Results 131 to 140 of about 8,111 (184)

Effect of tea on the formation of DNA adducts by azoxymethane

Xenobiotica, 1998
1. The effect of black tea on the conversion of azoxymethane (AOM) to DNA reactive metabolites was studied in four groups of the male F344 rat. Each received 1.25% solutions of tea for 2 or 6 weeks, and simultaneous controls drank water. All rats were injected s.c. twice with 15 mg/kg AOM after the first or fifth week respectively, on tea or water, and
W, Chen, O S, Sohn, E S, Fiala, J H, Weisburger   +3 more
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Inhibition of carcinogenicities of 1,2-dimethylhydrazine and azoxymethane by pyrazole

Cancer Letters, 1982
Inhibitory effects of pyrazole on the carcinogenicities of 2 large-bowel carcinogens, 1,2-dimethylhydrazine (DMH) and azoxymethane (AOM), were examined, because our previous study revealed that pyrazole completely inhibited the induction of mutations by these carcinogens in the host-mediated mutation assay.
M, Moriya, T, Harada, Y, Shirasu
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Inhibition of azoxymethane-induced intestinal cancer by disulfiram

Cancer Letters, 1978
Sprague--Dawley rats, both intact and colostomized animals, were given 24 weekly injections of azoxymethane. Rats were fed either Rat Purina Chow or the same diet plus 0.25% disulfiram. In the intact animals, disulfiram reduced tumors from an average of 6.3 to 0.95. The number of rats developing tumors was reduced from 100% to 60%.
N D, Nigro, R L, Campbell
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Hypergastrinemia in rats with azoxymethane‐induced colon cancers

International Journal of Cancer, 1995
AbstractGastrin has been suggested to be involved in the promotion and progression of colon cancer. Mice colon cancers and colon‐carcinoma cell lines are stimulated to grow by gastrin, and gastrin receptors have been found in the majority of human colon‐tumor specimens.
L, D'Agostino, S, Pignata, G, Tritto, G, D'Adamo, A, Contegiacomo, B, Daniele, R, Calderopoli, C, Pizzi, G, Squame, G, Mazzacca   +9 more
openaire   +2 more sources

Effect of docosahexaenoic acid on azoxymethane-induced colon carcinogenesis in rats

Cancer Letters, 1994
The effect of intragastric gavage administration of docosahexaenoic acid (DHA) on azoxymethane (AOM)-induced colon carcinogenesis in rats was studied. Male F344 rats were treated s.c. with 15 mg/kg of AOM once a week for 2 weeks and were given either 0.7 ml of DHA or water intragastrically twice a week starting the day before the first carcinogen ...
Mami Takahashi, Toshio Kato, Kazunaga Yazawa   +2 more
exaly   +3 more sources

Inhibition of Azoxymethane-Induced Colon Cancer by Orange Juice

Nutrition and Cancer, 2000
Previous research has shown that hesperidin, a flavanone glycoside in orange juice, inhibits colon carcinogenesis and that feeding double-strength orange juice delays the onset of chemically induced mammary cancer in rats. This study determined whether feeding single-strength, pasteurized orange juice would inhibit azoxymethane (AOM)-induced colon ...
Y, Miyagi, A S, Om, K M, Chee, M R, Bennink   +3 more
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Effect of propylthiouracil on intestinal tumor formation by azoxymethane in rats

Experientia, 1977
Treatment with propylthiouracil (PTU) resulted in a significant decrease in azoxymethane-induced intestinal tumors, total concentration of fecal bile acids as well as the fecal neutral steroids, cholesterol and coprostanol. Thus, a hypothyroid state induced by PTU treatment may affect intestinal carcinogenesis in this animal model by lowering the ...
D V, Singh, R L, Campbell, Y N, Lin, N D, Nigro   +3 more
openaire   +2 more sources

AZOXYCOMPOUNDS: I. THE PHOTOLYSIS OF AZOXYMETHANE

Canadian Journal of Chemistry, 1964
A study of the photolysis of azoxymethane has been made. The reaction products include nitrogen, nitrous oxide, methane, and ethane. The ratio N2:N2O is independent of temperature and two primary photolytic processes are postulated to account for this fact.
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Effect of black tea on azoxymethane-induced colon cancer

Carcinogenesis, 1998
Two sets of experiments on the role of tea in azoxymethane (AOM) induced colon cancer were performed. The first test involved male F344 rats given 1.25% solutions of black tea beginning at 5 weeks of age and ending at 51 days of age. At 6 and 7 weeks of age, they received 15 mg/kg AOM and were held for 50 weeks. Another group received the AOM dosage at
J H, Weisburger, A, Rivenson, J, Reinhardt, C, Aliaga, J, Braley, B, Pittman, E, Zang   +6 more
openaire   +2 more sources

Chemoprevention of Azoxymethane-induced Colon Carcinogenesis by Delta-Tocotrienol

Cancer Prevention Research, 2019
Abstract This study evaluated the preclinical activity of δ-tocotrienol (DT3), a bioactive form of vitamin E, in the inhibition of colorectal cancer growth and development in vitro and in vivo. DT3 is the most bioactive isomer of vitamin E in inhibiting growth of colorectal cancer cells.
Kazim Husain, Anying Zhang, Steve Shivers, Ashley Davis-Yadley, Domenico Coppola, Chung S. Yang, Mokenge P. Malafa   +6 more
openaire   +2 more sources