Results 111 to 120 of about 21,150 (298)
Multitargeted Low-Dose GLAD Combination Chemoprevention: A Novel and Promising Approach to Combat Colon Carcinogenesis [PDF]
, 1967 Preclinical studies have shown that gefitinib, licofelone, atorvastatin, and α-difluoromethylornithine (GLAD) are promising colon cancer chemopreventive agents.
Altaf Mohammed +54 more
core +2 more sources
Preventive Effects of Resveratrol against Azoxymethane Induced Damage in Rat Liver
Asian Pacific Journal of Cancer Prevention, 2013 In recent years, due to modern lifestyles and exposure to chemical carcinogens, cancer cases are steadily increasing. From this standpoint, azoxymethane (AOM), a chemical carcinogen which causes de novo liver damage, and resveratrol, which is an antioxidant found in foods and protects against oxidative stress damage, are of interest.
Gürocak S. +5 more
openaire +5 more sources
STK25 Loss Augments Anti‐PD‐1 Therapy Efficacy by Regulating PD‐L1 Stability in Colorectal Cancer
Advanced Science, Volume 12, Issue 39, October 20, 2025.This study demonstrates that STK25 depletion facilitates CRC immune escape through the inhibition of PD‐L1 Ser283 phosphorylation‐mediated ubiquitination, and promotes tumor growth. Furthermore, these findings identify STK25 as a potential therapeutic target to trigger antitumor immunity and promote immunotherapy efficacy. Abstract Tumor immune evasion
Xiaowen Qiao +20 more
wiley +1 more source
BMC Research Notes, 2018 Objectives (3R)-Falcarinol (FaOH) and (3R,8S)-falcarindiol (FaDOH) have previously been shown to reduce the number of neoplastic lesions and the growth rate of polyps in the colon of azoxymethane (AOM) treated rats.
Morten Kobaek-Larsen +5 more
doaj +1 more source
PLoS ONE, 2015 Annona muricata has been used in folk medicine for the treatment of cancer and tumors. This study evaluated the chemopreventive properties of an ethyl acetate extract of A. muricata leaves (EEAML) on azoxymethane-induced colonic aberrant crypt foci (ACF)
Soheil Zorofchian Moghadamtousi +6 more
semanticscholar +1 more source
Phytotherapy Research, Volume 39, Issue 10, Page 4950-4971, October 2025.Catalpol's potential in inhibiting cancer development and progression through various pathways. ABSTRACT Catalpol, a natural iridoid glycoside known for its anti‐proliferative effects, has been proposed as an anticancer compound. Catalpol targets critical processes involved in cancer cell progression, like malignant proliferation, apoptosis, and ...
Lucas Fornari Laurindo +13 more
wiley +1 more source
Nutrients, 2015 Human and experimental colon carcinogenesis are enhanced by a pro-inflammatory microenvironment. Pharmacologically driven chemopreventive agents and dietary variables are hypothesized to have future roles in the prevention of colon cancer by targeting ...
Ni Shi +8 more
semanticscholar +1 more source
Journal of Neuroinflammation, 2019 Background Acute liver failure resulting from drug-induced liver injury can lead to the development of neurological complications called hepatic encephalopathy (HE). Hepatic transforming growth factor beta 1 (TGFβ1) is upregulated due to liver failure in
Matthew McMillin +8 more
doaj +1 more source
Energy balance and cancers [PDF]
, 1999 Energy balance results from the exact equilibrium between caloric intake and caloric expenditure. A caloric intake larger than caloric expenditure results in overweight, even obesity, but other determinants, like hormonal dysfunction and/or genetic ...
Corpet, Denis E., Gerber, Mariette
core +1 more source
Preventive effects of Resveratrol against azoxymethane-induced testis injury in rats
Andrologia, 2016 To evaluate the protective effects of Resveratrol (RES) on azoxymethane (AOM)-induced testicular damage using histopathology and biochemical analyses, 28 male rats were randomly divided into four groups. Groups were control, RES, AOM and ARES. At the end of the 7 weeks, following routine tissue processing procedure, testis sections were stained with ...
KURUŞ, MELTEM +3 more
openaire +4 more sources