Results 151 to 160 of about 8,111 (184)

Dietary Iron Promotes Azoxymethane-Induced Colon Tumors in Mice

Nutrition and Cancer, 2004
There is accumulating evidence that high levels of dietary iron may play a role in colon carcinogenesis. We used a mouse model to investigate the impact of elevated dietary iron on incidence of aberrant crypt foci (ACF; a preneoplastic lesion) on tumor formation and on induction of oxidative stress. A/J mice were injected intraperitoneally, once a week
Jillian N M, Ilsley, Glenn S, Belinsky, Kishore, Guda, Qi, Zhang, Xi, Huang, Jeffrey B, Blumberg, Paul E, Milbury, L Jackson, Roberts, Richard G, Stevens, Daniel W, Rosenberg   +9 more
openaire   +2 more sources

The effects of dietary selenomethionine on polyamines and azoxymethane-induced aberrant crypts

Cancer Letters, 2000
We evaluated the effects of dietary selenomethionine supplementation on colonic polyamine levels and the ability of L-selenomethionine supplementation to modulate the carcinogenic activity of azoxymethane (AOM) in the rat colon. Four-week-old male F344 rats were treated with 15 mg/kg body weight of AOM once a week for 2 weeks.
A T, Baines, H, Holubec, J L, Basye, P, Thorne, A K, Bhattacharyya, J, Spallholz, B, Shriver, H, Cui, D, Roe, L C, Clark, D L, Earnest, M A, Nelson   +11 more
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Enhancement by thyroxine of experimental carcinogenesis induced in rat colon by azoxymethane

International Journal of Cancer, 1992
AbstractThe effect of thyroxine (T4) on the incidence, number and histology of colon tumors induced by azoxymethane (AOM), and on the labeling index of colon mucosa were investigated in Wistar rats. Rats were given AOM by injection once a week for 10 weeks, together with T4 in depot form until the end of the experiment. Administration of T4 resulted in
H, Iishi, M, Tatsuta, M, Baba, S, Okuda, H, Taniguchi   +4 more
openaire   +2 more sources

Enhancement of azoxymethane‐induced colon carcinogenesis in spontaneously hypertensive rats

International Journal of Cancer, 1990
AbstractThe incidence, number, location, and histological types of colon tumors induced by azoxymethane (AOM) and the tissue norepinephrine concentration of the colon wall were investigated in spontaneously hypertensive (SH) rats and in control normotensive Wistar Kyoto (WKY) rats. All rats received 10 weekly s.c. injections of AOM.
M, Tatsuta, H, Iishi, M, Baba, H, Taniguchi   +3 more
openaire   +2 more sources

Inhibition by putrescine of experimental carcinogenesis in rat colon induced by azoxymethane

International Journal of Cancer, 1991
AbstractThe effects of putrescine on the incidence and number of colon tumors induced by azoxymethane, and on the labelling index and the activity of ornithine decarboxylase (ODC) in the colon mucosa were investigated in Wistar rats. Rats received 10 weekly injections of 7.4 mg/kg body weight of azoxymethane and i.p.
M, Tatsuta, H, Iishi, M, Baba, M, Ichii, A, Nakaizumi, H, Uehara, H, Taniguchi   +6 more
openaire   +2 more sources

The formation of azoxymethane, a colon carcinogen, during the chemical oxidation of methylamine

Carcinogenesis, 1980
Simple chemical oxidation of methylamine in aqueous solution or in methanol leads to the formation of significant amounts of azoxymethane, a strong carcinogen in rodents. Methods, including high pressure liquid chromatography, differential pulse polarography and gas chromatography-mass spectrometry, used for the identification of the carcinogen, are ...
openaire   +2 more sources

Quantitative assessment of azoxymethane-inducedaberrant crypt foci in inbred mice

Experimental and Molecular Pathology, 1999
Heritable differences in tumor susceptibility are observed in mice after repetitive exposures to the organotropic colon carcinogen azoxymethane (AOM). The following study was undertaken to determine whether early morphological alterations within the colonic epithelium correlate with subsequent cancer risk.
D A, Delker, Q S, Wang, A, Papanikolaou, H E, Whiteley, D W, Rosenberg   +4 more
openaire   +2 more sources

Synthesis of vinyloxy-NNO-azoxymethane

Russian Chemical Bulletin, 1998
I. N. Zyuzin, G. N. Nechiporenko
openaire   +1 more source

Effects of timing and quantity of chronic dietary ethanol consumption on azoxymethane-induced colonic carcinogenesis and azoxymethane metabolism in Fischer 344 rats.

Cancer research, 1987
Epidemiological studies have shown an association between consumption of alcoholic beverages and carcinoma of the large bowel, but studies in experimental models of colonic carcinogenesis have yielded conflicting results. We assessed the effects on azoxymethane-induced colonic carcinogenesis of both timing of chronic dietary ethanol consumption ...
S R, Hamilton, O S, Sohn, E S, Fiala
openaire   +1 more source

Determination of micronuclei by azoxymethane in mouse

Toxicology Letters, 2008
Isela Alvarez-Gonzalez, Diana Carvajal, Eduardo Madrigal-Bujaidar   +2 more
openaire   +1 more source