Results 181 to 190 of about 10,720 (219)

Beer Inhibition of Azoxymethane-Induced Colonic Carcinogenesis

2009
Abstract Modulatory effects of beer intake on azoxymethane (AOM)-induced rat colonic carcinogenesis in male Fischer 344 rats were investigated. Single cell gel electrophoresis assay indicated that DNA damage of colonocytes, induced by a single AOM injection (15 mg/kg body weight), was significantly reduced in rats fed beer or malt extract for 2 ...
Hajime Nozawa, Keiji Kondo
openaire   +1 more source

Effect of dietary cholesterol on azoxymethane-induced colon carcinogenesis in rats

Carcinogenesis, 1983
The effect of dietary cholesterol on azoxymethane (AOM)-induced colon carcinogenesis was evaluated with two different sets of experiments. Starting at 6 weeks of age, male Donryu rats were divided into four groups, and fed either control chow or one supplemented with 1% cholesterol, and with or without AOM (11 weekly s.c.
Y, Hiramatsu, H, Takada, M, Yamamura, K, Hioki, K, Saito, M, Yamamoto   +5 more
openaire   +2 more sources

Secondary effects induced by the colon carcinogen azoxymethane in BDIX rats

APMIS, 2004
Azoxymethane (AOM) is claimed to be a colon‐specific carcinogen. In our studies, AOM was administered to adult BDIX/OrlIco rats by four weekly subcutaneous injections of 15 mg/kg body weight each – two periods of 2 weeks of AOM treatment separated by a one‐week break.
Kobaek-Larsen, Morten, Fenger, Claus, Ritskes-Hoitinga, Jelmera   +2 more
openaire   +2 more sources

Enhancement of azoxymethane‐induced colon carcinogenesis in spontaneously hypertensive rats

International Journal of Cancer, 1990
AbstractThe incidence, number, location, and histological types of colon tumors induced by azoxymethane (AOM) and the tissue norepinephrine concentration of the colon wall were investigated in spontaneously hypertensive (SH) rats and in control normotensive Wistar Kyoto (WKY) rats. All rats received 10 weekly s.c. injections of AOM.
M, Tatsuta, H, Iishi, M, Baba, H, Taniguchi   +3 more
openaire   +2 more sources

Enhancement by thyroxine of experimental carcinogenesis induced in rat colon by azoxymethane

International Journal of Cancer, 1992
AbstractThe effect of thyroxine (T4) on the incidence, number and histology of colon tumors induced by azoxymethane (AOM), and on the labeling index of colon mucosa were investigated in Wistar rats. Rats were given AOM by injection once a week for 10 weeks, together with T4 in depot form until the end of the experiment. Administration of T4 resulted in
H, Iishi, M, Tatsuta, M, Baba, S, Okuda, H, Taniguchi   +4 more
openaire   +2 more sources

Metabolism of azoxymethane, methylazoxymethanol and N-nitrosodimethylamine by cytochrome P450IIE1

Carcinogenesis, 1991
The metabolism of azoxymethane (AOM), methylazoxymethanol (MAM) and N-nitrosodimethylamine (NDMA) by liver microsomes from acetone-induced rats as well as by a reconstituted system containing purified cytochrome P450IIE1 was examined. The products consisted of MAM from AOM; methanol and formic acid from MAM; and methylamine, formaldehyde, methanol ...
O S, Sohn, H, Ishizaki, C S, Yang, E S, Fiala   +3 more
openaire   +2 more sources

Age-related changes in biotransformation of azoxymethane and methylazoxymethanolin vitro

Xenobiotica, 1990
1. Age-related changes in hepatic hydroxylation of azoxymethane (AZO) to methylazoxymethanol (MAM), as well as colonic phase I metabolism of MAM by alcohol dehydrogenase (ADH) were examined in young (2-4 months), middle-aged (12-14 months), and old (22-24 months) male Fischer 344 rats.
T F, McMahon, J O, Peggins, M M, Centra, M, Weiner   +3 more
openaire   +2 more sources

Chemoprevention by amiloride of experimental carcinogenesis in rat colon induced by azoxymethane

Carcinogenesis, 1995
The effects of amiloride on the incidence and histology of colon tumors induced by azoxymethane, on the labeling index of the colon mucosa and on the activity of ornithine decarboxylase in the colon wall were investigated in Wistar rats. Rats received 10 weekly injections of 7.4 mg/kg body wt azoxymethane and s.c.
M, Tatsuta, H, Iishi, M, Baba, H, Uehara, A, Nakaizumi   +4 more
openaire   +2 more sources

Dietary Iron Promotes Azoxymethane-Induced Colon Tumors in Mice

Nutrition and Cancer, 2004
There is accumulating evidence that high levels of dietary iron may play a role in colon carcinogenesis. We used a mouse model to investigate the impact of elevated dietary iron on incidence of aberrant crypt foci (ACF; a preneoplastic lesion) on tumor formation and on induction of oxidative stress. A/J mice were injected intraperitoneally, once a week
Jillian N M, Ilsley, Glenn S, Belinsky, Kishore, Guda, Qi, Zhang, Xi, Huang, Jeffrey B, Blumberg, Paul E, Milbury, L Jackson, Roberts, Richard G, Stevens, Daniel W, Rosenberg   +9 more
openaire   +2 more sources

The effects of dietary selenomethionine on polyamines and azoxymethane-induced aberrant crypts

Cancer Letters, 2000
We evaluated the effects of dietary selenomethionine supplementation on colonic polyamine levels and the ability of L-selenomethionine supplementation to modulate the carcinogenic activity of azoxymethane (AOM) in the rat colon. Four-week-old male F344 rats were treated with 15 mg/kg body weight of AOM once a week for 2 weeks.
A T, Baines, H, Holubec, J L, Basye, P, Thorne, A K, Bhattacharyya, J, Spallholz, B, Shriver, H, Cui, D, Roe, L C, Clark, D L, Earnest, M A, Nelson   +11 more
openaire   +2 more sources