fontan circulation may cause chronic venous hypertension and predispose patients to varicocele and infertility, but the clinical significance of surgical treatment remains unclear. Case Presentation We describe two patients with Fontan circulation who developed Fontan‐associated varicocele (FAVC).
Yusuke Tominaga, Tomoko Kobayashi, Yuko Matsumoto, Takatoshi Moriwake, Nariaki Ozaki, Takuya Sadahira, Satoshi Katayama, Shingo Nishimura, Kensuke Bekku, Motoo Araki   +9 more
wiley   +1 more source

DiGeorge Syndrome Associated with Azoospermia: First case in the literature

Urology Research and Practice, 2019
DiGeorge syndrome (DGS) is one of the most frequently seen chromosomal abnormalities. The major genetic cause of DGS is a microdeletion on chromosome 22q11.2. Majority of the cases are diagnosed during their childhood.
Ayşegül Özcan, Yavuz Şahin
doaj   +1 more source

Clinical Features and PLCZ1 Gene Variants in Two Cases of Male Infertility: A Case Series and Literature Review

Molecular Genetics &Genomic Medicine, Volume 14, Issue 6, June 2026.
Our study expands the variant spectrum of PLCZ1, enriches the clinical characteristics of PLCZ1, and provides a solid base for the genetic counseling, diagnosis, and treatment of this condition. ABSTRACT Background Variations in the PLCZ1 gene can lead to male infertility (MIM #617214), an autosomal recessive disorder characterized by failure or ...
Jinwei Yang, Bo Yan, Zhizhuo Wei, Zijing Niu, Tongguang Wang, Yan Wei, Fangzhu Wang, Wei Jiang, Lin Zhang, Yue Da, Huanjing Wang, Yali Ni, Zhiqiang Wang   +12 more
wiley   +1 more source

SOX30 Governs Synaptonemal Complex Assembly and Homologous Recombination in Male Meiosis

Cell Proliferation, Volume 59, Issue 6, June 2026.
The transcription factor SOX30 directly binds promoter regions of SYCE1 and SYCE2 to mediate their transcriptional activation, thereby enabling proper assembly of central elements within the synaptonemal complex. Structural destabilisation of the synaptonemal complex in Sox30 KK spermatocytes triggers synaptic discontinuity, impairs homologous ...
Kangle Liu, Wenfeng Zhang, Xiao Jiang, Jianping Chen, Lei Zhu, Zhonghao Zhang, Jing Gu, Lulu Guo, Lin Ao, Qing Chen, Lei Sun, Yuhan Hu, Xin Wang, Yaxin Liu, Jia Cao, Fei Han, Jinyi Liu   +16 more
wiley   +1 more source

GGAs: Regulation of Multiple Sorting Pathways and Potential Association With Human Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Golgi‐localized gamma‐ear‐containing Arf‐binding proteins (GGAs) are a family of monomeric clathrin adaptors that function in intracellular vesicle trafficking. The three GGA family members—GGA1, GGA2 and GGA3—were first identified as sorting adaptors almost simultaneously by independent research groups in 2000. It is now well established that
Qinqin Wang, Juan Mei, Shuyue Li, Guoan Zhang, Jian Qiu, Xuezhi Li   +5 more
wiley   +1 more source